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Murcko scaffold

Ring system with 4 rings and 24 atoms

58 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
58
With full pages
24
Scaffold SMILES

O=c1c(-c2ccccc2)coc2c(CN3CCCCC3)cccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(-c2ccccc2)coc2c(CN3CCCCC3)cccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 58 chemicals

6-Ethyl-3-(4-fluorophenyl)-7-hydroxy-2-methyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C24H26FNO3, CAS 328019-76-7
6-Ethyl-3-(4-fluorophenyl)-7-hydroxy-2-methyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
CAS 328019-76-7C24H26FNO3
6-Ethyl-3-(4-fluorophenyl)-7-hydroxy-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C24H23F4NO3, CAS 328019-77-8
6-Ethyl-3-(4-fluorophenyl)-7-hydroxy-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 328019-77-8C24H23F4NO3
3-(3,4-Dimethoxyphenyl)-7-hydroxy-2-methyl-8-[(2-methyl-1-piperidinyl)methyl]-1-benzopyran-4-one chemical structure, C25H29NO5, CAS 610759-94-9
3-(3,4-Dimethoxyphenyl)-7-hydroxy-2-methyl-8-[(2-methyl-1-piperidinyl)methyl]-1-benzopyran-4-one
CAS 610759-94-9C25H29NO5
7-Hydroxy-3-(2-methoxyphenyl)-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C23H22F3NO4, CAS 303119-40-6
7-Hydroxy-3-(2-methoxyphenyl)-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 303119-40-6C23H22F3NO4
3-(4-Chlorophenyl)-7-hydroxy-8-(piperidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C21H20ClNO3, CAS 302575-35-5
3-(4-Chlorophenyl)-7-hydroxy-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
CAS 302575-35-5C21H20ClNO3
3-(4-Chlorophenyl)-8-[(2-ethylpiperidin-1-yl)methyl]-7-hydroxychromen-4-one chemical structure, C23H24ClNO3, CAS 5941-59-3
3-(4-Chlorophenyl)-8-[(2-ethylpiperidin-1-yl)methyl]-7-hydroxychromen-4-one
CAS 5941-59-3C23H24ClNO3
8-(2-Ethyl-piperidin-1-ylmethyl)-7-hydroxy-3-phenyl-chromen-4-one chemical structure, C23H25NO3, CAS 5943-68-0
8-(2-Ethyl-piperidin-1-ylmethyl)-7-hydroxy-3-phenyl-chromen-4-one
CAS 5943-68-0C23H25NO3
7-Hydroxy-3-(2-methoxyphenyl)-8-[(4-methyl-1-piperidinyl)methyl]-1-benzopyran-4-one chemical structure, C23H25NO4, CAS 303121-22-4
7-Hydroxy-3-(2-methoxyphenyl)-8-[(4-methyl-1-piperidinyl)methyl]-1-benzopyran-4-one
CAS 303121-22-4C23H25NO4
3-(3,4-Dimethoxyphenyl)-8-[(2-ethylpiperidin-1-yl)methyl]-7-hydroxy-2-(trifluoromethyl)chromen-4-one chemical structure, C26H28F3NO5, CAS 307535-07-5
3-(3,4-Dimethoxyphenyl)-8-[(2-ethylpiperidin-1-yl)methyl]-7-hydroxy-2-(trifluoromethyl)chromen-4-one
CAS 307535-07-5C26H28F3NO5
Isoflavone, 7-hydroxy-2-methyl-8-(piperidinomethyl)-, hydrochloride chemical structure, C22H24ClNO3, CAS 67292-74-4
Isoflavone, 7-hydroxy-2-methyl-8-(piperidinomethyl)-, hydrochloride
CAS 67292-74-4C22H24ClNO3
7-Hydroxy-2-methyl-3-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C22H23NO3, CAS 122766-05-6
7-Hydroxy-2-methyl-3-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
CAS 122766-05-6C22H23NO3
