Free for buyers, contact details stay privateFree for buyers. Your contact details stay private until you accept a quote.

Sign in Join free

Murcko scaffold

Ring system with 4 rings and 24 atoms

49 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 24
Chemicals: 49
With full pages: 12

Scaffold SMILES

O=c1c(-c2ccccc2)coc2c(CN3CCNCC3)cccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1c(-c2ccccc2)coc2c(CN3CCNCC3)cccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 49 chemicals

Ethyl 7-hydroxy-3-(2-methoxyphenyl)-8-[(4-methylpiperazin-1-yl)methyl]-4-oxo-4H-chromene-2-carboxylate chemical structure, C25H28N2O6, CAS 637746-84-0

Ethyl 7-hydroxy-3-(2-methoxyphenyl)-8-[(4-methylpiperazin-1-yl)methyl]-4-oxo-4H-chromene-2-carboxylate

CAS 637746-84-0C₂₅H₂₈N₂O₆

7-Hydroxy-3-(4-methoxyphenyl)-2-methyl-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one chemical structure, C23H26N2O4, CAS 637747-33-2

7-Hydroxy-3-(4-methoxyphenyl)-2-methyl-8-((4-methylpiperazin-1-yl)methyl)-4H-chromen-4-one

CAS 637747-33-2C₂₃H₂₆N₂O₄

7-Hydroxy-3-(2-methoxyphenyl)-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one chemical structure, C22H24N2O4, CAS 303121-36-0

7-Hydroxy-3-(2-methoxyphenyl)-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one

CAS 303121-36-0C₂₂H₂₄N₂O₄

3-(3,4-Dimethoxyphenyl)-8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C25H27F3N2O5, CAS 307535-09-7

3-(3,4-Dimethoxyphenyl)-8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

CAS 307535-09-7C₂₅H₂₇F₃N₂O₅

7-Hydroxy-3-(2-methoxyphenyl)-8-((4-methylpiperazin-1-yl)methyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C23H23F3N2O4, CAS 303119-47-3

7-Hydroxy-3-(2-methoxyphenyl)-8-((4-methylpiperazin-1-yl)methyl)-2-(trifluoromethyl)-4H-chromen-4-one

CAS 303119-47-3C₂₃H₂₃F₃N₂O₄

8-[(4-Ethylpiperazin-1-yl)methyl]-7-hydroxy-3-(2-methoxyphenyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C24H25F3N2O4, CAS 303122-14-7

8-[(4-Ethylpiperazin-1-yl)methyl]-7-hydroxy-3-(2-methoxyphenyl)-2-(trifluoromethyl)-4H-chromen-4-one

CAS 303122-14-7C₂₄H₂₅F₃N₂O₄

3-(4-Chlorophenyl)-7-hydroxy-8-[(4-methylpiperazinyl)methyl]chromen-4-one chemical structure, C21H21ClN2O3, CAS 302575-41-3

3-(4-Chlorophenyl)-7-hydroxy-8-[(4-methylpiperazinyl)methyl]chromen-4-one

CAS 302575-41-3C₂₁H₂₁ClN₂O₃

3-(2,4-Dichlorophenyl)-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one chemical structure, C21H20Cl2N2O3, CAS 302575-47-9

3-(2,4-Dichlorophenyl)-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one

CAS 302575-47-9C₂₁H₂₀Cl₂N₂O₃

3-(3,4-Dimethoxyphenyl)-8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-2-methyl-4H-chromen-4-one chemical structure, C25H30N2O5, CAS 846580-49-2

3-(3,4-Dimethoxyphenyl)-8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-2-methyl-4H-chromen-4-one

CAS 846580-49-2C₂₅H₃₀N₂O₅

7-Hydroxy-3-(4-methoxyphenyl)-8-[(4-methylpiperazin-1-yl)methyl]-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C23H23F3N2O4, CAS 847036-36-6

7-Hydroxy-3-(4-methoxyphenyl)-8-[(4-methylpiperazin-1-yl)methyl]-2-(trifluoromethyl)-4H-chromen-4-one

CAS 847036-36-6C₂₃H₂₃F₃N₂O₄

3-(3,4-Dimethoxyphenyl)-7-hydroxy-8-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]-2-methylchromen-4-one chemical structure, C25H30N2O6, CAS 637753-52-7

