Murcko scaffold
Benzamide, N-2-thienyl- scaffold
930 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 14
- Chemicals
- 930
- With full pages
- 52
Scaffold SMILES
O=C(Nc1cccs1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 49 to 96 of 930 chemicals
![2-[(4-Fluorobenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxamide chemical structure, C14H13FN2O2S, CAS 314284-08-7](/s/CAIUFIDTELAGHK-UHFFFAOYSA-N.svg)
2-[(4-Fluorobenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxamide
CAS 314284-08-7C14H13FN2O2S
![Ethyl 2-[(4-hydroxyphenyl)carbonylamino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C16H17NO4S, CAS 685853-42-3](/s/DOQLIRAFBXZSKW-UHFFFAOYSA-N.svg)
Ethyl 2-[(4-hydroxyphenyl)carbonylamino]-4,5-dimethylthiophene-3-carboxylate
CAS 685853-42-3C16H17NO4S
Methyl 4,5-dimethyl-2-(3-nitrobenzamido)thiophene-3-carboxylate
CAS 309951-67-5C15H14N2O5S
Methyl 2-(3-chlorobenzamido)-4,5-dimethylthiophene-3-carboxylate
CAS 447409-05-4C15H14ClNO3S
![Ethyl 5-ethyl-2-[(2-methoxybenzoyl)amino]thiophene-3-carboxylate chemical structure, C17H19NO4S, CAS 312939-77-8](/s/DGRILHFTSHFEDF-UHFFFAOYSA-N.svg)
Ethyl 5-ethyl-2-[(2-methoxybenzoyl)amino]thiophene-3-carboxylate
CAS 312939-77-8C17H19NO4S
Ethyl 2-(4-methoxybenzamido)-5-methylthiophene-3-carboxylate
CAS 312939-78-9C16H17NO4S
![Ethyl 2-[(3-chlorobenzoyl)amino]-5-methylthiophene-3-carboxylate chemical structure, C15H14ClNO3S, CAS 312939-88-1](/s/PEJUATIHIJPOIY-UHFFFAOYSA-N.svg)
Ethyl 2-[(3-chlorobenzoyl)amino]-5-methylthiophene-3-carboxylate
CAS 312939-88-1C15H14ClNO3S
Ethyl 2-(2-fluorobenzamido)-5-methylthiophene-3-carboxylate
CAS 312939-91-6C15H14FNO3S
![Ethyl 2-[(2-fluorobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C16H16FNO3S, CAS 312939-92-7](/s/WLQVWIFBSHYTQC-UHFFFAOYSA-N.svg)
Ethyl 2-[(2-fluorobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate
CAS 312939-92-7C16H16FNO3S
![2-[(2-Bromobenzoyl)amino]-5-methyl-3-thiophenecarboxylic acid chemical structure, C13H10BrNO3S, CAS 312940-64-0](/s/OJDCQZYHDUESRB-UHFFFAOYSA-N.svg)
2-[(2-Bromobenzoyl)amino]-5-methyl-3-thiophenecarboxylic acid
CAS 312940-64-0C13H10BrNO3S
2-Benzamido-5-methylthiophene-3-carboxylic acid
CAS 73696-44-3C13H11NO3S
![4,5-Dimethyl-2-[(3-methylbenzoyl)amino]-3-thiophenecarboxylic acid chemical structure, C15H15NO3S, CAS 312940-71-9](/s/JCEZHNZBOGZOGH-UHFFFAOYSA-N.svg)
4,5-Dimethyl-2-[(3-methylbenzoyl)amino]-3-thiophenecarboxylic acid
CAS 312940-71-9C15H15NO3S
4,5-Dimethyl-2-(4-methylbenzamido)thiophene-3-carboxylic acid
CAS 312940-73-1C15H15NO3S
4-Methyl-2-(4-methylbenzamido)-5-propylthiophene-3-carboxylic acid
CAS 312940-74-2C17H19NO3S
![2-[(2-Methoxybenzoyl)amino]-5-methylthiophene-3-carboxylic acid chemical structure, C14H13NO4S, CAS 312940-77-5](/s/WYIRNHADELUALQ-UHFFFAOYSA-N.svg)
2-[(2-Methoxybenzoyl)amino]-5-methylthiophene-3-carboxylic acid
CAS 312940-77-5C14H13NO4S
![2-[(2-Chlorobenzoyl)amino]-5-methylthiophene-3-carboxylic acid chemical structure, C13H10ClNO3S, CAS 380644-18-8](/s/HDKPUQFHQGRBPC-UHFFFAOYSA-N.svg)
2-[(2-Chlorobenzoyl)amino]-5-methylthiophene-3-carboxylic acid
CAS 380644-18-8C13H10ClNO3S
![4-Ethyl-2-{[(4-fluorophenyl)carbonyl]amino}-5-methylthiophene-3-carboxamide chemical structure, C15H15FN2O2S, CAS 5699-05-8](/s/KZSFRFCSRNVXOH-UHFFFAOYSA-N.svg)
4-Ethyl-2-{[(4-fluorophenyl)carbonyl]amino}-5-methylthiophene-3-carboxamide
CAS 5699-05-8C15H15FN2O2S
