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Murcko scaffold

Ring system with 5 rings and 38 atoms

13 chemicals on CompoundList share this ring system.

Rings
5
Scaffold atoms
38
Chemicals
13
With full pages
1
Scaffold SMILES

O=C1OCC(c2ccccc2)N1C(=O)C(CCCc1ccccc1)C(Nc1ccccc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1OCC(c2ccccc2)N1C(=O)C(CCCc1ccccc1)C(Nc1ccccc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

RefChem:403374 chemical structure, C39H46F2N2O5Si2, CAS 272778-12-8
RefChem:403374
CAS 272778-12-8C39H46F2N2O5Si2
(S)-3-((2R,5S)-2-((S)-(4-((tert-Butyldimethylsilyl)oxy)phenyl)((4-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one chemical structure, C39H44F2N2O5Si, CAS 1185883-46-8
(S)-3-((2R,5S)-2-((S)-(4-((tert-Butyldimethylsilyl)oxy)phenyl)((4-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one
CAS 1185883-46-8C39H44F2N2O5Si
(4S)-3-((2R,5S)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-hydroxyphenyl)methyl)-5-hydroxy-1-oxopentyl)-4-phenyl-2-oxazolidinone chemical structure, C33H30F2N2O5, CAS 1185883-40-2
(4S)-3-((2R,5S)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-hydroxyphenyl)methyl)-5-hydroxy-1-oxopentyl)-4-phenyl-2-oxazolidinone
CAS 1185883-40-2C33H30F2N2O5
4-((1S,2R)-5-Cyano-5-(4-fluorophenyl)-1-((4-fluorophenyl)amino)-2-((S)-2-oxo-4-phenyloxazolidine-3-carbonyl)-5-((trimethylsilyl)oxy)pentyl)phenyl pivalate chemical structure, C42H45F2N3O6Si, CAS 1232148-24-1
4-((1S,2R)-5-Cyano-5-(4-fluorophenyl)-1-((4-fluorophenyl)amino)-2-((S)-2-oxo-4-phenyloxazolidine-3-carbonyl)-5-((trimethylsilyl)oxy)pentyl)phenyl pivalate
CAS 1232148-24-1C42H45F2N3O6Si
Ezetimibe impurity 60 chemical structure, C39H46F2N2O5Si2, CAS 1809031-15-9
Ezetimibe impurity 60
CAS 1809031-15-9C39H46F2N2O5Si2
Xzz2PV9tra chemical structure, C38H40F2N2O6Si, CAS 1257306-29-8
Xzz2PV9tra
CAS 1257306-29-8C38H40F2N2O6Si
Ezetimibe impurity 49 chemical structure, C39H46F2N2O5Si2, CAS 2125942-22-3
Ezetimibe impurity 49
CAS 2125942-22-3C39H46F2N2O5Si2
(4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(R)-[(4-fluorophenyl)amino](4-hydroxyphenyl)methyl]-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone chemical structure, C33H30F2N2O5, CAS 1621715-63-6
(4S)-3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(R)-[(4-fluorophenyl)amino](4-hydroxyphenyl)methyl]-5-hydroxy-1-oxopentyl]-4-phenyl-2-oxazolidinone
CAS 1621715-63-6C33H30F2N2O5
Ezetimibe impurity 48 chemical structure, C39H46F2N2O5Si2, CAS 1650568-82-3
Ezetimibe impurity 48
CAS 1650568-82-3C39H46F2N2O5Si2
(S)-3-((2R,5R)-5-(4-Fluorophenyl)-2-((S)-(4-fluorophenylamino)(4-hydroxyphenyl)methyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one chemical structure, C33H30F2N2O5, CAS 1296129-16-2
(S)-3-((2R,5R)-5-(4-Fluorophenyl)-2-((S)-(4-fluorophenylamino)(4-hydroxyphenyl)methyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one
CAS 1296129-16-2C33H30F2N2O5
Ezetimibe impurity 138 chemical structure, C39H46F2N2O5Si2, CAS 2724503-24-4
Ezetimibe impurity 138
CAS 2724503-24-4C39H46F2N2O5Si2
(S)-3-((2R,5S)-5-((tert-Butyldimethylsilyl)oxy)-2-((S)-(4-((tert-butyldimethylsilyl)oxy)phenyl)((4-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)pentanoyl)-4-phenyloxazolidin-2-one chemical structure, C45H58F2N2O5Si2, CAS 1701462-59-0
(S)-3-((2R,5S)-5-((tert-Butyldimethylsilyl)oxy)-2-((S)-(4-((tert-butyldimethylsilyl)oxy)phenyl)((4-fluorophenyl)amino)methyl)-5-(4-fluorophenyl)pentanoyl)-4-phenyloxazolidin-2-one
CAS 1701462-59-0C45H58F2N2O5Si2
Ezetimibe impurity 104 chemical structure, C39H47FN2O5Si2, CAS 2280081-72-1
Ezetimibe impurity 104
CAS 2280081-72-1C39H47FN2O5Si2