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Murcko scaffold

Ring system with 2 rings and 18 atoms

12 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
18
Chemicals
12
With full pages
3
Scaffold SMILES

O=C(C=Cc1ccccc1)NCc1cccnc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)NCc1cccnc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

3-(3-Nitro-phenyl)-N-pyridin-3-ylmethyl-acrylamide chemical structure, C15H13N3O3, CAS 1164554-83-9
3-(3-Nitro-phenyl)-N-pyridin-3-ylmethyl-acrylamide
CAS 1164554-83-9C15H13N3O3
3-(2-Chlorophenyl)-N-(3-pyridinylmethyl)acrylamide chemical structure, C15H13ClN2O, CAS 1287721-11-2
3-(2-Chlorophenyl)-N-(3-pyridinylmethyl)acrylamide
CAS 1287721-11-2C15H13ClN2O
2-Cyano-3-(3,4-dichlorophenyl)-N-(3-pyridinylmethyl)-2-propenamide chemical structure, C16H11Cl2N3O, CAS 333345-63-4
2-Cyano-3-(3,4-dichlorophenyl)-N-(3-pyridinylmethyl)-2-propenamide
CAS 333345-63-4C16H11Cl2N3O
(E)-3-(2-Chloro-6-fluorophenyl)-2-cyano-N-(pyridin-3-ylmethyl)prop-2-enamide chemical structure, C16H11ClFN3O, CAS 333345-67-8
(E)-3-(2-Chloro-6-fluorophenyl)-2-cyano-N-(pyridin-3-ylmethyl)prop-2-enamide
CAS 333345-67-8C16H11ClFN3O
3-(4-tert-Butylphenyl)-2-cyano-N-[(pyridin-3-yl)methyl]prop-2-enamide chemical structure, C20H21N3O, CAS 333346-03-5
3-(4-tert-Butylphenyl)-2-cyano-N-[(pyridin-3-yl)methyl]prop-2-enamide
CAS 333346-03-5C20H21N3O
(E)-3-(4-Propan-2-ylphenyl)-N-(pyridin-3-ylmethyl)prop-2-enamide chemical structure, C18H20N2O, CAS 330441-11-7
(E)-3-(4-Propan-2-ylphenyl)-N-(pyridin-3-ylmethyl)prop-2-enamide
CAS 330441-11-7C18H20N2O
(E)-3-(4-Chloro-3-nitrophenyl)-N-(pyridin-3-ylmethyl)prop-2-enamide chemical structure, C15H12ClN3O3, CAS 433258-31-2
(E)-3-(4-Chloro-3-nitrophenyl)-N-(pyridin-3-ylmethyl)prop-2-enamide
CAS 433258-31-2C15H12ClN3O3
(E)-3-(2,6-Dichlorophenyl)-N-(pyridin-3-ylmethyl)prop-2-enamide chemical structure, C15H12Cl2N2O, CAS 545364-85-0
(E)-3-(2,6-Dichlorophenyl)-N-(pyridin-3-ylmethyl)prop-2-enamide
CAS 545364-85-0C15H12Cl2N2O
(E)-3-(2-Nitrophenyl)-N-(pyridin-3-ylmethyl)prop-2-enamide chemical structure, C15H13N3O3, CAS 1164538-16-2
(E)-3-(2-Nitrophenyl)-N-(pyridin-3-ylmethyl)prop-2-enamide
CAS 1164538-16-2C15H13N3O3
(E)-2-Cyano-3-(4-methoxyphenyl)-N-(pyridin-3-ylmethyl)prop-2-enamide chemical structure, C17H15N3O2, CAS 333345-88-3
(E)-2-Cyano-3-(4-methoxyphenyl)-N-(pyridin-3-ylmethyl)prop-2-enamide
CAS 333345-88-3C17H15N3O2
2-Cyano-3-[4-(difluoromethoxy)phenyl]-N-[(pyridin-3-yl)methyl]prop-2-enamide chemical structure, C17H13F2N3O2, CAS 326615-54-7
2-Cyano-3-[4-(difluoromethoxy)phenyl]-N-[(pyridin-3-yl)methyl]prop-2-enamide
CAS 326615-54-7C17H13F2N3O2
(2Z)-3-(4-Aminophenyl)-N-[(pyridin-3-yl)methyl]prop-2-enamide chemical structure, C15H15N3O, CAS 26034-18-4
(2Z)-3-(4-Aminophenyl)-N-[(pyridin-3-yl)methyl]prop-2-enamide
CAS 26034-18-4C15H15N3O