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Murcko scaffold

1-Phenyl-4-(pyridin-2-yl)piperazine scaffold

244 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
244
With full pages
32
Scaffold SMILES

c1ccc(N2CCN(c3ccccn3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-4-(pyridin-2-yl)piperazine page
Murcko scaffold c1ccc(N2CCN(c3ccccn3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 244 chemicals

2-(4-Phenylpiperazin-1-yl)pyridin-3-amine chemical structure, C15H18N4, CAS 14549-64-5
2-(4-Phenylpiperazin-1-yl)pyridin-3-amine
CAS 14549-64-5C15H18N4
Piperazine, 1-(3-amino-2-pyridyl)-4-(4-methoxyphenyl)- chemical structure, C16H20N4O, CAS 16019-78-6
Piperazine, 1-(3-amino-2-pyridyl)-4-(4-methoxyphenyl)-
CAS 16019-78-6C16H20N4O
Piperazine, 1-(3-amino-2-pyridyl)-4-(p-tolyl)- chemical structure, C16H20N4, CAS 16019-80-0
Piperazine, 1-(3-amino-2-pyridyl)-4-(p-tolyl)-
CAS 16019-80-0C16H20N4
4-(Methoxymethyl)-6-methyl-2-(4-phenyl-1-piperazinyl)-3-pyridinecarbonitrile chemical structure, C19H22N4O, CAS 371225-21-7
4-(Methoxymethyl)-6-methyl-2-(4-phenyl-1-piperazinyl)-3-pyridinecarbonitrile
CAS 371225-21-7C19H22N4O
2-(4-Phenylpiperazin-1-yl)pyridine-3-carboxamide chemical structure, C16H18N4O, CAS 101512-13-4
2-(4-Phenylpiperazin-1-yl)pyridine-3-carboxamide
CAS 101512-13-4C16H18N4O
1-[4-[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]phenyl]ethanone chemical structure, C18H18F3N3O, CAS 420844-60-6
1-[4-[4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl]phenyl]ethanone
CAS 420844-60-6C18H18F3N3O
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-4,6-dimethylpyridine-3-carbonitrile chemical structure, C19H22N4O, CAS 842113-02-4
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-4,6-dimethylpyridine-3-carbonitrile
CAS 842113-02-4C19H22N4O
2-[4-(2-Fluorophenyl)piperazin-1-yl]-4,6-dimethylpyridine-3-carbonitrile chemical structure, C18H19FN4, CAS 842113-20-6
2-[4-(2-Fluorophenyl)piperazin-1-yl]-4,6-dimethylpyridine-3-carbonitrile
CAS 842113-20-6C18H19FN4
2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-4,6-dimethylpyridine-3-carbonitrile chemical structure, C20H24N4, CAS 842954-69-2
2-[4-(2,3-Dimethylphenyl)piperazin-1-yl]-4,6-dimethylpyridine-3-carbonitrile
CAS 842954-69-2C20H24N4
4-Methoxy-2-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile chemical structure, C17H18N4O, CAS 338773-33-4
4-Methoxy-2-(4-phenylpiperazin-1-yl)pyridine-3-carbonitrile
CAS 338773-33-4C17H18N4O
1-(4-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}phenyl)-3-(dimethylamino)-2-propen-1-one chemical structure, C21H22ClF3N4O, CAS 1164529-81-0
1-(4-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}phenyl)-3-(dimethylamino)-2-propen-1-one
CAS 1164529-81-0C21H22ClF3N4O
Propan-2-yl 2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyridine-3-carboxylate chemical structure, C20H22F3N3O2, CAS 400086-51-3
Propan-2-yl 2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]pyridine-3-carboxylate
CAS 400086-51-3C20H22F3N3O2
Methyl 2-(4-phenylpiperazin-1-yl)pyridine-3-carboxylate chemical structure, C17H19N3O2, CAS 400086-57-9
Methyl 2-(4-phenylpiperazin-1-yl)pyridine-3-carboxylate
CAS 400086-57-9C17H19N3O2
Methyl 2-[4-(3-chlorophenyl)piperazin-1-yl]pyridine-3-carboxylate chemical structure, C17H18ClN3O2, CAS 400086-58-0
Methyl 2-[4-(3-chlorophenyl)piperazin-1-yl]pyridine-3-carboxylate
CAS 400086-58-0C17H18ClN3O2
Methyl 2-[4-(2-chlorophenyl)piperazin-1-yl]pyridine-3-carboxylate chemical structure, C17H18ClN3O2, CAS 339011-23-3
Methyl 2-[4-(2-chlorophenyl)piperazin-1-yl]pyridine-3-carboxylate
CAS 339011-23-3C17H18ClN3O2
Propan-2-yl 6-(4-phenylpiperazin-1-yl)pyridine-3-carboxylate chemical structure, C19H23N3O2, CAS 400086-59-1
Propan-2-yl 6-(4-phenylpiperazin-1-yl)pyridine-3-carboxylate
CAS 400086-59-1C19H23N3O2
Propan-2-yl 6-[4-(4-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate chemical structure, C19H22FN3O2, CAS 400086-60-4
Propan-2-yl 6-[4-(4-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate
CAS 400086-60-4C19H22FN3O2
Propan-2-yl 6-[4-(2-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate chemical structure, C19H22FN3O2, CAS 400086-61-5
Propan-2-yl 6-[4-(2-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate
CAS 400086-61-5C19H22FN3O2
Propan-2-yl 6-[4-(3-chlorophenyl)piperazin-1-yl]pyridine-3-carboxylate chemical structure, C19H22ClN3O2, CAS 339011-26-6
Propan-2-yl 6-[4-(3-chlorophenyl)piperazin-1-yl]pyridine-3-carboxylate
CAS 339011-26-6C19H22ClN3O2
2,2,2-Trifluoroethyl 6-[4-(2-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate chemical structure, C18H17F4N3O2, CAS 400086-62-6
2,2,2-Trifluoroethyl 6-[4-(2-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate
CAS 400086-62-6C18H17F4N3O2
2,2,2-Trifluoroethyl 6-[4-(4-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate chemical structure, C18H17F4N3O2, CAS 400086-63-7
2,2,2-Trifluoroethyl 6-[4-(4-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate
CAS 400086-63-7C18H17F4N3O2
2,2,2-Trifluoroethyl 6-[4-(3-chlorophenyl)piperazino]nicotinate chemical structure, C18H17ClF3N3O2, CAS 339011-29-9
2,2,2-Trifluoroethyl 6-[4-(3-chlorophenyl)piperazino]nicotinate
CAS 339011-29-9C18H17ClF3N3O2
Methyl 6-(4-phenylpiperazin-1-yl)pyridine-3-carboxylate chemical structure, C17H19N3O2, CAS 132521-73-4
Methyl 6-(4-phenylpiperazin-1-yl)pyridine-3-carboxylate
CAS 132521-73-4C17H19N3O2
Methyl 6-[4-(2-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate chemical structure, C17H18FN3O2, CAS 339011-33-5
Methyl 6-[4-(2-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate
CAS 339011-33-5C17H18FN3O2