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Murcko scaffold

Ring system with 3 rings and 18 atoms

193 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
193
With full pages
6
Scaffold SMILES

c1ccc(N2CCN(c3ccncn3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(N2CCN(c3ccncn3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 193 chemicals

2-Pyrimidinamine, 4-chloro-N-methyl-5-(methylthio)-6-(4-phenyl-1-piperazinyl)- chemical structure, C16H20ClN5S, CAS 55477-25-3
2-Pyrimidinamine, 4-chloro-N-methyl-5-(methylthio)-6-(4-phenyl-1-piperazinyl)-
CAS 55477-25-3C16H20ClN5S
4-Chloro-6-[4-(2,6-dimethylphenyl)piperazino]-2-pyrimidinamine chemical structure, C16H20ClN5, CAS 866018-28-2
4-Chloro-6-[4-(2,6-dimethylphenyl)piperazino]-2-pyrimidinamine
CAS 866018-28-2C16H20ClN5
4-Chloro-6-[4-(2,3-dimethylphenyl)piperazino]-2-pyrimidinamine chemical structure, C16H20ClN5, CAS 339016-04-5
4-Chloro-6-[4-(2,3-dimethylphenyl)piperazino]-2-pyrimidinamine
CAS 339016-04-5C16H20ClN5
4-Chloro-6-[4-(2-ethoxyphenyl)piperazin-1-yl]pyrimidin-2-amine chemical structure, C16H20ClN5O, CAS 339016-17-0
4-Chloro-6-[4-(2-ethoxyphenyl)piperazin-1-yl]pyrimidin-2-amine
CAS 339016-17-0C16H20ClN5O
2-(4-(6-Chloro-2-(methylsulfanyl)-4-pyrimidinyl)tetrahydro-1-pyrazinyl)phenyl ethyl ether chemical structure, C17H21ClN4OS, CAS 339017-68-4
2-(4-(6-Chloro-2-(methylsulfanyl)-4-pyrimidinyl)tetrahydro-1-pyrazinyl)phenyl ethyl ether
CAS 339017-68-4C17H21ClN4OS
4-Chloro-6-(4-(4-fluorophenyl)piperazino)-2-(methylsulfanyl)pyrimidine chemical structure, C15H16ClFN4S, CAS 339017-73-1
4-Chloro-6-(4-(4-fluorophenyl)piperazino)-2-(methylsulfanyl)pyrimidine
CAS 339017-73-1C15H16ClFN4S
4-Chloro-6-(4-(2-chlorophenyl)piperazino)-2-(methylsulfanyl)pyrimidine chemical structure, C15H16Cl2N4S, CAS 339017-77-5
4-Chloro-6-(4-(2-chlorophenyl)piperazino)-2-(methylsulfanyl)pyrimidine
CAS 339017-77-5C15H16Cl2N4S
Ethyl 4-[4-(2-fluorophenyl)piperazino]-2-(methylsulfanyl)-5-pyrimidinecarboxylate chemical structure, C18H21FN4O2S, CAS 339019-52-2
Ethyl 4-[4-(2-fluorophenyl)piperazino]-2-(methylsulfanyl)-5-pyrimidinecarboxylate
CAS 339019-52-2C18H21FN4O2S
2-Chloro-4-[4-(2-chlorophenyl)-1-piperazinyl]pyrimidine chemical structure, C14H14Cl2N4, CAS 444791-65-5
2-Chloro-4-[4-(2-chlorophenyl)-1-piperazinyl]pyrimidine
CAS 444791-65-5C14H14Cl2N4
2-Chloro-4-[4-(4-chlorophenyl)-1-piperazinyl]pyrimidine chemical structure, C14H14Cl2N4, CAS 353259-87-7
2-Chloro-4-[4-(4-chlorophenyl)-1-piperazinyl]pyrimidine
CAS 353259-87-7C14H14Cl2N4
2-Chloro-5-fluoro-4-(4-phenylpiperazin-1-yl)pyrimidine chemical structure, C14H14ClFN4, CAS 355821-33-9
2-Chloro-5-fluoro-4-(4-phenylpiperazin-1-yl)pyrimidine
CAS 355821-33-9C14H14ClFN4
6-[4-(3-Chlorophenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine chemical structure, C14H15ClN6O2, CAS 450345-97-8
