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Murcko scaffold

Ring system with 4 rings and 24 atoms

27 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 27
With full pages: 5

Scaffold SMILES

O=c1oc2c(CN3CCNCC3)cccc2cc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1oc2c(CN3CCNCC3)cccc2cc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

7-Hydroxy-3-(4-methoxyphenyl)-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one chemical structure, C22H24N2O4, CAS 824977-52-8

7-Hydroxy-3-(4-methoxyphenyl)-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one

CAS 824977-52-8C₂₂H₂₄N₂O₄

3-(4-Chlorophenyl)-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one chemical structure, C21H21ClN2O3, CAS 827002-89-1

3-(4-Chlorophenyl)-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one

CAS 827002-89-1C₂₁H₂₁ClN₂O₃

7-Hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-3-phenyl-2H-chromen-2-one chemical structure, C21H22N2O3, CAS 887218-32-8

7-Hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-3-phenyl-2H-chromen-2-one

CAS 887218-32-8C₂₁H₂₂N₂O₃

3-(2,4-Dimethoxyphenyl)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-4-methyl-2H-chromen-2-one chemical structure, C25H30N2O5, CAS 859668-80-7

3-(2,4-Dimethoxyphenyl)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-4-methyl-2H-chromen-2-one

CAS 859668-80-7C₂₅H₃₀N₂O₅

3-(2,4-Dimethoxyphenyl)-7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2H-chromen-2-one chemical structure, C24H28N2O6, CAS 859668-94-3

3-(2,4-Dimethoxyphenyl)-7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2H-chromen-2-one

CAS 859668-94-3C₂₄H₂₈N₂O₆

3-(2,5-Dimethoxyphenyl)-7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2H-chromen-2-one chemical structure, C24H28N2O6, CAS 859672-31-4

3-(2,5-Dimethoxyphenyl)-7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2H-chromen-2-one

CAS 859672-31-4C₂₄H₂₈N₂O₆

3-(2,5-Dimethoxyphenyl)-7-hydroxy-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one chemical structure, C23H26N2O5, CAS 864751-00-8

3-(2,5-Dimethoxyphenyl)-7-hydroxy-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one

CAS 864751-00-8C₂₃H₂₆N₂O₅

3-(2,5-Dimethoxyphenyl)-7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-4-methyl-2H-chromen-2-one chemical structure, C25H30N2O6, CAS 864751-88-2

3-(2,5-Dimethoxyphenyl)-7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-4-methyl-2H-chromen-2-one

CAS 864751-88-2C₂₅H₃₀N₂O₆

3-(2,4-Dimethoxyphenyl)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-2H-chromen-2-one chemical structure, C24H28N2O5, CAS 864752-34-1

3-(2,4-Dimethoxyphenyl)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-2H-chromen-2-one

CAS 864752-34-1C₂₄H₂₈N₂O₅

3-(2,5-Dimethoxyphenyl)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-4-methyl-2H-chromen-2-one chemical structure, C25H30N2O5, CAS 864752-63-6

3-(2,5-Dimethoxyphenyl)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-4-methyl-2H-chromen-2-one

CAS 864752-63-6C₂₅H₃₀N₂O₅

3-(2,4-Dimethoxyphenyl)-7-hydroxy-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one chemical structure, C23H26N2O5, CAS 864752-79-4

3-(2,4-Dimethoxyphenyl)-7-hydroxy-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one

CAS 864752-79-4C₂₃H₂₆N₂O₅

3-(2,4-Dimethoxyphenyl)-7-hydroxy-4-methyl-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one chemical structure, C24H28N2O5, CAS 864762-49-2

3-(2,4-Dimethoxyphenyl)-7-hydroxy-4-methyl-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one

CAS 864762-49-2C₂₄H₂₈N₂O₅

3-(2,5-Dimethoxyphenyl)-7-hydroxy-4-methyl-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one chemical structure, C24H28N2O5, CAS 864762-81-2

3-(2,5-Dimethoxyphenyl)-7-hydroxy-4-methyl-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one

