Murcko scaffold
Ring system with 4 rings and 25 atoms
23 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 25
- Chemicals
- 23
- With full pages
- 2
Scaffold SMILES
O=c1c(N=Nc2ccccc2)c[nH]n1-c1nc(-c2ccccc2)cs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1c(N=Nc2ccccc2)c[nH]n1-c1nc(-c2ccccc2)cs1](/scaffold/UVZPXRGQDVFETF-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 23 of 23 chemicals
![4-[(2-Methoxy-phenyl)-hydrazono]-5-methyl-2-(4-phenyl-thiazol-2-yl)-2,4-dihydro- chemical structure, C20H17N5O2S, CAS 325826-64-0](/s/RPIVJQKJKMKHIK-UHFFFAOYSA-N.svg)
4-[(2-Methoxy-phenyl)-hydrazono]-5-methyl-2-(4-phenyl-thiazol-2-yl)-2,4-dihydro-
CAS 325826-64-0C20H17N5O2S
![3-{2-[3-Methyl-5-oxo-1-(4-phenyl-1,3-thiazol-2-yl)-1,5-dihydro-4H-pyrazol-4-yliden]hydrazino}benzoic acid chemical structure, C20H15N5O3S, CAS 314292-44-9](/s/AEFUZVUARSRYAX-UHFFFAOYSA-N.svg)
3-{2-[3-Methyl-5-oxo-1-(4-phenyl-1,3-thiazol-2-yl)-1,5-dihydro-4H-pyrazol-4-yliden]hydrazino}benzoic acid
CAS 314292-44-9C20H15N5O3S
(E)-4-(2-(2,4-Dimethylphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one
CAS 314291-98-0C21H19N5OS
(E)-4-(2-(3-Chlorophenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one
CAS 314290-18-1C19H14ClN5OS
![4-(2-{1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid chemical structure, C20H14ClN5O3S, CAS 314761-55-2](/s/VOSGOQSPLRDHAY-UHFFFAOYSA-N.svg)
4-(2-{1-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid
CAS 314761-55-2C20H14ClN5O3S
![(4Z)-4-[(2-Methoxy-5-nitrophenyl)hydrazinylidene]-5-methyl-2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]pyrazol-3-one chemical structure, C20H15N7O6S, CAS 314759-12-1](/s/INBXLABUKXNZNK-UHFFFAOYSA-N.svg)
(4Z)-4-[(2-Methoxy-5-nitrophenyl)hydrazinylidene]-5-methyl-2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]pyrazol-3-one
CAS 314759-12-1C20H15N7O6S
(E)-4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one
CAS 331244-89-4C21H19N5O2S
![(4E)-5-Methyl-2-(4-phenyl-1,3-thiazol-2-yl)-4-{2-[2-(trifluoromethyl)phenyl]hydrazinylidene}-2,4-dihydro-3H-pyrazol-3-one chemical structure, C20H14F3N5OS, CAS 314292-99-4](/s/MKWAGPXSYMIOHB-UHFFFAOYSA-N.svg)
(4E)-5-Methyl-2-(4-phenyl-1,3-thiazol-2-yl)-4-{2-[2-(trifluoromethyl)phenyl]hydrazinylidene}-2,4-dihydro-3H-pyrazol-3-one
CAS 314292-99-4C20H14F3N5OS
![3-((2E)-2-{1-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid chemical structure, C21H17N5O4S, CAS 1482516-64-2](/s/VUPPFJGPYUVFJY-UHFFFAOYSA-N.svg)
3-((2E)-2-{1-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid
CAS 1482516-64-2C21H17N5O4S
![2-{(2Z)-2-[3-Methyl-5-oxo-1-(4-phenyl-1,3-thiazol-2-yl)-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazinyl}benzoic acid chemical structure, C20H15N5O3S, CAS 314292-25-6](/s/SPNNJAZVRAMMBG-UHFFFAOYSA-N.svg)
2-{(2Z)-2-[3-Methyl-5-oxo-1-(4-phenyl-1,3-thiazol-2-yl)-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazinyl}benzoic acid
CAS 314292-25-6C20H15N5O3S
![4-(2-{1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid chemical structure, C20H14BrN5O3S, CAS 314290-87-4](/s/XYBUBQKUSFLGRN-UHFFFAOYSA-N.svg)
4-(2-{1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid
CAS 314290-87-4C20H14BrN5O3S
![4-[(3-Bromophenyl)hydrazono]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one chemical structure, C19H14BrN5OS, CAS 314766-10-4](/s/CQCUCCDZHIKFMQ-UHFFFAOYSA-N.svg)
4-[(3-Bromophenyl)hydrazono]-5-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one
CAS 314766-10-4C19H14BrN5OS
