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Murcko scaffold

Ring system with 3 rings and 25 atoms

40 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
40
With full pages
6
Scaffold SMILES

O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 40 of 40 chemicals

Ethyl 4-(N-(m-tolyl)-N-tosylglycyl)piperazine-1-carboxylate chemical structure, C23H29N3O5S, CAS 505051-15-0
Ethyl 4-(N-(m-tolyl)-N-tosylglycyl)piperazine-1-carboxylate
CAS 505051-15-0C23H29N3O5S
Ethyl 4-{N-(phenylsulfonyl)-N-[3-(trifluoromethyl)phenyl]glycyl}piperazine-1-carboxylate chemical structure, C22H24F3N3O5S, CAS 361199-71-5
Ethyl 4-{N-(phenylsulfonyl)-N-[3-(trifluoromethyl)phenyl]glycyl}piperazine-1-carboxylate
CAS 361199-71-5C22H24F3N3O5S
Ethyl 4-[N-(2,3-dichlorophenyl)-N-(phenylsulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C21H23Cl2N3O5S, CAS 361199-87-3
Ethyl 4-[N-(2,3-dichlorophenyl)-N-(phenylsulfonyl)glycyl]piperazine-1-carboxylate
CAS 361199-87-3C21H23Cl2N3O5S
4-Chloro-N-(3-chlorophenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C19H21Cl2N3O3S, CAS 694506-62-2
4-Chloro-N-(3-chlorophenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 694506-62-2C19H21Cl2N3O3S
Ethyl 4-{N-(3,4-dimethoxyphenyl)-N-[(4-methylphenyl)sulfonyl]glycyl}piperazine-1-carboxylate chemical structure, C24H31N3O7S, CAS 496935-82-1
Ethyl 4-{N-(3,4-dimethoxyphenyl)-N-[(4-methylphenyl)sulfonyl]glycyl}piperazine-1-carboxylate
CAS 496935-82-1C24H31N3O7S
4-Fluoro-N-(4-methylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C20H24FN3O3S, CAS 367917-95-1
4-Fluoro-N-(4-methylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 367917-95-1C20H24FN3O3S
Ethyl 4-[2-(3,5-dimethyl-N-(4-methylphenyl)sulfonylanilino)acetyl]piperazine-1-carboxylate chemical structure, C24H31N3O5S, CAS 6487-19-0
Ethyl 4-[2-(3,5-dimethyl-N-(4-methylphenyl)sulfonylanilino)acetyl]piperazine-1-carboxylate
CAS 6487-19-0C24H31N3O5S
N-(4-Fluorophenyl)-4-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C20H24FN3O3S, CAS 335208-29-2
N-(4-Fluorophenyl)-4-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 335208-29-2C20H24FN3O3S
Ethyl 4-{N-(2,3-dimethylphenyl)-N-[(4-methylphenyl)sulfonyl]glycyl}piperazine-1-carboxylate chemical structure, C24H31N3O5S, CAS 530121-35-8
Ethyl 4-{N-(2,3-dimethylphenyl)-N-[(4-methylphenyl)sulfonyl]glycyl}piperazine-1-carboxylate
CAS 530121-35-8C24H31N3O5S
N-(3,4-Dimethoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C21H27N3O5S, CAS 425680-23-5
N-(3,4-Dimethoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 425680-23-5C21H27N3O5S
4-Ethoxy-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-N-phenylbenzenesulfonamide chemical structure, C21H27N3O4S, CAS 641999-28-2
4-Ethoxy-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-N-phenylbenzenesulfonamide
CAS 641999-28-2C21H27N3O4S
N-(2-Ethoxyphenyl)-4-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C22H29N3O4S, CAS 335208-39-4
N-(2-Ethoxyphenyl)-4-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 335208-39-4C22H29N3O4S
N-(2,5-Dimethylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C21H27N3O3S, CAS 425668-71-9
N-(2,5-Dimethylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 425668-71-9C21H27N3O3S
4-Ethoxy-N-(4-methylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C22H29N3O4S, CAS 335212-11-8
4-Ethoxy-N-(4-methylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 335212-11-8C22H29N3O4S
N-(3-Chloro-4-methoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C20H24ClN3O4S, CAS 335392-77-3
N-(3-Chloro-4-methoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 335392-77-3C20H24ClN3O4S
Ethyl 4-{[3-nitro(phenylsulfonyl)anilino]acetyl}-1-piperazinecarboxylate chemical structure, C21H24N4O7S, CAS 366830-17-3
Ethyl 4-{[3-nitro(phenylsulfonyl)anilino]acetyl}-1-piperazinecarboxylate
CAS 366830-17-3C21H24N4O7S
Ethyl 4-[N-(2-chlorophenyl)-N-(phenylsulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C21H24ClN3O5S, CAS 333741-62-1
Ethyl 4-[N-(2-chlorophenyl)-N-(phenylsulfonyl)glycyl]piperazine-1-carboxylate
CAS 333741-62-1C21H24ClN3O5S
Ethyl 4-[N-(3-methylphenyl)-N-(phenylsulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C22H27N3O5S, CAS 460044-64-8
Ethyl 4-[N-(3-methylphenyl)-N-(phenylsulfonyl)glycyl]piperazine-1-carboxylate
CAS 460044-64-8C22H27N3O5S
N-(2,5-Dimethoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C21H27N3O5S, CAS 333746-02-4
N-(2,5-Dimethoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 333746-02-4C21H27N3O5S
Ethyl 4-[2-[(2,4-dimethylphenyl)(phenylsulfonyl)amino]acetyl]-1-piperazinecarboxylate chemical structure, C23H29N3O5S, CAS 333747-87-8
Ethyl 4-[2-[(2,4-dimethylphenyl)(phenylsulfonyl)amino]acetyl]-1-piperazinecarboxylate
CAS 333747-87-8C23H29N3O5S
N-(3,5-Dimethylphenyl)-3,4-dimethoxy-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C23H31N3O5S, CAS 412919-94-9
N-(3,5-Dimethylphenyl)-3,4-dimethoxy-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 412919-94-9C23H31N3O5S
N-(3,4-Dimethoxyphenyl)-4-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C22H29N3O5S, CAS 428487-54-1
N-(3,4-Dimethoxyphenyl)-4-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 428487-54-1C22H29N3O5S
Ethyl 4-[N-(3,4-dimethylphenyl)-N-(phenylsulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C23H29N3O5S, CAS 428473-85-2
Ethyl 4-[N-(3,4-dimethylphenyl)-N-(phenylsulfonyl)glycyl]piperazine-1-carboxylate
CAS 428473-85-2C23H29N3O5S
N-(3,4-Dimethylphenyl)-4-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide chemical structure, C22H29N3O3S, CAS 426232-75-9
N-(3,4-Dimethylphenyl)-4-methyl-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]benzenesulfonamide
CAS 426232-75-9C22H29N3O3S