![Ethyl 2-[(2-ethoxybenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate chemical structure, C18H21NO4S, CAS 314055-25-9](/s/AZJJGWMSLXOBCH-UHFFFAOYSA-N.svg)
Ethyl 2-[(2-ethoxybenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate
CAS 314055-25-9C18H21NO4S
4-tert-Butyl-N-(3-cyano-4,5-dimethylthiophen-2-yl)benzamide
CAS 312704-71-5C18H20N2OS
Ethyl 2-benzamido-5-ethylthiophene-3-carboxylate
CAS 73776-32-6C16H17NO3S
Ethyl 2-(2-chlorobenzamido)-5-ethylthiophene-3-carboxylate
CAS 312528-70-4C16H16ClNO3S
5-Ethyl-2-(3-methylbenzamido)thiophene-3-carboxylic acid
CAS 312528-72-6C15H15NO3S
4-Isobutyl-2-(2-methylbenzamido)thiophene-3-carboxylic acid
CAS 312528-75-9C17H19NO3S
![2-Benzamido-N-[2-(dimethylamino)ethyl]-4,5-dimethylthiophene-3-carboxamide chemical structure, C18H23N3O2S, CAS 331760-64-6](/s/LYDVKJBWLIXPBX-UHFFFAOYSA-N.svg)
2-Benzamido-N-[2-(dimethylamino)ethyl]-4,5-dimethylthiophene-3-carboxamide
CAS 331760-64-6C18H23N3O2S
- Ethyl 5-ethyl-2-[(3-methylbenzoyl)amino]-3-thiophenecarboxylate330460-18-9C17H19NO3S
- 4,5-Dimethyl-2-[3-(trifluoromethyl)benzamido]thiophene-3-carboxamide332874-21-2C15H13F3N2O2S
- N-(3-Cyano-4-ethyl-5-methylthiophen-2-yl)-4-ethoxybenzamide352651-18-4C17H18N2O2S
- Methyl 4,5-dimethyl-2-(2-nitrobenzamido)thiophene-3-carboxylate438609-05-3C15H14N2O5S
- 4,5-Dimethyl-2-[(3-nitrobenzoyl)amino]-3-thiophenecarboxamide346720-11-4C14H13N3O4S
- Methyl 2-[(2-chlorobenzoyl)amino]-4-ethyl-5-methyl-3-thiophenecarboxylate352651-05-9C16H16ClNO3S
- N-(3-Cyano-4-ethyl-5-methylthiophen-2-yl)-2-methylbenzamide355815-48-4C16H16N2OS
- 4-Ethyl-5-methyl-2-[(3-nitrobenzoyl)amino]thiophene-3-carboxamide352651-08-2C15H15N3O4S
- N-(3-Cyano-4,5-dimethyl-2-thienyl)-4-nitro-3-methylbenzamide353782-22-6C15H13N3O3S
- Ethyl 5-ethyl-2-[(2-methylbenzoyl)amino]-3-thiophenecarboxylate380645-28-3C17H19NO3S
- Ethyl 2-[(4-fluorobenzoyl)amino]-4-(2-methylpropyl)thiophene-3-carboxylate461429-94-7C18H20FNO3S
- 2-[(4-Chlorobenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxylic acid461436-98-6C14H12ClNO3S
- 4-tert-Butyl-N-(3-cyano-4-ethyl-5-methylthiophen-2-yl)benzamide298230-94-1C19H22N2OS
- Ethyl 4-isobutyl-2-[(3-methylbenzoyl)amino]-3-thiophenecarboxylate325822-16-0C19H23NO3S
- 2-[(4-tert-Butylbenzoyl)amino]-5-ethylthiophene-3-carboxylic acid461439-35-0C18H21NO3S
- Ethyl 2-[(4-chlorobenzoyl)amino]-5-ethyl-3-thiophenecarboxylate380645-54-5C16H16ClNO3S
- 2-[(4-tert-Butylbenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxylic acid342594-84-7C18H21NO3S
- 2-[(2-Fluorobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylic acid342594-89-2C14H12FNO3S
- 2-(4-Fluorobenzamido)-4,5-dimethylthiophene-3-carboxylic acid342378-69-2C14H12FNO3S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-5-methyl-, 2-hydroxyethyl ester78033-82-6C15H15NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-hydroxyethyl ester78033-83-7C16H17NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(dimethylamino)ethyl ester78033-84-8C18H22N2O3S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(diethylamino)ethyl ester78033-85-9C20H26N2O3S
- 2-Thiopheneacetic acid, 5-benzamido-4-carboxy-3-methyl-105522-85-8C15H13NO5S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1ccco1208 chemicals
O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
O=C(Nc1ccccc1)c1ccoc148 chemicals
c1ccc(CSc2nncs2)cc144 chemicals
O=C(Nc1ccccc1)C1CCCC143 chemicals