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Murcko scaffold

2-Phenyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione scaffold

50 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
14
Chemicals
50
With full pages
13
Scaffold SMILES

O=c1cnn(-c2ccccc2)c(=O)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Phenyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione page
Murcko scaffold O=c1cnn(-c2ccccc2)c(=O)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

2-(3-Methylphenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxylic acid chemical structure, C11H9N3O4, CAS 68321-62-0
2-(3-Methylphenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxylic acid
CAS 68321-62-0C11H9N3O4
6-Acetyl-2-(3-methoxyphenyl)-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C12H11N3O4, CAS 338400-96-7
6-Acetyl-2-(3-methoxyphenyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS 338400-96-7C12H11N3O4
6-(3-(Dimethylamino)acryloyl)-2-(3-methoxyphenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C16H18N4O4, CAS 338401-05-1
6-(3-(Dimethylamino)acryloyl)-2-(3-methoxyphenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione
CAS 338401-05-1C16H18N4O4
6-Acetyl-2-(2,4-difluorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C11H7F2N3O3, CAS 477854-19-6
6-Acetyl-2-(2,4-difluorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS 477854-19-6C11H7F2N3O3
6-Acetyl-2-(4-chlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C11H8ClN3O3, CAS 477854-20-9
6-Acetyl-2-(4-chlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS 477854-20-9C11H8ClN3O3
6-Acetyl-2-(2,4-difluorophenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C12H9F2N3O3, CAS 477854-21-0
6-Acetyl-2-(2,4-difluorophenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione
CAS 477854-21-0C12H9F2N3O3
6-(2-Bromoacetyl)-2-(2,4-difluorophenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C12H8BrF2N3O3, CAS 477854-23-2
6-(2-Bromoacetyl)-2-(2,4-difluorophenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione
CAS 477854-23-2C12H8BrF2N3O3
2-(4-Chlorophenyl)-6-[3-(dimethylamino)acryloyl]-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C15H15ClN4O3, CAS 1164529-87-6
2-(4-Chlorophenyl)-6-[3-(dimethylamino)acryloyl]-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione
CAS 1164529-87-6C15H15ClN4O3
6-Acetyl-2-(3,5-dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C11H7Cl2N3O3, CAS 477854-25-4
6-Acetyl-2-(3,5-dichlorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS 477854-25-4C11H7Cl2N3O3
2-(2,4-Difluorophenyl)-6-(3-(dimethylamino)acryloyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C15H14F2N4O3, CAS 1164548-78-0
2-(2,4-Difluorophenyl)-6-(3-(dimethylamino)acryloyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione
CAS 1164548-78-0C15H14F2N4O3
6-Acetyl-2-(4-methoxyphenyl)-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C12H11N3O4, CAS 477854-31-2
6-Acetyl-2-(4-methoxyphenyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS 477854-31-2C12H11N3O4
6-Acetyl-2-(3,5-dichlorophenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C12H9Cl2N3O3, CAS 477854-32-3
6-Acetyl-2-(3,5-dichlorophenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione
CAS 477854-32-3C12H9Cl2N3O3
6-Acetyl-2-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C12H8F3N3O3, CAS 477854-36-7
6-Acetyl-2-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione
CAS 477854-36-7C12H8F3N3O3
6-(3-(Dimethylamino)acryloyl)-2-(3,5-dimethylphenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C17H20N4O3, CAS 1164529-91-2
6-(3-(Dimethylamino)acryloyl)-2-(3,5-dimethylphenyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione
CAS 1164529-91-2C17H20N4O3
6-Acetyl-2-(4-(trifluoromethyl)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C12H8F3N3O3, CAS 478042-74-9
6-Acetyl-2-(4-(trifluoromethyl)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS 478042-74-9C12H8F3N3O3
6-[3-(Dimethylamino)acryloyl]-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C16H15F3N4O3
6-[3-(Dimethylamino)acryloyl]-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione
C16H15F3N4O3
6-[(E)-3-(Dimethylamino)prop-2-enoyl]-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,4-triazine-3,5-dione chemical structure, C16H15F3N4O3
6-[(E)-3-(Dimethylamino)prop-2-enoyl]-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,2,4-triazine-3,5-dione
C16H15F3N4O3
6-Acetyl-2-(3,5-dimethylphenyl)-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C13H13N3O3, CAS 478048-44-1
6-Acetyl-2-(3,5-dimethylphenyl)-1,2,4-triazine-3,5(2H,4H)-dione
CAS 478048-44-1C13H13N3O3
2-(4-Fluorophenyl)-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile chemical structure, C11H7FN4O2, CAS 478048-47-4
2-(4-Fluorophenyl)-4-methyl-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
CAS 478048-47-4C11H7FN4O2
6-[3-(Dimethylamino)acryloyl]-4-methyl-2-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione chemical structure, C16H15F3N4O3, CAS 1164482-50-1
6-[3-(Dimethylamino)acryloyl]-4-methyl-2-[3-(trifluoromethyl)phenyl]-1,2,4-triazine-3,5(2H,4H)-dione
CAS 1164482-50-1C16H15F3N4O3
2-(3-Methoxyphenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile chemical structure, C11H8N4O3, CAS 338982-38-0
2-(3-Methoxyphenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
CAS 338982-38-0C11H8N4O3
2-(3-Chlorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile chemical structure, C10H5ClN4O2, CAS 338982-39-1
2-(3-Chlorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
CAS 338982-39-1C10H5ClN4O2
2-(4-Chlorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile chemical structure, C10H5ClN4O2, CAS 20932-04-1
2-(4-Chlorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
CAS 20932-04-1C10H5ClN4O2
2-(2,6-Difluorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile chemical structure, C10H4F2N4O2, CAS 338982-41-5
2-(2,6-Difluorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile
CAS 338982-41-5C10H4F2N4O2