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Murcko scaffold

6-Phenyl-2-thiouracil scaffold

80 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
80
With full pages
10
Scaffold SMILES

O=c1cc(-c2ccccc2)[nH]c(=S)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 6-Phenyl-2-thiouracil page
Murcko scaffold O=c1cc(-c2ccccc2)[nH]c(=S)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 80 chemicals

4-(4-Fluorophenyl)-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile chemical structure, C11H6FN3OS, CAS 131364-75-5
4-(4-Fluorophenyl)-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile
CAS 131364-75-5C11H6FN3OS
4-Oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile chemical structure, C11H7N3OS, CAS 70638-52-7
4-Oxo-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
CAS 70638-52-7C11H7N3OS
6-(4-Isopropylphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile chemical structure, C14H13N3OS, CAS 339235-45-9
6-(4-Isopropylphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
CAS 339235-45-9C14H13N3OS
6-Phenyl-2-thiouracil chemical structure, C10H8N2OS, CAS 36822-11-4
6-Phenyl-2-thiouracil
CAS 36822-11-4C10H8N2OS
6-(4-Methylphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile chemical structure, C12H9N3OS, CAS 70638-53-8
6-(4-Methylphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
CAS 70638-53-8C12H9N3OS
4-(4-Chlorophenyl)-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile chemical structure, C11H6ClN3OS, CAS 70638-56-1
4-(4-Chlorophenyl)-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile
CAS 70638-56-1C11H6ClN3OS
6-(4-Ethoxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile chemical structure, C13H11N3O2S, CAS 331003-64-6
6-(4-Ethoxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
CAS 331003-64-6C13H11N3O2S
4-[4-(Dimethylamino)phenyl]-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile chemical structure, C13H12N4OS, CAS 5185-15-9
4-[4-(Dimethylamino)phenyl]-6-hydroxy-2-sulfanylpyrimidine-5-carbonitrile
CAS 5185-15-9C13H12N4OS
6-(4-Methoxyphenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one chemical structure, C11H10N2O2S, CAS 33166-87-9
6-(4-Methoxyphenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
CAS 33166-87-9C11H10N2O2S
6-(2-Hydroxyphenyl)-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one chemical structure, C10H8N2O2S, CAS 55982-10-0
6-(2-Hydroxyphenyl)-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
CAS 55982-10-0C10H8N2O2S
1,2,3,4-Tetrahydro-6-(4-methoxyphenyl)-4-oxo-2-thioxo-5-pyrimidinecarbonitrile chemical structure, C12H9N3O2S, CAS 70638-54-9
1,2,3,4-Tetrahydro-6-(4-methoxyphenyl)-4-oxo-2-thioxo-5-pyrimidinecarbonitrile
CAS 70638-54-9C12H9N3O2S
6-(2-Methoxyphenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile chemical structure, C12H9N3O2S, CAS 571155-43-6
6-(2-Methoxyphenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile
CAS 571155-43-6C12H9N3O2S
6-(4-Hydroxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone chemical structure, C10H8N2O2S, CAS 375834-47-2
6-(4-Hydroxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone
CAS 375834-47-2C10H8N2O2S
5-(2-Hydroxyethyl)-2-sulfanylidene-6-(3,4,5-trimethoxyphenyl)-2,3-dihydropyrimidin-4(1H)-one chemical structure, C15H18N2O5S, CAS 21585-22-8
5-(2-Hydroxyethyl)-2-sulfanylidene-6-(3,4,5-trimethoxyphenyl)-2,3-dihydropyrimidin-4(1H)-one
CAS 21585-22-8C15H18N2O5S
5-(2-Hydroxyethyl)-6-(4-methylphenyl)-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C13H14N2O2S, CAS 21585-15-9
5-(2-Hydroxyethyl)-6-(4-methylphenyl)-2-sulfanylidene-1H-pyrimidin-4-one
CAS 21585-15-9C13H14N2O2S
5-(2-Hydroxyethyl)-6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C12H12N2O2S, CAS 21585-17-1
5-(2-Hydroxyethyl)-6-phenyl-2-sulfanylidene-1H-pyrimidin-4-one
CAS 21585-17-1C12H12N2O2S
5-(2-Hydroxyethyl)-6-(4-methoxyphenyl)-2-sulfanylidene-1H-pyrimidin-4-one chemical structure, C13H14N2O3S, CAS 21585-19-3
5-(2-Hydroxyethyl)-6-(4-methoxyphenyl)-2-sulfanylidene-1H-pyrimidin-4-one
CAS 21585-19-3C13H14N2O3S
6-(4-Methoxy-3-propoxyphenyl)-4-oxo-2-sulfanylidene-1H-pyrimidine-5-carbonitrile chemical structure, C15H15N3O3S, CAS 857493-67-5
6-(4-Methoxy-3-propoxyphenyl)-4-oxo-2-sulfanylidene-1H-pyrimidine-5-carbonitrile
CAS 857493-67-5C15H15N3O3S
2-[4-(5-Cyano-4-oxo-2-sulfanylidene-1H-pyrimidin-6-yl)phenoxy]-N,N-diethylacetamide chemical structure, C17H18N4O3S, CAS 857493-70-0
2-[4-(5-Cyano-4-oxo-2-sulfanylidene-1H-pyrimidin-6-yl)phenoxy]-N,N-diethylacetamide
CAS 857493-70-0C17H18N4O3S
4-(4-tert-Butylphenyl)-6-oxo-2-sulfanyl-1,6-dihydro-5-pyrimidinecarbonitrile chemical structure, C15H15N3OS, CAS 857493-71-1
4-(4-tert-Butylphenyl)-6-oxo-2-sulfanyl-1,6-dihydro-5-pyrimidinecarbonitrile
CAS 857493-71-1C15H15N3OS
6-(3-Methoxy-phenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile chemical structure, C12H9N3O2S, CAS 131890-31-8
6-(3-Methoxy-phenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile
CAS 131890-31-8C12H9N3O2S
6-(3-Fluorophenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one chemical structure, C10H7FN2OS, CAS 33297-99-3
6-(3-Fluorophenyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
CAS 33297-99-3C10H7FN2OS
6-(4-Fluorophenyl)-2-mercaptopyrimidin-4-ol chemical structure, C10H7FN2OS, CAS 33166-85-7
6-(4-Fluorophenyl)-2-mercaptopyrimidin-4-ol
CAS 33166-85-7C10H7FN2OS
5-Chloro-6-(2-hydroxyphenyl)-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one chemical structure, C10H7ClN2O2S, CAS 89073-93-8
5-Chloro-6-(2-hydroxyphenyl)-2-sulfanylidene-2,3-dihydropyrimidin-4(1H)-one
CAS 89073-93-8C10H7ClN2O2S