6-[4-(3-Chlorophenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine
CAS 450345-97-8C14H15ClN6O2
6-[4-(4-Fluorophenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine chemical structure, C14H15FN6O2, CAS 681271-46-5
6-[4-(4-Fluorophenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine
CAS 681271-46-5C14H15FN6O2
6-[4-(2,5-Dimethylphenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine chemical structure, C16H20N6O2, CAS 450345-98-9
6-[4-(2,5-Dimethylphenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine
CAS 450345-98-9C16H20N6O2
1-(4-(4-(6-Amino-5-nitropyrimidin-4-yl)piperazin-1-yl)phenyl)ethanone chemical structure, C16H18N6O3, CAS 450345-91-2
1-(4-(4-(6-Amino-5-nitropyrimidin-4-yl)piperazin-1-yl)phenyl)ethanone
CAS 450345-91-2C16H18N6O3
6-[4-(4-Methoxyphenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine chemical structure, C15H18N6O3, CAS 450345-90-1
6-[4-(4-Methoxyphenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine
CAS 450345-90-1C15H18N6O3
4-[4-(2-Fluorophenyl)piperazin-1-yl]-N,N-dimethyl-6-(trifluoromethyl)pyrimidin-2-amine chemical structure, C17H19F4N5, CAS 339105-20-3
4-[4-(2-Fluorophenyl)piperazin-1-yl]-N,N-dimethyl-6-(trifluoromethyl)pyrimidin-2-amine
CAS 339105-20-3C17H19F4N5
4-Azido-2-(methylsulfanyl)-6-(4-phenylpiperazino)pyrimidine chemical structure, C15H17N7S, CAS 339017-94-6
4-Azido-2-(methylsulfanyl)-6-(4-phenylpiperazino)pyrimidine
CAS 339017-94-6C15H17N7S
N,N-Dimethyl-4-(4-phenylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-2-amine chemical structure, C17H20F3N5, CAS 339105-48-5
N,N-Dimethyl-4-(4-phenylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-2-amine
CAS 339105-48-5C17H20F3N5
4-[4-(4-Fluorophenyl)piperazin-1-yl]-N,N-dimethyl-6-(trifluoromethyl)pyrimidin-2-amine chemical structure, C17H19F4N5, CAS 339105-15-6
4-[4-(4-Fluorophenyl)piperazin-1-yl]-N,N-dimethyl-6-(trifluoromethyl)pyrimidin-2-amine
CAS 339105-15-6C17H19F4N5
6-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine chemical structure, C14H14Cl2N6O2, CAS 497063-43-1
6-[4-(3,4-Dichlorophenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine
CAS 497063-43-1C14H14Cl2N6O2
N,N-Dimethyl-4-(trifluoromethyl)-6-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-pyrimidinamine chemical structure, C18H19F6N5, CAS 339105-22-5
N,N-Dimethyl-4-(trifluoromethyl)-6-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-pyrimidinamine
CAS 339105-22-5C18H19F6N5
6-[4-(2-Chlorophenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine chemical structure, C14H15ClN6O2, CAS 450345-88-7
6-[4-(2-Chlorophenyl)piperazin-1-yl]-5-nitropyrimidin-4-amine
CAS 450345-88-7C14H15ClN6O2
5-Nitro-6-[4-(4-nitrophenyl)piperazin-1-yl]pyrimidin-4-amine chemical structure, C14H15N7O4, CAS 497063-42-0
5-Nitro-6-[4-(4-nitrophenyl)piperazin-1-yl]pyrimidin-4-amine
CAS 497063-42-0C14H15N7O4