CAS 864762-81-2C₂₄H₂₈N₂O₅

7-Hydroxy-4-methyl-8-[(4-methylpiperazin-1-yl)methyl]-3-phenyl-2H-chromen-2-one chemical structure, C22H24N2O3, CAS 869340-69-2

7-Hydroxy-4-methyl-8-[(4-methylpiperazin-1-yl)methyl]-3-phenyl-2H-chromen-2-one

CAS 869340-69-2C₂₂H₂₄N₂O₃

3-(4-Chlorophenyl)-7-hydroxy-4-methyl-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one chemical structure, C22H23ClN2O3, CAS 869340-70-5

3-(4-Chlorophenyl)-7-hydroxy-4-methyl-8-((4-methylpiperazin-1-yl)methyl)-2H-chromen-2-one

CAS 869340-70-5C₂₂H₂₃ClN₂O₃

7-Hydroxy-3-(4-methoxyphenyl)-4-methyl-8-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one chemical structure, C23H26N2O4, CAS 869340-71-6

7-Hydroxy-3-(4-methoxyphenyl)-4-methyl-8-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one

CAS 869340-71-6C₂₃H₂₆N₂O₄

3-(3,4-Dimethoxyphenyl)-7-hydroxy-4-methyl-8-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one chemical structure, C24H28N2O5, CAS 869340-73-8

3-(3,4-Dimethoxyphenyl)-7-hydroxy-4-methyl-8-[(4-methylpiperazin-1-yl)methyl]-2H-chromen-2-one

CAS 869340-73-8C₂₄H₂₈N₂O₅

7-Hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-phenyl-2H-chromen-2-one chemical structure, C22H24N2O4, CAS 887218-45-3

7-Hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-phenyl-2H-chromen-2-one

CAS 887218-45-3C₂₂H₂₄N₂O₄

7-Hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-4-methyl-3-phenyl-2H-chromen-2-one chemical structure, C23H26N2O4, CAS 869340-74-9

7-Hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-4-methyl-3-phenyl-2H-chromen-2-one

CAS 869340-74-9C₂₃H₂₆N₂O₄

3-(4-Chlorophenyl)-7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2H-chromen-2-one chemical structure, C22H23ClN2O4, CAS 869340-75-0

3-(4-Chlorophenyl)-7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2H-chromen-2-one

CAS 869340-75-0C₂₂H₂₃ClN₂O₄

8-[(4-Ethylpiperazin-1-yl)methyl]-7-hydroxy-3-phenyl-2H-chromen-2-one chemical structure, C22H24N2O3, CAS 887218-70-4

8-[(4-Ethylpiperazin-1-yl)methyl]-7-hydroxy-3-phenyl-2H-chromen-2-one

CAS 887218-70-4C₂₂H₂₄N₂O₃

8-[(4-Ethylpiperazin-1-yl)methyl]-7-hydroxy-4-methyl-3-phenyl-2H-chromen-2-one chemical structure, C23H26N2O3, CAS 869340-84-1

8-[(4-Ethylpiperazin-1-yl)methyl]-7-hydroxy-4-methyl-3-phenyl-2H-chromen-2-one

CAS 869340-84-1C₂₃H₂₆N₂O₃

8-[(4-Ethylpiperazin-1-yl)methyl]-7-hydroxy-3-(4-methoxyphenyl)-2H-chromen-2-one chemical structure, C23H26N2O4, CAS 869340-87-4

8-[(4-Ethylpiperazin-1-yl)methyl]-7-hydroxy-3-(4-methoxyphenyl)-2H-chromen-2-one

CAS 869340-87-4C₂₃H₂₆N₂O₄

3-(4-Chlorophenyl)-7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-methyl-2H-chromen-2-one chemical structure, C23H25ClN2O4, CAS 869340-76-1

3-(4-Chlorophenyl)-7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-4-methyl-2H-chromen-2-one

CAS 869340-76-1C₂₃H₂₅ClN₂O₄