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Murcko scaffold

Ring system with 3 rings and 22 atoms

91 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
91
With full pages
0
Scaffold SMILES

O=c1c(NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1c(NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 91 chemicals

N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzenesulfonamide chemical structure, C17H17N3O3S, CAS 4392-43-2
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzenesulfonamide
CAS 4392-43-2C17H17N3O3S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2,4,6-trimethylbenzenesulfonamide chemical structure, C20H23N3O3S, CAS 301228-94-4
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2,4,6-trimethylbenzenesulfonamide
CAS 301228-94-4C20H23N3O3S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methoxy-3-methylbenzenesulfonamide chemical structure, C19H21N3O4S, CAS 723738-32-7
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methoxy-3-methylbenzenesulfonamide
CAS 723738-32-7C19H21N3O4S
2,3-Dichloro-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methoxybenzenesulfonamide chemical structure, C18H17Cl2N3O4S, CAS 680592-86-3
2,3-Dichloro-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methoxybenzenesulfonamide
CAS 680592-86-3C18H17Cl2N3O4S
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-4-iodobenzenesulfonamide chemical structure, C17H16IN3O3S, CAS 723743-60-0
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-4-iodobenzenesulfonamide
CAS 723743-60-0C17H16IN3O3S
2-Bromo-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4,5-dimethoxybenzenesulfonamide chemical structure, C19H20BrN3O5S, CAS 540513-97-1
2-Bromo-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4,5-dimethoxybenzenesulfonamide
CAS 540513-97-1C19H20BrN3O5S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3,4-dimethoxybenzenesulfonamide chemical structure, C19H21N3O5S, CAS 403670-28-0
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3,4-dimethoxybenzenesulfonamide
CAS 403670-28-0C19H21N3O5S
4-Amino-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzenesulfonamide chemical structure, C17H18N4O3S, CAS 71119-16-9
4-Amino-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzenesulfonamide
CAS 71119-16-9C17H18N4O3S
4-tert-Butyl-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzenesulfonamide chemical structure, C21H25N3O3S, CAS 305373-53-9
4-tert-Butyl-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzenesulfonamide
CAS 305373-53-9C21H25N3O3S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-fluorobenzenesulfonamide chemical structure, C17H16FN3O3S, CAS 311329-11-0
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-fluorobenzenesulfonamide
CAS 311329-11-0C17H16FN3O3S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methoxybenzenesulfonamide chemical structure, C18H19N3O4S, CAS 331271-19-3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methoxybenzenesulfonamide
CAS 331271-19-3C18H19N3O4S
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2,5-dimethylbenzenesulfonamide chemical structure, C19H21N3O3S, CAS 439132-46-4
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2,5-dimethylbenzenesulfonamide
CAS 439132-46-4C19H21N3O3S
4-Bromo-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzenesulfonamide chemical structure, C17H16BrN3O3S, CAS 301337-57-5
4-Bromo-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzenesulfonamide
CAS 301337-57-5C17H16BrN3O3S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2,5-dimethoxybenzenesulfonamide chemical structure, C19H21N3O5S, CAS 725215-60-1
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2,5-dimethoxybenzenesulfonamide
CAS 725215-60-1C19H21N3O5S
4-(((4-Chlorophenyl)sulfonyl)amino)-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one chemical structure, C17H16ClN3O3S, CAS 301314-62-5
4-(((4-Chlorophenyl)sulfonyl)amino)-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
CAS 301314-62-5C17H16ClN3O3S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide chemical structure, C18H19N3O3S, CAS 78439-89-1
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-methylbenzenesulfonamide
CAS 78439-89-1C18H19N3O3S
2,3-Dimethyl-4-(((4-nitrophenyl)sulfonyl)amino)-1-phenyl-3-pyrazolin-5-one chemical structure, C17H16N4O5S, CAS 301332-17-2
2,3-Dimethyl-4-(((4-nitrophenyl)sulfonyl)amino)-1-phenyl-3-pyrazolin-5-one
CAS 301332-17-2C17H16N4O5S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-nitrobenzene-1-sulfonamide chemical structure, C17H16N4O5S, CAS 304687-54-5
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-nitrobenzene-1-sulfonamide
CAS 304687-54-5C17H16N4O5S
N-{4-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)sulfamoyl]phenyl}acetamide chemical structure, C19H20N4O4S, CAS 32061-15-7
N-{4-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)sulfamoyl]phenyl}acetamide
CAS 32061-15-7C19H20N4O4S
5-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylsulfamoyl)-2-methoxy-benzoic acid chemical structure, C19H19N3O6S, CAS 326907-75-9
5-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylsulfamoyl)-2-methoxy-benzoic acid
CAS 326907-75-9C19H19N3O6S
3-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)sulfamoyl]benzoic acid chemical structure, C18H17N3O5S, CAS 307511-52-0
3-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)sulfamoyl]benzoic acid
CAS 307511-52-0C18H17N3O5S
4-{[(2-Fluorophenyl)sulfonyl]amino}-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one chemical structure, C17H16FN3O3S, CAS 612041-63-1
4-{[(2-Fluorophenyl)sulfonyl]amino}-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
CAS 612041-63-1C17H16FN3O3S
4-tert-Butyl-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-N-methylbenzenesulfonamide chemical structure, C22H27N3O3S, CAS 381241-77-6
4-tert-Butyl-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-N-methylbenzenesulfonamide
CAS 381241-77-6C22H27N3O3S
5-tert-Butyl-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2,3-dimethylbenzenesulfonamide chemical structure, C23H29N3O3S, CAS 670255-75-1
5-tert-Butyl-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2,3-dimethylbenzenesulfonamide
CAS 670255-75-1C23H29N3O3S