Murcko scaffold
Benzamide, N-2-thienyl- scaffold
930 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 14
- Chemicals
- 930
- With full pages
- 52
Scaffold SMILES
O=C(Nc1cccs1)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 97 to 144 of 930 chemicals
![N-{4,5-Dimethyl-3-[(propan-2-ylamino)methyl]thiophen-2-yl}benzamide chemical structure, C17H22N2OS, CAS 333774-34-8](/s/HDVCBLILSKPFSK-UHFFFAOYSA-N.svg)
N-{4,5-Dimethyl-3-[(propan-2-ylamino)methyl]thiophen-2-yl}benzamide
CAS 333774-34-8C17H22N2OS
Ethyl 4-cyano-5-(2-methoxybenzamido)-3-methylthiophene-2-carboxylate
CAS 443123-16-8C17H16N2O4S
![4-Chloro-N-[3-(hydrazinecarbonyl)-4,5-dimethylthiophen-2-yl]benzamide chemical structure, C14H14ClN3O2S, CAS 299962-36-0](/s/OAORPUMYFSEYJN-UHFFFAOYSA-N.svg)
4-Chloro-N-[3-(hydrazinecarbonyl)-4,5-dimethylthiophen-2-yl]benzamide
CAS 299962-36-0C14H14ClN3O2S
![Methyl 4-ethyl-5-methyl-2-[(2-methylbenzoyl)amino]-3-thiophenecarboxylate chemical structure, C17H19NO3S, CAS 354549-75-0](/s/ZKMYNHFNOZBLCB-UHFFFAOYSA-N.svg)
Methyl 4-ethyl-5-methyl-2-[(2-methylbenzoyl)amino]-3-thiophenecarboxylate
CAS 354549-75-0C17H19NO3S
![Methyl 2-[(4-fluorobenzoyl)amino]-5-propan-2-ylthiophene-3-carboxylate chemical structure, C16H16FNO3S, CAS 444997-96-0](/s/FAEQXFJZXJEQFE-UHFFFAOYSA-N.svg)
Methyl 2-[(4-fluorobenzoyl)amino]-5-propan-2-ylthiophene-3-carboxylate
CAS 444997-96-0C16H16FNO3S
![Methyl 2-[(3-chlorobenzoyl)amino]-5-propan-2-ylthiophene-3-carboxylate chemical structure, C16H16ClNO3S, CAS 444999-06-8](/s/IIPZXQNBLUWECZ-UHFFFAOYSA-N.svg)
Methyl 2-[(3-chlorobenzoyl)amino]-5-propan-2-ylthiophene-3-carboxylate
CAS 444999-06-8C16H16ClNO3S
![Methyl 2-[(3,4-dimethylbenzoyl)amino]-5-isopropylthiophene-3-carboxylate chemical structure, C18H21NO3S, CAS 444999-25-1](/s/DWLIEVPOABZEMS-UHFFFAOYSA-N.svg)
Methyl 2-[(3,4-dimethylbenzoyl)amino]-5-isopropylthiophene-3-carboxylate
CAS 444999-25-1C18H21NO3S
![Methyl 2-[(2-chlorobenzoyl)amino]-5-isopropylthiophene-3-carboxylate chemical structure, C16H16ClNO3S, CAS 495383-32-9](/s/QNMZBHOTXBXYLT-UHFFFAOYSA-N.svg)
Methyl 2-[(2-chlorobenzoyl)amino]-5-isopropylthiophene-3-carboxylate
CAS 495383-32-9C16H16ClNO3S
![Methyl 5-isopropyl-2-[(4-methoxybenzoyl)amino]thiophene-3-carboxylate chemical structure, C17H19NO4S, CAS 445001-71-8](/s/ZXQQKJIPOPQZOU-UHFFFAOYSA-N.svg)
Methyl 5-isopropyl-2-[(4-methoxybenzoyl)amino]thiophene-3-carboxylate
CAS 445001-71-8C17H19NO4S
![Methyl 2-[(2-chlorobenzoyl)amino]-5-ethylthiophene-3-carboxylate chemical structure, C15H14ClNO3S, CAS 445004-35-3](/s/YLFJBKDCYALZFQ-UHFFFAOYSA-N.svg)
Methyl 2-[(2-chlorobenzoyl)amino]-5-ethylthiophene-3-carboxylate
CAS 445004-35-3C15H14ClNO3S
![Methyl 5-ethyl-2-[(4-methyl-3-nitrobenzoyl)amino]thiophene-3-carboxylate chemical structure, C16H16N2O5S, CAS 445004-69-3](/s/DFMKCLLVUMPTMS-UHFFFAOYSA-N.svg)
