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Murcko scaffold

Ring system with 2 rings and 19 atoms

18 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
19
Chemicals
18
With full pages
3
Scaffold SMILES

O=C(C=CC(=O)c1ccccc1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=CC(=O)c1ccccc1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

(E)-N-(4-tert-Butylphenyl)-4-(4-ethoxyphenyl)-4-oxobut-2-enamide chemical structure, C22H25NO3, CAS 331461-85-9
(E)-N-(4-tert-Butylphenyl)-4-(4-ethoxyphenyl)-4-oxobut-2-enamide
CAS 331461-85-9C22H25NO3
(E)-4-(4-Ethoxyphenyl)-4-oxo-N-[4-(trifluoromethoxy)phenyl]but-2-enamide chemical structure, C19H16F3NO4, CAS 331461-86-0
(E)-4-(4-Ethoxyphenyl)-4-oxo-N-[4-(trifluoromethoxy)phenyl]but-2-enamide
CAS 331461-86-0C19H16F3NO4
(E)-4-(4-Ethoxyphenyl)-N-(4-ethylphenyl)-4-oxo-2-butenamide chemical structure, C20H21NO3, CAS 331461-83-7
(E)-4-(4-Ethoxyphenyl)-N-(4-ethylphenyl)-4-oxo-2-butenamide
CAS 331461-83-7C20H21NO3
N-(4-Bromophenyl)-4-(4-ethoxyphenyl)-4-oxo-2-butenamide chemical structure, C18H16BrNO3, CAS 331461-87-1
N-(4-Bromophenyl)-4-(4-ethoxyphenyl)-4-oxo-2-butenamide
CAS 331461-87-1C18H16BrNO3
2-Butenamide, 2-methyl-4-oxo-4-phenyl-N-(3-(trifluoromethyl)phenyl)- chemical structure, C18H14F3NO2, CAS 58182-72-2
2-Butenamide, 2-methyl-4-oxo-4-phenyl-N-(3-(trifluoromethyl)phenyl)-
CAS 58182-72-2C18H14F3NO2
(2E)-4-(2,5-Dimethylphenyl)-4-oxo-N-phenyl-2-butenamide chemical structure, C18H17NO2, CAS 81353-16-4
(2E)-4-(2,5-Dimethylphenyl)-4-oxo-N-phenyl-2-butenamide
CAS 81353-16-4C18H17NO2
4-(4-Ethoxyphenyl)-N-(4-fluorophenyl)-4-oxo-2-butenamide chemical structure, C18H16FNO3, CAS 331461-93-9
4-(4-Ethoxyphenyl)-N-(4-fluorophenyl)-4-oxo-2-butenamide
CAS 331461-93-9C18H16FNO3
2-Acetyl-4-oxo-N,4-diphenylbut-2-enamide chemical structure, C18H15NO3, CAS 89201-30-9
2-Acetyl-4-oxo-N,4-diphenylbut-2-enamide
CAS 89201-30-9C18H15NO3
2-Acetyl-4-(4-chlorophenyl)-4-oxo-N-phenylbut-2-enamide chemical structure, C18H14ClNO3, CAS 89201-31-0
2-Acetyl-4-(4-chlorophenyl)-4-oxo-N-phenylbut-2-enamide
CAS 89201-31-0C18H14ClNO3
2-Acetyl-4-(4-bromophenyl)-4-oxo-N-phenylbut-2-enamide chemical structure, C18H14BrNO3, CAS 89201-32-1
2-Acetyl-4-(4-bromophenyl)-4-oxo-N-phenylbut-2-enamide
CAS 89201-32-1C18H14BrNO3
2-Acetyl-4-(4-nitrophenyl)-4-oxo-N-phenylbut-2-enamide chemical structure, C18H14N2O5, CAS 89201-33-2
2-Acetyl-4-(4-nitrophenyl)-4-oxo-N-phenylbut-2-enamide
CAS 89201-33-2C18H14N2O5
2-Acetyl-4-(4-methylphenyl)-4-oxo-N-phenylbut-2-enamide chemical structure, C19H17NO3, CAS 89201-34-3
2-Acetyl-4-(4-methylphenyl)-4-oxo-N-phenylbut-2-enamide
CAS 89201-34-3C19H17NO3
2-Acetyl-4-(4-methoxyphenyl)-4-oxo-N-phenylbut-2-enamide chemical structure, C19H17NO4, CAS 89201-35-4
2-Acetyl-4-(4-methoxyphenyl)-4-oxo-N-phenylbut-2-enamide
CAS 89201-35-4C19H17NO4
2-Acetyl-4-[4-(dimethylamino)phenyl]-4-oxo-N-phenylbut-2-enamide chemical structure, C20H20N2O3, CAS 89201-36-5
2-Acetyl-4-[4-(dimethylamino)phenyl]-4-oxo-N-phenylbut-2-enamide
CAS 89201-36-5C20H20N2O3
N-(3-Chlorophenyl)-4-(4-chlorophenyl)-4-oxobut-2-enamide chemical structure, C16H11Cl2NO2, CAS 116356-00-4
N-(3-Chlorophenyl)-4-(4-chlorophenyl)-4-oxobut-2-enamide
CAS 116356-00-4C16H11Cl2NO2
2-{[4-(4-Methylphenyl)-4-oxobut-2-enoyl]amino}benzoic acid chemical structure, C18H15NO4, CAS 70596-64-4
2-{[4-(4-Methylphenyl)-4-oxobut-2-enoyl]amino}benzoic acid
CAS 70596-64-4C18H15NO4
4-(3,4-Dichlorophenyl)-N-(4-methylphenyl)-4-oxobut-2-enamide chemical structure, C17H13Cl2NO2, CAS 88018-16-0
4-(3,4-Dichlorophenyl)-N-(4-methylphenyl)-4-oxobut-2-enamide
CAS 88018-16-0C17H13Cl2NO2
N-(4-Chlorophenyl)-4-oxo-4-phenylbut-2-enamide chemical structure, C16H12ClNO2, CAS 3156-01-2
N-(4-Chlorophenyl)-4-oxo-4-phenylbut-2-enamide
CAS 3156-01-2C16H12ClNO2