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Murcko scaffold

Ring system with 4 rings and 25 atoms

48 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
48
With full pages
3
Scaffold SMILES

c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 48 chemicals

4-(4-Chlorophenyl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine chemical structure, C20H19ClN4O, CAS 945746-69-0
4-(4-Chlorophenyl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine
CAS 945746-69-0C20H19ClN4O
4-(4-Aminophenyl)-N-(4-morpholinophenyl)pyrimidin-2-amine chemical structure, C20H21N5O, CAS 945747-04-6
4-(4-Aminophenyl)-N-(4-morpholinophenyl)pyrimidin-2-amine
CAS 945747-04-6C20H21N5O
4-[4-(Ethylamino)phenyl]-N-(4-{morpholin-4-yl}phenyl)pyrimidin-2-amine chemical structure, C22H25N5O, CAS 945747-05-7
4-[4-(Ethylamino)phenyl]-N-(4-{morpholin-4-yl}phenyl)pyrimidin-2-amine
CAS 945747-05-7C22H25N5O
[4-(4-Methoxy-phenyl)-pyrimidin-2-yl]-(4-morpholin-4-yl-phenyl)-amine chemical structure, C21H22N4O2, CAS 839726-96-4
[4-(4-Methoxy-phenyl)-pyrimidin-2-yl]-(4-morpholin-4-yl-phenyl)-amine
CAS 839726-96-4C21H22N4O2
n-Methyl-5-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzamide chemical structure, C23H26N6O4S, CAS 1056635-64-3
n-Methyl-5-(4-(4-(methylsulfonamido)phenyl)pyrimidin-2-ylamino)-2-morpholinobenzamide
CAS 1056635-64-3C23H26N6O4S
2-Methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzoic acid chemical structure, C23H24N4O4, CAS 1056635-38-1
2-Methoxy-4-(5-methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzoic acid
CAS 1056635-38-1C23H24N4O4
4-(5-Methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzenesulfonamide chemical structure, C21H23N5O3S, CAS 1056635-30-3
4-(5-Methyl-2-(4-morpholinophenylamino)pyrimidin-4-yl)benzenesulfonamide
CAS 1056635-30-3C21H23N5O3S
4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzamide chemical structure, C21H21N5O2, CAS 945749-05-3
4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzamide
CAS 945749-05-3C21H21N5O2
2-Chloro-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzonitrile chemical structure, C21H18ClN5O, CAS 1056635-13-2
2-Chloro-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzonitrile
CAS 1056635-13-2C21H18ClN5O
2-Methoxy-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzonitrile chemical structure, C22H21N5O2, CAS 1056635-08-5
2-Methoxy-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzonitrile
CAS 1056635-08-5C22H21N5O2
Ethyl 4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzoate chemical structure, C23H24N4O3, CAS 1056634-62-8
Ethyl 4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzoate
CAS 1056634-62-8C23H24N4O3
3-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzonitrile chemical structure, C21H19N5O, CAS 1056634-74-2
3-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzonitrile
CAS 1056634-74-2C21H19N5O
N-(2-Hydroxyethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide chemical structure, C23H25N5O3, CAS 1056634-71-9
N-(2-Hydroxyethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide
CAS 1056634-71-9C23H25N5O3
Momelotinib chemical structure, C23H22N6O2, CAS 1056634-68-4
Momelotinib
CAS 1056634-68-4C23H22N6O2
4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzonitrile chemical structure, C21H19N5O, CAS 945749-74-6
4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)benzonitrile
CAS 945749-74-6C21H19N5O
N-(4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)phenyl)methanesulfonamide chemical structure, C21H23N5O3S, CAS 945749-80-4
N-(4-(2-(4-Morpholinophenylamino)pyrimidin-4-yl)phenyl)methanesulfonamide
CAS 945749-80-4C21H23N5O3S
Momelotinib dihydrochloride chemical structure, C23H24Cl2N6O2, CAS 1380317-28-1
Momelotinib dihydrochloride
CAS 1380317-28-1C23H24Cl2N6O2
Methyl 4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzoate chemical structure, C22H22N4O3, CAS 945749-75-7
Methyl 4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzoate
CAS 945749-75-7C22H22N4O3
2-(Dimethylamino)-N-(4-(2-([4-{morpholin-4-yl}phenyl]amino)pyrimidin-4-yl)phenyl)acetamide chemical structure, C24H28N6O2, CAS 945748-40-3
2-(Dimethylamino)-N-(4-(2-([4-{morpholin-4-yl}phenyl]amino)pyrimidin-4-yl)phenyl)acetamide
CAS 945748-40-3C24H28N6O2
4-(2-((4-(4-Morpholinyl)phenyl)amino)-4-pyrimidinyl)benzoic acid chemical structure, C21H20N4O3, CAS 945749-71-3
4-(2-((4-(4-Morpholinyl)phenyl)amino)-4-pyrimidinyl)benzoic acid
CAS 945749-71-3C21H20N4O3
4-[3-(Methylsulfonyl)phenyl]-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine chemical structure, C21H22N4O3S, CAS 945748-86-7
4-[3-(Methylsulfonyl)phenyl]-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine
CAS 945748-86-7C21H22N4O3S
4-[4-(Methylsulfonyl)phenyl]-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine chemical structure, C21H22N4O3S, CAS 945748-84-5
4-[4-(Methylsulfonyl)phenyl]-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine
CAS 945748-84-5C21H22N4O3S
4-[4-(Methylamino)phenyl]-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine chemical structure, C21H23N5O, CAS 945747-68-2
4-[4-(Methylamino)phenyl]-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine
CAS 945747-68-2C21H23N5O
4-[4-(Methylthio)phenyl]-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine chemical structure, C21H22N4OS, CAS 945748-87-8
4-[4-(Methylthio)phenyl]-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine
CAS 945748-87-8C21H22N4OS