Methyl 5-ethyl-2-[(4-methyl-3-nitrobenzoyl)amino]thiophene-3-carboxylate
CAS 445004-69-3C16H16N2O5S
Methyl 2-({3-nitrobenzoyl}amino)-5-methylthiophene-3-carboxylate
CAS 445006-65-5C14H12N2O5S
![Methyl 5-methyl-2-[(4-propan-2-yloxybenzoyl)amino]thiophene-3-carboxylate chemical structure, C17H19NO4S, CAS 495395-27-2](/s/CVYPIRBMPUVKAD-UHFFFAOYSA-N.svg)
Methyl 5-methyl-2-[(4-propan-2-yloxybenzoyl)amino]thiophene-3-carboxylate
CAS 495395-27-2C17H19NO4S
![Ethyl 5-methyl-2-[(2-methyl-3-nitrobenzoyl)amino]thiophene-3-carboxylate chemical structure, C16H16N2O5S, CAS 445013-20-7](/s/KHIZBCOAJQRUPS-UHFFFAOYSA-N.svg)
Ethyl 5-methyl-2-[(2-methyl-3-nitrobenzoyl)amino]thiophene-3-carboxylate
CAS 445013-20-7C16H16N2O5S
Methyl 2-(3,5-dimethylbenzamido)-4,5-dimethylthiophene-3-carboxylate
CAS 495396-10-6C17H19NO3S
![5-Ethyl-2-[(4-methoxybenzoyl)amino]-3-thiophenecarboxamide chemical structure, C15H16N2O3S, CAS 590399-72-7](/s/KVFWTEBBTQBYNR-UHFFFAOYSA-N.svg)
5-Ethyl-2-[(4-methoxybenzoyl)amino]-3-thiophenecarboxamide
CAS 590399-72-7C15H16N2O3S
![2-[(2,4-Dimethoxybenzoyl)amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C16H18N2O4S, CAS 544438-15-5](/s/URQPMGQNHQONEO-UHFFFAOYSA-N.svg)
2-[(2,4-Dimethoxybenzoyl)amino]-4,5-dimethylthiophene-3-carboxamide
CAS 544438-15-5C16H18N2O4S
Methyl 4,5-dimethyl-2-(3-methylbenzamido)thiophene-3-carboxylate
CAS 544459-28-1C16H17NO3S
![Isopropyl 4-ethyl-2-[(3-fluorobenzoyl)amino]-5-methyl-3-thiophenecarboxylate chemical structure, C18H20FNO3S, CAS 544680-89-9](/s/FGQWCRYUIHYMQW-UHFFFAOYSA-N.svg)
Isopropyl 4-ethyl-2-[(3-fluorobenzoyl)amino]-5-methyl-3-thiophenecarboxylate
CAS 544680-89-9C18H20FNO3S
![4,5-Dimethyl-2-[(3-methyl-4-nitrobenzoyl)amino]thiophene-3-carboxamide chemical structure, C15H15N3O4S, CAS 544662-27-3](/s/ZATYRWZSGVMAIN-UHFFFAOYSA-N.svg)
4,5-Dimethyl-2-[(3-methyl-4-nitrobenzoyl)amino]thiophene-3-carboxamide
CAS 544662-27-3C15H15N3O4S
![2-[(3,5-Dimethoxybenzoyl)amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C16H18N2O4S, CAS 383381-28-0](/s/HGHZTICEGOKLDQ-UHFFFAOYSA-N.svg)
2-[(3,5-Dimethoxybenzoyl)amino]-4,5-dimethylthiophene-3-carboxamide
CAS 383381-28-0C16H18N2O4S
Ethyl 2-(3-fluorobenzamido)-4,5-dimethylthiophene-3-carboxylate
CAS 459219-38-6C16H16FNO3S
![2-[(2-Chloro-4,5-difluorobenzoyl)amino]-4,5-dimethylthiophene-3-carboxamide chemical structure, C14H11ClF2N2O2S, CAS 670230-79-2](/s/WLRPVTMMMGENGV-UHFFFAOYSA-N.svg)
2-[(2-Chloro-4,5-difluorobenzoyl)amino]-4,5-dimethylthiophene-3-carboxamide
CAS 670230-79-2C14H11ClF2N2O2S
2-Benzamido-5-ethylthiophene-3-carboxylic acid
CAS 73696-46-5C14H13NO3S
- Propan-2-yl 2-[(4-fluorobenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate438613-75-3C17H18FNO3S
- 2-[(3,5-Dimethoxybenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide303139-14-2C17H20N2O4S
- 4-Ethyl-5-methyl-2-[(2-methylbenzoyl)amino]thiophene-3-carboxamide420089-81-2C16H18N2O2S
