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Murcko scaffold

2-(2,5-Dioxo-3-pyrrolidinyl)-1H-isoindole-1,3(2H)-dione scaffold

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
15
With full pages
4
Scaffold SMILES

O=C1CC(N2C(=O)c3ccccc3C2=O)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(2,5-Dioxo-3-pyrrolidinyl)-1H-isoindole-1,3(2H)-dione page
Murcko scaffold O=C1CC(N2C(=O)c3ccccc3C2=O)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

2-(2,5-Dioxo-3-pyrrolidinyl)-1H-isoindole-1,3(2H)-dione chemical structure, C12H8N2O4, CAS 303-16-2
2-(2,5-Dioxo-3-pyrrolidinyl)-1H-isoindole-1,3(2H)-dione
CAS 303-16-2C12H8N2O4
2-(4-Methyl-2,5-dioxo-3-pyrrolidinyl)-1H-isoindole-1,3(2H)-dione chemical structure, C13H10N2O4, CAS 303-08-2
2-(4-Methyl-2,5-dioxo-3-pyrrolidinyl)-1H-isoindole-1,3(2H)-dione
CAS 303-08-2C13H10N2O4
(S)-4-Amino-2-(2,5-dioxopyrrolidin-3-yl)isoindoline-1,3-dione chemical structure, C12H9N3O4, CAS 2133815-50-4
(S)-4-Amino-2-(2,5-dioxopyrrolidin-3-yl)isoindoline-1,3-dione
CAS 2133815-50-4C12H9N3O4
4-Amino-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C12H9N3O4, CAS 2133815-88-8
4-Amino-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2133815-88-8C12H9N3O4
5-Amino-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C12H9N3O4, CAS 2365400-84-4
5-Amino-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2365400-84-4C12H9N3O4
2-(2,5-Dioxopyrrolidin-3-yl)-4-fluoro-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C12H7FN2O4, CAS 2919946-21-5
2-(2,5-Dioxopyrrolidin-3-yl)-4-fluoro-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2919946-21-5C12H7FN2O4
2-(2,5-Dioxopyrrolidin-3-yl)-5-fluoro-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C12H7FN2O4, CAS 2241582-93-2
2-(2,5-Dioxopyrrolidin-3-yl)-5-fluoro-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2241582-93-2C12H7FN2O4
2-(2,5-Dioxopyrrolidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-4-carboxylic acid chemical structure, C13H8N2O6, CAS 2913240-92-1
2-(2,5-Dioxopyrrolidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-4-carboxylic acid
CAS 2913240-92-1C13H8N2O6
2-(2,5-Dioxopyrrolidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid chemical structure, C13H8N2O6, CAS 2913240-96-5
2-(2,5-Dioxopyrrolidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
CAS 2913240-96-5C13H8N2O6
4-Bromo-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C12H7BrN2O4, CAS 2913241-90-2
4-Bromo-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2913241-90-2C12H7BrN2O4
5-Bromo-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C12H7BrN2O4, CAS 2913243-84-0
5-Bromo-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2913243-84-0C12H7BrN2O4
2-(2,5-Dioxopyrrolidin-3-yl)-5-hydroxyisoindoline-1,3-dione chemical structure, C12H8N2O5, CAS 2923840-87-1
2-(2,5-Dioxopyrrolidin-3-yl)-5-hydroxyisoindoline-1,3-dione
CAS 2923840-87-1C12H8N2O5
2-(2,5-Dioxopyrrolidin-3-yl)-4-hydroxyisoindoline-1,3-dione chemical structure, C12H8N2O5, CAS 2923840-37-1
2-(2,5-Dioxopyrrolidin-3-yl)-4-hydroxyisoindoline-1,3-dione
CAS 2923840-37-1C12H8N2O5
4-(Aminomethyl)-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride chemical structure, C13H12ClN3O4, CAS 2956478-76-3
4-(Aminomethyl)-2-(2,5-dioxopyrrolidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
CAS 2956478-76-3C13H12ClN3O4
2-(2,5-Dioxopyrrolidin-3-yl)-5,6-difluoro-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C12H6F2N2O4, CAS 2923839-78-3
2-(2,5-Dioxopyrrolidin-3-yl)-5,6-difluoro-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2923839-78-3C12H6F2N2O4