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Murcko scaffold

1-Phenyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione scaffold

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
10
With full pages
3
Scaffold SMILES

O=C1CCCC2=C1CC(=O)N2c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione page
Murcko scaffold O=C1CCCC2=C1CC(=O)N2c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

1-(4-Fluorophenyl)-3-hydroxy-6,6-dimethyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione chemical structure, C17H15F4NO3, CAS 586996-26-1
1-(4-Fluorophenyl)-3-hydroxy-6,6-dimethyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione
CAS 586996-26-1C17H15F4NO3
N-[1-(4-Methoxyphenyl)-6,6-dimethyl-2,4-dioxo-3-(trifluoromethyl)-5,7-dihydroindol-3-yl]-2,2-dimethylpropanamide chemical structure, C23H27F3N2O4, CAS 664370-46-1
N-[1-(4-Methoxyphenyl)-6,6-dimethyl-2,4-dioxo-3-(trifluoromethyl)-5,7-dihydroindol-3-yl]-2,2-dimethylpropanamide
CAS 664370-46-1C23H27F3N2O4
1-(3,4-Dimethylphenyl)-3-hydroxy-6,6-dimethyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione chemical structure, C19H20F3NO3, CAS 577962-97-1
1-(3,4-Dimethylphenyl)-3-hydroxy-6,6-dimethyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione
CAS 577962-97-1C19H20F3NO3
N-[1-(3,4-Dimethylphenyl)-6,6-dimethyl-2,4-dioxo-3-(trifluoromethyl)-5,7-dihydroindol-3-yl]-2,2-dimethylpropanamide chemical structure, C24H29F3N2O3, CAS 606924-69-0
N-[1-(3,4-Dimethylphenyl)-6,6-dimethyl-2,4-dioxo-3-(trifluoromethyl)-5,7-dihydroindol-3-yl]-2,2-dimethylpropanamide
CAS 606924-69-0C24H29F3N2O3
3-Hydroxy-6,6-dimethyl-1-(4-methylphenyl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione chemical structure, C18H18F3NO3, CAS 577788-77-3
3-Hydroxy-6,6-dimethyl-1-(4-methylphenyl)-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione
CAS 577788-77-3C18H18F3NO3
N-[6,6-Dimethyl-1-(4-methylphenyl)-2,4-dioxo-3-(trifluoromethyl)-5,7-dihydroindol-3-yl]-2,2-dimethylpropanamide chemical structure, C23H27F3N2O3, CAS 578734-30-2
N-[6,6-Dimethyl-1-(4-methylphenyl)-2,4-dioxo-3-(trifluoromethyl)-5,7-dihydroindol-3-yl]-2,2-dimethylpropanamide
CAS 578734-30-2C23H27F3N2O3
N-[1-(3,4-Dichlorophenyl)-6,6-dimethyl-2,4-dioxo-3-(trifluoromethyl)-5,7-dihydroindol-3-yl]-2,2-dimethylpropanamide chemical structure, C22H23Cl2F3N2O3, CAS 606924-79-2
N-[1-(3,4-Dichlorophenyl)-6,6-dimethyl-2,4-dioxo-3-(trifluoromethyl)-5,7-dihydroindol-3-yl]-2,2-dimethylpropanamide
CAS 606924-79-2C22H23Cl2F3N2O3
N-[6,6-Dimethyl-2,4-dioxo-3-(trifluoromethyl)-1-[3-(trifluoromethyl)phenyl]-5,7-dihydroindol-3-yl]-2,2-dimethylpropanamide chemical structure, C23H24F6N2O3, CAS 587011-88-9
N-[6,6-Dimethyl-2,4-dioxo-3-(trifluoromethyl)-1-[3-(trifluoromethyl)phenyl]-5,7-dihydroindol-3-yl]-2,2-dimethylpropanamide
CAS 587011-88-9C23H24F6N2O3
1-Phenyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione chemical structure, C14H13NO2, CAS 113604-66-3
1-Phenyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione
CAS 113604-66-3C14H13NO2
6,6-Dimethyl-1-phenyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione chemical structure, C16H17NO2, CAS 113604-75-4
6,6-Dimethyl-1-phenyl-3,5,6,7-tetrahydro-1H-indole-2,4-dione
CAS 113604-75-4C16H17NO2