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Murcko scaffold

1,4-Diphenylpiperazine scaffold

208 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
208
With full pages
26
Scaffold SMILES

c1ccc(N2CCN(c3ccccc3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Diphenylpiperazine page
Murcko scaffold c1ccc(N2CCN(c3ccccc3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 208 chemicals

1,4-Diphenylpiperazine chemical structure, C16H18N2, CAS 613-39-8
1,4-Diphenylpiperazine
CAS 613-39-8C16H18N2
1,4-Bis(4-nitrosophenyl)piperazine chemical structure, C16H16N4O2, CAS 4963-30-8
1,4-Bis(4-nitrosophenyl)piperazine
CAS 4963-30-8C16H16N4O2
1,4-Diphenylpiperazine--hydrogen chloride (1/1) chemical structure, C16H19ClN2, CAS 13548-82-8
1,4-Diphenylpiperazine--hydrogen chloride (1/1)
CAS 13548-82-8C16H19ClN2
1,4-Bis(4-nitrophenyl)piperazine chemical structure, C16H16N4O4, CAS 16264-05-4
1,4-Bis(4-nitrophenyl)piperazine
CAS 16264-05-4C16H16N4O4
1,4-Bis(2,4-dinitrophenyl)piperazine chemical structure, C16H14N6O8, CAS 7061-92-9
1,4-Bis(2,4-dinitrophenyl)piperazine
CAS 7061-92-9C16H14N6O8
Benzenamine, 4-(4-(4-methoxyphenyl)-1-piperazinyl)- chemical structure, C17H21N3O, CAS 74852-62-3
Benzenamine, 4-(4-(4-methoxyphenyl)-1-piperazinyl)-
CAS 74852-62-3C17H21N3O
2,6-Bis(bromomethyl)-1,4-diphenylpiperazine chemical structure, C18H20Br2N2, CAS 30788-18-2
2,6-Bis(bromomethyl)-1,4-diphenylpiperazine
CAS 30788-18-2C18H20Br2N2
1-(2,4-Dinitrophenyl)-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C17H15F3N4O4, CAS 78070-19-6
1-(2,4-Dinitrophenyl)-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 78070-19-6C17H15F3N4O4
1,4-Bis(4-chlorophenyl)piperazine chemical structure, C16H16Cl2N2, CAS 3367-54-2
1,4-Bis(4-chlorophenyl)piperazine
CAS 3367-54-2C16H16Cl2N2
1,4-Bis(4-methylphenyl)piperazine chemical structure, C18H22N2, CAS 3367-48-4
1,4-Bis(4-methylphenyl)piperazine
CAS 3367-48-4C18H22N2
4,4'-(Piperazine-1,4-diyl)dianiline chemical structure, C16H20N4, CAS 7479-12-1
4,4'-(Piperazine-1,4-diyl)dianiline
CAS 7479-12-1C16H20N4
4-[4-(4-Carbamimidoylphenyl)piperazin-1-yl]benzenecarboximidamide chemical structure, C18H22N6, CAS 123885-92-7
4-[4-(4-Carbamimidoylphenyl)piperazin-1-yl]benzenecarboximidamide
CAS 123885-92-7C18H22N6
4-[4-(4-Cyanophenyl)piperazin-1-yl]benzonitrile chemical structure, C18H16N4, CAS 101722-12-7
4-[4-(4-Cyanophenyl)piperazin-1-yl]benzonitrile
CAS 101722-12-7C18H16N4
N-{4-[4-(4-Methoxyphenyl)-1-piperazinyl]phenyl}hydrazinecarboxamide chemical structure, C18H23N5O2, CAS 74852-89-4
N-{4-[4-(4-Methoxyphenyl)-1-piperazinyl]phenyl}hydrazinecarboxamide
CAS 74852-89-4C18H23N5O2
2-[4-(4-Fluorophenyl)piperazin-1-yl]aniline chemical structure, C16H18FN3, CAS 603117-42-6
2-[4-(4-Fluorophenyl)piperazin-1-yl]aniline
CAS 603117-42-6C16H18FN3
N-[2-(4-Phenylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]acetamide chemical structure, C19H20F3N3O, CAS 695199-02-1
N-[2-(4-Phenylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]acetamide
CAS 695199-02-1C19H20F3N3O
4-[4-(4-Fluorophenyl)piperazino]aniline chemical structure, C16H18FN3, CAS 251097-69-5
4-[4-(4-Fluorophenyl)piperazino]aniline
CAS 251097-69-5C16H18FN3
3-Fluoro-4-(4-phenylpiperazin-1-yl)aniline chemical structure, C16H18FN3, CAS 478079-57-1
3-Fluoro-4-(4-phenylpiperazin-1-yl)aniline
CAS 478079-57-1C16H18FN3
Methyl 3-amino-4-(4-phenylpiperazin-1-yl)benzoate chemical structure, C18H21N3O2, CAS 65639-65-8
Methyl 3-amino-4-(4-phenylpiperazin-1-yl)benzoate
CAS 65639-65-8C18H21N3O2
4-[4-(3,4-Dichlorophenyl)piperazin-1-yl]aniline chemical structure, C16H17Cl2N3, CAS 794552-08-2
4-[4-(3,4-Dichlorophenyl)piperazin-1-yl]aniline
CAS 794552-08-2C16H17Cl2N3
1,4-Bis[2-nitro-4-(trifluoromethyl)phenyl]piperazine chemical structure, C18H14F6N4O4, CAS 137918-81-1
1,4-Bis[2-nitro-4-(trifluoromethyl)phenyl]piperazine
CAS 137918-81-1C18H14F6N4O4
1-(4-Fluorophenyl)-4-(4-nitrophenyl)piperazine chemical structure, C16H16FN3O2, CAS 251097-68-4
1-(4-Fluorophenyl)-4-(4-nitrophenyl)piperazine
CAS 251097-68-4C16H16FN3O2
N-{4-[4-(4-Fluorophenyl)piperazino]phenyl}acetamide chemical structure, C18H20FN3O, CAS 303151-18-0
N-{4-[4-(4-Fluorophenyl)piperazino]phenyl}acetamide
CAS 303151-18-0C18H20FN3O
N-{4-[4-(4-Fluorophenyl)piperazino]phenyl}pentanamide chemical structure, C21H26FN3O, CAS 303151-20-4
N-{4-[4-(4-Fluorophenyl)piperazino]phenyl}pentanamide
CAS 303151-20-4C21H26FN3O