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Murcko scaffold

Ring system with 3 rings and 19 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
12
With full pages
3
Scaffold SMILES

c1ccc(SCc2cnc(-c3ccccc3)s2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(SCc2cnc(-c3ccccc3)s2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

GW 501516 chemical structure, C21H18F3NO3S2, CAS 317318-70-0
GW 501516
CAS 317318-70-0C21H18F3NO3S2
Sodelglitazar chemical structure, C23H21F4NO3S2, CAS 447406-78-2
Sodelglitazar
CAS 447406-78-2C23H21F4NO3S2
Ethyl 2-{2-methyl-4-[({4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetate chemical structure, C23H21F4NO3S2, CAS 317318-83-5
Ethyl 2-{2-methyl-4-[({4-methyl-2-[3-fluoro-4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetate
CAS 317318-83-5C23H21F4NO3S2
GW-0742 chemical structure, C21H17F4NO3S2, CAS 317318-84-6
GW-0742
CAS 317318-84-6C21H17F4NO3S2
2-Methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid chemical structure, C23H22F3NO3S2, CAS 1026868-55-2
2-Methyl-2-{2-methyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid
CAS 1026868-55-2C23H22F3NO3S2
GW 501516 methyl ester chemical structure, C22H20F3NO3S2, CAS 317318-69-7
GW 501516 methyl ester
CAS 317318-69-7C22H20F3NO3S2
2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid ethyl ester chemical structure, C23H22F3NO3S2, CAS 343322-83-8
2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic acid ethyl ester
CAS 343322-83-8C23H22F3NO3S2
2-Methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methyl)thio)phenol chemical structure, C19H16F3NOS2, CAS 636589-63-4
2-Methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methyl)thio)phenol
CAS 636589-63-4C19H16F3NOS2
2-[4-(Trifluoromethyl)phenyl]-5-[[(4-hydroxyphenyl)thio]methyl]thiazole-4-methanol chemical structure, C18H14F3NO2S2, CAS 676348-78-0
2-[4-(Trifluoromethyl)phenyl]-5-[[(4-hydroxyphenyl)thio]methyl]thiazole-4-methanol
CAS 676348-78-0C18H14F3NO2S2
4-[({2-[2-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methyl)thio]-2-methylphenol chemical structure, C19H15F4NOS2, CAS 447406-50-0
4-[({2-[2-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methyl)thio]-2-methylphenol
CAS 447406-50-0C19H15F4NOS2
N-Methyl-2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetamide chemical structure, C22H21F3N2O2S2, CAS 2375659-13-3
N-Methyl-2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetamide
CAS 2375659-13-3C22H21F3N2O2S2
(E)-3-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)phenyl)acrylic acid chemical structure, C21H15F4NO2S2, CAS 2770845-82-2
(E)-3-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)phenyl)acrylic acid
CAS 2770845-82-2C21H15F4NO2S2