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Murcko scaffold

6,7-Dihydro-5H-isoquinolin-8-one scaffold

17 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
17
With full pages
5
Scaffold SMILES

O=C1CCCc2ccncc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 6,7-Dihydro-5H-isoquinolin-8-one page
Murcko scaffold O=C1CCCc2ccncc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 17 of 17 chemicals

6,7-Dihydro-5H-isoquinolin-8-one chemical structure, C9H9NO, CAS 21917-88-4
6,7-Dihydro-5H-isoquinolin-8-one
CAS 21917-88-4C9H9NO
Methyl 8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate chemical structure, C11H11NO3, CAS 151330-02-8
Methyl 8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate
CAS 151330-02-8C11H11NO3
3-Methoxy-6,7-dihydro-5H-isoquinolin-8-one chemical structure, C10H11NO2, CAS 56053-58-8
3-Methoxy-6,7-dihydro-5H-isoquinolin-8-one
CAS 56053-58-8C10H11NO2
1,3-Dimethyl-6,7-dihydro-5H-isoquinolin-8-one chemical structure, C11H13NO, CAS 97235-10-4
1,3-Dimethyl-6,7-dihydro-5H-isoquinolin-8-one
CAS 97235-10-4C11H13NO
1,3,6,6-Tetramethyl-6,7-dihydroisoquinolin-8(5H)-one chemical structure, C13H17NO, CAS 55713-38-7
1,3,6,6-Tetramethyl-6,7-dihydroisoquinolin-8(5H)-one
CAS 55713-38-7C13H17NO
5,6,7,8-Tetrahydroisoquinolin-8-one hydrochloride chemical structure, C9H10ClNO, CAS 135311-97-6
5,6,7,8-Tetrahydroisoquinolin-8-one hydrochloride
CAS 135311-97-6C9H10ClNO
Ethyl 8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate chemical structure, C12H13NO3, CAS 864499-11-6
Ethyl 8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate
CAS 864499-11-6C12H13NO3
4-Bromo-6,7-dihydro-8(5H)-isoquinolinone chemical structure, C9H8BrNO, CAS 1428651-86-8
4-Bromo-6,7-dihydro-8(5H)-isoquinolinone
CAS 1428651-86-8C9H8BrNO
Methyl 4-bromo-8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate chemical structure, C11H10BrNO3, CAS 1428651-85-7
Methyl 4-bromo-8-oxo-5,6,7,8-tetrahydroisoquinoline-7-carboxylate
CAS 1428651-85-7C11H10BrNO3
4-Bromo-7-fluoro-6,7-dihydro-8(5H)-isoquinolinone chemical structure, C9H7BrFNO, CAS 1428652-13-4
4-Bromo-7-fluoro-6,7-dihydro-8(5H)-isoquinolinone
CAS 1428652-13-4C9H7BrFNO
Methyl 4-bromo-5,6,7,8-tetrahydro-7-methyl-8-oxo-7-isoquinolinecarboxylate chemical structure, C12H12BrNO3, CAS 1428652-03-2
Methyl 4-bromo-5,6,7,8-tetrahydro-7-methyl-8-oxo-7-isoquinolinecarboxylate
CAS 1428652-03-2C12H12BrNO3
4-Bromo-6,7-dihydro-7-methyl-8(5H)-isoquinolinone chemical structure, C10H10BrNO, CAS 1428652-04-3
4-Bromo-6,7-dihydro-7-methyl-8(5H)-isoquinolinone
CAS 1428652-04-3C10H10BrNO
3-Chloro-5,6,7,8-tetrahydroisoquinolin-8-one chemical structure, C9H8ClNO, CAS 1256821-77-8
3-Chloro-5,6,7,8-tetrahydroisoquinolin-8-one
CAS 1256821-77-8C9H8ClNO
Monascopyridine C chemical structure, C20H27NO3, CAS 909094-27-5
Monascopyridine C
CAS 909094-27-5C20H27NO3
Monascopyridine D chemical structure, C22H31NO3, CAS 909094-28-6
Monascopyridine D
CAS 909094-28-6C22H31NO3
3-Methyl-5,6,7,8-tetrahydroisoquinolin-8-one chemical structure, C10H11NO, CAS 1823383-57-8
3-Methyl-5,6,7,8-tetrahydroisoquinolin-8-one
CAS 1823383-57-8C10H11NO
3-Methyl-5,6,7,8-tetrahydroisoquinolin-8-one hydrochloride chemical structure, C10H12ClNO, CAS 2060035-46-1
3-Methyl-5,6,7,8-tetrahydroisoquinolin-8-one hydrochloride
CAS 2060035-46-1C10H12ClNO