- 2-[(4-tert-Butylbenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide352677-56-6C19H24N2O2S
- Methyl 2-(3,4-dimethylbenzamido)-4,5-dimethylthiophene-3-carboxylate420091-48-1C17H19NO3S
- Methyl 4-ethyl-2-{[(4-fluorophenyl)carbonyl]amino}-5-methylthiophene-3-carboxylate420092-04-2C16H16FNO3S
- Methyl 4-carbamoyl-5-(3,4-dimethylbenzamido)-3-methylthiophene-2-carboxylate420093-14-7C17H18N2O4S
- Methyl 2-[(3,4-dimethylbenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxylate303138-54-7C18H21NO3S
- Isopropyl 2-[(3-fluorobenzoyl)amino]-4,5-dimethyl-3-thiophenecarboxylate353785-06-5C17H18FNO3S
- 2,4-Dichloro-N-(3-cyano-4-ethyl-5-methylthiophen-2-yl)benzamide420094-01-5C15H12Cl2N2OS
- 2-[(2,4-Dimethoxybenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide362609-54-9C17H20N2O4S
- Methyl 4-ethyl-2-[(2-methoxybenzoyl)amino]-5-methylthiophene-3-carboxylate362602-80-0C17H19NO4S
- Ethyl 2-[(4-ethoxybenzoyl)amino]-4,5-dimethylthiophene-3-carboxylate362601-92-1C18H21NO4S
- 2-[(4-Chlorobenzoyl)amino]-4-ethyl-5-methylthiophene-3-carboxamide418778-44-6C15H15ClN2O2S
- Ethyl 4-ethyl-2-[(4-fluorobenzoyl)amino]-5-methylthiophene-3-carboxylate424817-37-8C17H18FNO3S
- Isopropyl 4-ethyl-2-[(4-fluorobenzoyl)amino]-5-methyl-3-thiophenecarboxylate353479-48-8C18H20FNO3S
- 4-Ethyl-2-[(4-methoxybenzoyl)amino]-5-methylthiophene-3-carboxamide424810-86-6C16H18N2O3S
- Methyl 2-[(2,6-difluorobenzoyl)amino]-5-propylthiophene-3-carboxylate351155-36-7C16H15F2NO3S
- Ethyl 2-[(3-ethoxybenzoyl)amino]-5-ethylthiophene-3-carboxylate350989-20-7C18H21NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-5-methyl-, 2-hydroxyethyl ester78033-82-6C15H15NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-hydroxyethyl ester78033-83-7C16H17NO4S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(dimethylamino)ethyl ester78033-84-8C18H22N2O3S
- 3-Thiophenecarboxylic acid, 2-(benzoylamino)-4,5-dimethyl-, 2-(diethylamino)ethyl ester78033-85-9C20H26N2O3S
- 2-Thiopheneacetic acid, 5-benzamido-4-carboxy-3-methyl-105522-85-8C15H13NO5S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1ccco1208 chemicals
O=C(Nc1ccccc1)c1cccs1150 chemicals
O=C(Nc1nccs1)c1ccccc1121 chemicals![Scaffold O=C(N=c1[nH]ncs1)c1ccccc1](/scaffold/RWOUBULBQYRRNL-UHFFFAOYSA-N/structure.svg)
O=C(N=c1[nH]ncs1)c1ccccc187 chemicals
c1ccc(OCc2ccco2)cc175 chemicals
O=S(=O)(Nc1nccs1)c1ccccc161 chemicals![Scaffold c1ccc(CSc2ncn[nH]2)cc1](/scaffold/IQQYSQRJFHUASD-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2ncn[nH]2)cc160 chemicals![Scaffold O=C(Nc1ccccc1)c1cc[nH]n1](/scaffold/WMZYZYFPPQOFKY-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)c1cc[nH]n160 chemicals
O=C(Nc1ccccc1)C1CCCO150 chemicals
O=C(Nc1ccccc1)c1ccoc148 chemicals
c1ccc(CSc2nncs2)cc144 chemicals
O=C(Nc1ccccc1)C1CCCC143 chemicals