![4-(2-{3-Methyl-1-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid chemical structure, C20H14N6O5S, CAS 314291-30-0](/s/MIWXBDNOEBMEHE-UHFFFAOYSA-N.svg)
4-(2-{3-Methyl-1-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid
CAS 314291-30-0C20H14N6O5S
![(4E)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-4-[2-(2-methoxyphenyl)hydrazinylidene]-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C20H16ClN5O2S, CAS 327042-07-9](/s/XQFZNTLOBBJKIF-UHFFFAOYSA-N.svg)
(4E)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-4-[2-(2-methoxyphenyl)hydrazinylidene]-5-methyl-2,4-dihydro-3H-pyrazol-3-one
CAS 327042-07-9C20H16ClN5O2S
![2-(2-{1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid chemical structure, C20H14BrN5O3S, CAS 314292-20-1](/s/DMGNDHPZYYYXQS-UHFFFAOYSA-N.svg)
2-(2-{1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid
CAS 314292-20-1C20H14BrN5O3S
![2-((2E)-2-{1-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid chemical structure, C21H17N5O4S, CAS 314290-54-5](/s/SGAZBRPORQVQCS-UHFFFAOYSA-N.svg)
2-((2E)-2-{1-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid
CAS 314290-54-5C21H17N5O4S
(E)-Ethyl 4-(2-(3-methyl-5-oxo-1-(4-phenylthiazol-2-yl)-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzoate
CAS 314291-08-2C22H19N5O3S
![(4Z)-5-Methyl-4-[2-(3-nitrophenyl)hydrazinylidene]-2-(4-phenyl-1,3-thiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one chemical structure, C19H14N6O3S, CAS 314291-84-4](/s/CZVLBUWWFKVXHA-UHFFFAOYSA-N.svg)
(4Z)-5-Methyl-4-[2-(3-nitrophenyl)hydrazinylidene]-2-(4-phenyl-1,3-thiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one
CAS 314291-84-4C19H14N6O3S
![(4E)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-4-[2-(4-hydroxyphenyl)hydrazinylidene]-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C19H14ClN5O2S, CAS 5725-68-8](/s/WLLNUCDAXGASML-UHFFFAOYSA-N.svg)
(4E)-2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-4-[2-(4-hydroxyphenyl)hydrazinylidene]-5-methyl-2,4-dihydro-3H-pyrazol-3-one
CAS 5725-68-8C19H14ClN5O2S
![2-Hydroxy-4-[(2Z)-2-{1-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazinyl]benzoic acid chemical structure, C21H17N5O5S, CAS 314759-58-5](/s/LJGGMAJGYYQSCL-UHFFFAOYSA-N.svg)
2-Hydroxy-4-[(2Z)-2-{1-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazinyl]benzoic acid
CAS 314759-58-5C21H17N5O5S
![2-(2-{3-Methyl-1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid chemical structure, C21H17N5O3S, CAS 314290-19-2](/s/YVSRSTOQFDIWSF-UHFFFAOYSA-N.svg)
2-(2-{3-Methyl-1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene}hydrazino)benzoic acid
CAS 314290-19-2C21H17N5O3S
![(4E)-4-[2-(2,4-Dichlorophenyl)hydrazinylidene]-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-5-methyl-2,4-dihydro-3H-pyrazol-3-one chemical structure, C20H15Cl2N5O2S, CAS 5592-81-4](/s/PTHUKOOYZUNQNU-UHFFFAOYSA-N.svg)
(4E)-4-[2-(2,4-Dichlorophenyl)hydrazinylidene]-2-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-5-methyl-2,4-dihydro-3H-pyrazol-3-one
CAS 5592-81-4C20H15Cl2N5O2S
![(4Z)-4-[2-(2-Hydroxyphenyl)hydrazinylidene]-5-methyl-2-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-2,4-dihydro-3H-pyrazol-3-one chemical structure, C20H17N5O2S, CAS 5589-60-6](/s/DVCGMXSSUXGHPK-UHFFFAOYSA-N.svg)
(4Z)-4-[2-(2-Hydroxyphenyl)hydrazinylidene]-5-methyl-2-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-2,4-dihydro-3H-pyrazol-3-one
CAS 5589-60-6C20H17N5O2S
Related scaffolds
Same ring framework with different atoms or bond orders