3-(3,4-Dimethoxyphenyl)-7-hydroxy-8-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]-2-methylchromen-4-one

CAS 637753-52-7C₂₅H₃₀N₂O₆

7-Hydroxy-8-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-3-(2-methoxyphenyl)-2-methyl-1-benzopyran-4-one chemical structure, C24H28N2O5, CAS 637753-64-1

7-Hydroxy-8-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-3-(2-methoxyphenyl)-2-methyl-1-benzopyran-4-one

CAS 637753-64-1C₂₄H₂₈N₂O₅

7-Hydroxy-3-(2-methoxyphenyl)-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one chemical structure, C23H26N2O4, CAS 637747-21-8

7-Hydroxy-3-(2-methoxyphenyl)-2-methyl-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one

CAS 637747-21-8C₂₃H₂₆N₂O₄

8-(4-Ethyl-piperazin-1-ylmethyl)-7-hydroxy-3-(2-methoxy-phenyl)-chromen-4-one chemical structure, C23H26N2O4, CAS 303122-05-6

8-(4-Ethyl-piperazin-1-ylmethyl)-7-hydroxy-3-(2-methoxy-phenyl)-chromen-4-one

CAS 303122-05-6C₂₃H₂₆N₂O₄

3-(3,4-Dimethoxyphenyl)-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C24H25F3N2O5, CAS 307535-08-6

3-(3,4-Dimethoxyphenyl)-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-2-(trifluoromethyl)-4H-chromen-4-one

CAS 307535-08-6C₂₄H₂₅F₃N₂O₅

3-(2-Chlorophenyl)-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one chemical structure, C21H21ClN2O3, CAS 333747-51-6

3-(2-Chlorophenyl)-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-4H-chromen-4-one

CAS 333747-51-6C₂₁H₂₁ClN₂O₃

3-(4-Chlorophenyl)-8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C23H22ClF3N2O3, CAS 431067-09-3

3-(4-Chlorophenyl)-8-[(4-ethylpiperazin-1-yl)methyl]-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one

CAS 431067-09-3C₂₃H₂₂ClF₃N₂O₃

7-Hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(4-methoxyphenyl)-4H-chromen-4-one chemical structure, C23H26N2O5, CAS 637753-55-0

7-Hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(4-methoxyphenyl)-4H-chromen-4-one

CAS 637753-55-0C₂₃H₂₆N₂O₅

3-(4-Chlorophenyl)-7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2-methyl-4H-chromen-4-one chemical structure, C23H25ClN2O4, CAS 847272-24-6

3-(4-Chlorophenyl)-7-hydroxy-8-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-2-methyl-4H-chromen-4-one

CAS 847272-24-6C₂₃H₂₅ClN₂O₄

8-((4-Ethylpiperazin-1-yl)methyl)-7-hydroxy-2-methyl-3-phenyl-4H-chromen-4-one chemical structure, C23H26N2O3, CAS 847379-91-3

8-((4-Ethylpiperazin-1-yl)methyl)-7-hydroxy-2-methyl-3-phenyl-4H-chromen-4-one

CAS 847379-91-3C₂₃H₂₆N₂O₃

3-(4-Bromophenyl)-7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-methyl-4H-chromen-4-one chemical structure, C23H25BrN2O4, CAS 847176-88-9

3-(4-Bromophenyl)-7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-methyl-4H-chromen-4-one

CAS 847176-88-9C₂₃H₂₅BrN₂O₄

3-(4-Chlorophenyl)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-4H-chromen-4-one chemical structure, C22H23ClN2O3, CAS 847247-24-9

3-(4-Chlorophenyl)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-4H-chromen-4-one

CAS 847247-24-9C₂₂H₂₃ClN₂O₃

3-(4-Bromophenyl)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-2-methyl-4H-chromen-4-one chemical structure, C23H25BrN2O3, CAS 848059-73-4

3-(4-Bromophenyl)-8-((4-ethylpiperazin-1-yl)methyl)-7-hydroxy-2-methyl-4H-chromen-4-one

CAS 848059-73-4C₂₃H₂₅BrN₂O₃

3-(4-Chlorophenyl)-7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C23H22ClF3N2O4, CAS 846062-69-9

3-(4-Chlorophenyl)-7-hydroxy-8-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-2-(trifluoromethyl)-4H-chromen-4-one

CAS 846062-69-9C₂₃H₂₂ClF₃N₂O₄