Isoflavone, 7-hydroxy-8-(piperidinomethyl)-, hydrochloride chemical structure, C21H22ClNO3, CAS 67292-76-6
Isoflavone, 7-hydroxy-8-(piperidinomethyl)-, hydrochloride
CAS 67292-76-6C21H22ClNO3
7-Hydroxy-3-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C21H21NO3, CAS 111978-65-5
7-Hydroxy-3-phenyl-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
CAS 111978-65-5C21H21NO3
7-Hydroxy-3-(2-methoxyphenyl)-8-(piperidin-1-ylmethyl)-4H-chromen-4-one chemical structure, C22H23NO4, CAS 303121-24-6
7-Hydroxy-3-(2-methoxyphenyl)-8-(piperidin-1-ylmethyl)-4H-chromen-4-one
CAS 303121-24-6C22H23NO4
7-Hydroxy-3-phenyl-8-(1-piperidinylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C22H20F3NO3, CAS 307507-26-2
7-Hydroxy-3-phenyl-8-(1-piperidinylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 307507-26-2C22H20F3NO3
7-Hydroxy-3-(4-methoxyphenyl)-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C23H22F3NO4, CAS 637751-83-8
7-Hydroxy-3-(4-methoxyphenyl)-8-(piperidin-1-ylmethyl)-2-(trifluoromethyl)-4H-chromen-4-one
CAS 637751-83-8C23H22F3NO4
7-Hydroxy-3-(2-methoxy-phenyl)-8-(2-methyl-piperidin-1-ylmethyl)-chromen-4-one chemical structure, C23H25NO4, CAS 303121-38-2
7-Hydroxy-3-(2-methoxy-phenyl)-8-(2-methyl-piperidin-1-ylmethyl)-chromen-4-one
CAS 303121-38-2C23H25NO4
8-[(2-Ethyl-1-piperidinyl)methyl]-7-hydroxy-3-phenyl-2-(trifluoromethyl)-4H-chromen-4-one chemical structure, C24H24F3NO3, CAS 442651-54-9
8-[(2-Ethyl-1-piperidinyl)methyl]-7-hydroxy-3-phenyl-2-(trifluoromethyl)-4H-chromen-4-one
CAS 442651-54-9C24H24F3NO3
7-Hydroxy-8-((2-methylpiperidin-1-yl)methyl)-3-phenyl-4H-chromen-4-one chemical structure, C22H23NO3, CAS 459152-47-7
7-Hydroxy-8-((2-methylpiperidin-1-yl)methyl)-3-phenyl-4H-chromen-4-one
CAS 459152-47-7C22H23NO3
7-Hydroxy-8-[(2-methylpiperidin-1-yl)methyl]-3-phenyl-2-(trifluoromethyl)chromen-4-one chemical structure, C23H22F3NO3, CAS 385418-85-9
7-Hydroxy-8-[(2-methylpiperidin-1-yl)methyl]-3-phenyl-2-(trifluoromethyl)chromen-4-one
CAS 385418-85-9C23H22F3NO3
7-Hydroxy-8-[(3-methylpiperidin-1-yl)methyl]-3-phenylchromen-4-one chemical structure, C22H23NO3, CAS 685135-08-4
7-Hydroxy-8-[(3-methylpiperidin-1-yl)methyl]-3-phenylchromen-4-one
CAS 685135-08-4C22H23NO3
3-(4-Chlorophenyl)-7-hydroxy-8-[(3-methylpiperidin-1-yl)methyl]-4H-chromen-4-one chemical structure, C22H22ClNO3, CAS 685135-09-5
3-(4-Chlorophenyl)-7-hydroxy-8-[(3-methylpiperidin-1-yl)methyl]-4H-chromen-4-one
CAS 685135-09-5C22H22ClNO3
Ethyl 3-(3,4-dimethoxyphenyl)-7-hydroxy-8-[(2-methylpiperidin-1-yl)methyl]-4-oxo-4H-chromene-2-carboxylate chemical structure, C27H31NO7, CAS 610759-93-8
Ethyl 3-(3,4-dimethoxyphenyl)-7-hydroxy-8-[(2-methylpiperidin-1-yl)methyl]-4-oxo-4H-chromene-2-carboxylate
CAS 610759-93-8C27H31NO7
3-(4-Bromophenyl)-7-hydroxy-8-((2-methylpiperidin-1-yl)methyl)-4H-chromen-4-one chemical structure, C22H22BrNO3, CAS 610759-69-8
3-(4-Bromophenyl)-7-hydroxy-8-((2-methylpiperidin-1-yl)methyl)-4H-chromen-4-one
CAS 610759-69-8C22H22BrNO3