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Murcko scaffold

Ring system with 4 rings and 20 atoms

33 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
20
Chemicals
33
With full pages
5
Scaffold SMILES

C1=CC(c2ccccc2)c2ccc3ccccc3c2O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C1=CC(c2ccccc2)c2ccc3ccccc3c2O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

2-Amino-4-(3,4,5-trimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C23H20N2O4, CAS 339062-56-5
2-Amino-4-(3,4,5-trimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 339062-56-5C23H20N2O4
2-Amino-4-(2,4-dichlorophenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C20H12Cl2N2O, CAS 346436-68-8
2-Amino-4-(2,4-dichlorophenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 346436-68-8C20H12Cl2N2O
2-Amino-4-(4-methoxyphenyl)-4H-benzo(h)chromene-3-carbonitrile chemical structure, C21H16N2O2, CAS 119825-06-8
2-Amino-4-(4-methoxyphenyl)-4H-benzo(h)chromene-3-carbonitrile
CAS 119825-06-8C21H16N2O2
2-Amino-4-(4-fluorophenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C20H13FN2O, CAS 326915-26-8
2-Amino-4-(4-fluorophenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 326915-26-8C20H13FN2O
2-Amino-4-[4-(trifluoromethyl)phenyl]-4H-benzo[h]chromene-3-carbonitrile chemical structure, C21H13F3N2O, CAS 149550-39-0
2-Amino-4-[4-(trifluoromethyl)phenyl]-4H-benzo[h]chromene-3-carbonitrile
CAS 149550-39-0C21H13F3N2O
2-Amino-4-(4-propan-2-ylphenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C23H20N2O, CAS 332056-08-3
2-Amino-4-(4-propan-2-ylphenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 332056-08-3C23H20N2O
AC1Mdnvo chemical structure, C20H12ClFN2O, CAS 5303-72-0
AC1Mdnvo
CAS 5303-72-0C20H12ClFN2O
2-Amino-4-(2-ethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C22H18N2O2, CAS 5304-42-7
2-Amino-4-(2-ethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 5304-42-7C22H18N2O2
2-Amino-4-(3-methoxyphenyl)-4H-benzo(h)chromene-3-carbonitrile chemical structure, C21H16N2O2, CAS 149550-57-2
2-Amino-4-(3-methoxyphenyl)-4H-benzo(h)chromene-3-carbonitrile
CAS 149550-57-2C21H16N2O2
(4R)-2-Amino-4-(2,3-dimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C22H18N2O3, CAS 5309-79-5
(4R)-2-Amino-4-(2,3-dimethoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 5309-79-5C22H18N2O3
4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-4-(4-nitrophenyl)- chemical structure, C20H13N3O3, CAS 149550-37-8
4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-4-(4-nitrophenyl)-
CAS 149550-37-8C20H13N3O3
2-Amino-4-(2,3-dichlorophenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C20H12Cl2N2O, CAS 331977-98-1
2-Amino-4-(2,3-dichlorophenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 331977-98-1C20H12Cl2N2O
2-Amino-4-(3-fluorophenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C20H13FN2O, CAS 149550-42-5
2-Amino-4-(3-fluorophenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 149550-42-5C20H13FN2O
Ethyl 2-amino-4-phenyl-4H-benzo[h]chromene-3-carboxylate chemical structure, C22H19NO3, CAS 171286-13-8
Ethyl 2-amino-4-phenyl-4H-benzo[h]chromene-3-carboxylate
CAS 171286-13-8C22H19NO3
2-Amino-4-(3-methoxy-4-prop-2-enoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C24H20N2O3, CAS 592514-26-6
2-Amino-4-(3-methoxy-4-prop-2-enoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 592514-26-6C24H20N2O3
2-Amino-4-(4-hydroxy-3-methoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C21H16N2O3, CAS 331869-77-3
2-Amino-4-(4-hydroxy-3-methoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 331869-77-3C21H16N2O3
2-Amino-4-(3-nitrophenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C20H13N3O3, CAS 149550-36-7
2-Amino-4-(3-nitrophenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 149550-36-7C20H13N3O3
2-Amino-4-(3,4-dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile chemical structure, C22H18N2O3, CAS 149550-68-5
2-Amino-4-(3,4-dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-3-carbonitrile
CAS 149550-68-5C22H18N2O3
2-Amino-4-(3-ethoxy-4-hydroxyphenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C22H18N2O3, CAS 333341-51-8
2-Amino-4-(3-ethoxy-4-hydroxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 333341-51-8C22H18N2O3
4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-4-(3-chlorophenyl)- chemical structure, C20H13ClN2O, CAS 149550-44-7
4H-Naphtho[1,2-b]pyran-3-carbonitrile, 2-amino-4-(3-chlorophenyl)-
CAS 149550-44-7C20H13ClN2O
2-Amino-4-(3-bromo-4-hydroxy-5-methoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C21H15BrN2O3, CAS 332053-47-1
2-Amino-4-(3-bromo-4-hydroxy-5-methoxyphenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 332053-47-1C21H15BrN2O3
2-Amino-4-phenyl-4H-benzo[h]chromene-3-carbonitrile chemical structure, C20H14N2O, CAS 119825-05-7
2-Amino-4-phenyl-4H-benzo[h]chromene-3-carbonitrile
CAS 119825-05-7C20H14N2O
2-Amino-4-(3,4-diethoxy-phenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C24H22N2O3, CAS 336180-43-9
2-Amino-4-(3,4-diethoxy-phenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 336180-43-9C24H22N2O3
2-Amino-4-(4-bromophenyl)-4H-benzo[h]chromene-3-carbonitrile chemical structure, C20H13BrN2O, CAS 860787-48-0
2-Amino-4-(4-bromophenyl)-4H-benzo[h]chromene-3-carbonitrile
CAS 860787-48-0C20H13BrN2O