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Murcko scaffold

1,4,5,6-Tetrahydropyrimidine scaffold

195 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
6
Chemicals
195
With full pages
23
Scaffold SMILES

C1=NCCCN1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.

Substructure search with this scaffoldOpen the 1,4,5,6-Tetrahydropyrimidine page
Murcko scaffold C1=NCCCN1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 195 chemicals

2-Methyl-4-carboxy-3,4,5,6-tetrahydropyrimidine chemical structure, C6H10N2O2, CAS 117305-84-7
2-Methyl-4-carboxy-3,4,5,6-tetrahydropyrimidine
CAS 117305-84-7C6H10N2O2
Prop-2-yn-1-yl 1,4,5,6-tetrahydropyrimidine-5-carboxylate chemical structure, C8H10N2O2, CAS 185444-95-5
Prop-2-yn-1-yl 1,4,5,6-tetrahydropyrimidine-5-carboxylate
CAS 185444-95-5C8H10N2O2
1,4,5,6-Tetrahydro-1,2,4-trimethylpyrimidine chemical structure, C7H14N2, CAS 53517-92-3
1,4,5,6-Tetrahydro-1,2,4-trimethylpyrimidine
CAS 53517-92-3C7H14N2
Pyrimidine, 1,4,5,6-tetrahydro-1,2-dimethyl- chemical structure, C6H12N2, CAS 4271-96-9
Pyrimidine, 1,4,5,6-tetrahydro-1,2-dimethyl-
CAS 4271-96-9C6H12N2
Ectoine chemical structure, C6H10N2O2, CAS 96702-03-3
Ectoine
CAS 96702-03-3C6H10N2O2
1,4,5,6-Tetrahydropyrimidine chemical structure, C4H8N2, CAS 1606-49-1
1,4,5,6-Tetrahydropyrimidine
CAS 1606-49-1C4H8N2
4-Pyrimidinepropanoic acid, alpha,2-diamino-1,4,5,6-tetrahydro- chemical structure, C7H14N4O2, CAS 72748-96-0
4-Pyrimidinepropanoic acid, alpha,2-diamino-1,4,5,6-tetrahydro-
CAS 72748-96-0C7H14N4O2
1-Carboxymethyl-2-iminohexahydropyrimidine chemical structure, C6H11N3O2, CAS 35404-56-9
1-Carboxymethyl-2-iminohexahydropyrimidine
CAS 35404-56-9C6H11N3O2
Pyrimidine, 1,4,5,6-tetrahydro-2-(methylthio)-, hydriodide (1:1) chemical structure, C5H11IN2S, CAS 5445-73-8
Pyrimidine, 1,4,5,6-tetrahydro-2-(methylthio)-, hydriodide (1:1)
CAS 5445-73-8C5H11IN2S
2-(Methylsulfanyl)-1,4,5,6-tetrahydropyrimidine chemical structure, C5H10N2S, CAS 20112-81-6
2-(Methylsulfanyl)-1,4,5,6-tetrahydropyrimidine
CAS 20112-81-6C5H10N2S
2-Imino-1,3-diazinane-4-carboxylic acid chemical structure, C5H9N3O2, CAS 738558-38-8
2-Imino-1,3-diazinane-4-carboxylic acid
CAS 738558-38-8C5H9N3O2
Methyl 2-imino-1,3-diazinane-4-carboxylate--hydrogen chloride (1/1) chemical structure, C6H12ClN3O2, CAS 28958-95-4
Methyl 2-imino-1,3-diazinane-4-carboxylate--hydrogen chloride (1/1)
CAS 28958-95-4C6H12ClN3O2
Methyl 2-amino-1,4,5,6-tetrahydropyrimidine-6-carboxylate chemical structure, C6H11N3O2, CAS 158832-50-9
Methyl 2-amino-1,4,5,6-tetrahydropyrimidine-6-carboxylate
CAS 158832-50-9C6H11N3O2
4-Pyrimidinol, 3,4,5,6-tetrahydro-2-methylthio-3,4,6,6-tetramethyl-, hydriodide chemical structure, C9H19IN2OS, CAS 34928-02-4
4-Pyrimidinol, 3,4,5,6-tetrahydro-2-methylthio-3,4,6,6-tetramethyl-, hydriodide
CAS 34928-02-4C9H19IN2OS
4-Pyrimidinol, 3,4,5,6-tetrahydro-2-ethylthio-4,6,6-trimethyl-, hdrobromide chemical structure, C9H19BrN2OS, CAS 34928-03-5
4-Pyrimidinol, 3,4,5,6-tetrahydro-2-ethylthio-4,6,6-trimethyl-, hdrobromide
CAS 34928-03-5C9H19BrN2OS
Pyrimidine, 1-butyl-1,4,5,6-tetrahydro-2-undecyl- chemical structure, C19H38N2, CAS 5327-73-1
Pyrimidine, 1-butyl-1,4,5,6-tetrahydro-2-undecyl-
CAS 5327-73-1C19H38N2
1(4H)-Pyrimidineethanol,6-dihydro- chemical structure, C23H46N2O, CAS 69470-39-9
1(4H)-Pyrimidineethanol,6-dihydro-
CAS 69470-39-9C23H46N2O
2-Heptadecyl-1,4,5,6-tetrahydropyrimidine chemical structure, C21H42N2, CAS 88097-26-1
2-Heptadecyl-1,4,5,6-tetrahydropyrimidine
CAS 88097-26-1C21H42N2
2-Butan-2-yl-1,4,5,6-tetrahydropyrimidine chemical structure, C8H16N2, CAS 80676-54-6
2-Butan-2-yl-1,4,5,6-tetrahydropyrimidine
CAS 80676-54-6C8H16N2
N,N-Dimethyl-1,4,5,6-tetrahydropyrimidin-2-amine chemical structure, C6H13N3, CAS 35394-41-3
N,N-Dimethyl-1,4,5,6-tetrahydropyrimidin-2-amine
CAS 35394-41-3C6H13N3
2-Amino-1,4,5,6-tetrahydropyrimidin-5-ol chemical structure, C4H9N3O, CAS 19622-93-6
2-Amino-1,4,5,6-tetrahydropyrimidin-5-ol
CAS 19622-93-6C4H9N3O
N-(1,4,5,6-Tetrahydropyrimidin-2-yl)nitramide chemical structure, C4H8N4O2, CAS 53360-90-0
N-(1,4,5,6-Tetrahydropyrimidin-2-yl)nitramide
CAS 53360-90-0C4H8N4O2
2-(Chloromethyl)-1,4,5,6-tetrahydropyrimidine chemical structure, C5H9ClN2, CAS 40403-76-7
2-(Chloromethyl)-1,4,5,6-tetrahydropyrimidine
CAS 40403-76-7C5H9ClN2
3-(1,4,5,6-Tetrahydro-pyrimidin-2-ylsulfanyl)-propylamine chemical structure, C7H15N3S, CAS 7391-14-2
3-(1,4,5,6-Tetrahydro-pyrimidin-2-ylsulfanyl)-propylamine
CAS 7391-14-2C7H15N3S