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Murcko scaffold

2-(Piperazin-1-ylmethyl)quinazolin-4(3H)-one scaffold

7 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
7
With full pages
5
Scaffold SMILES

O=c1[nH]c(CN2CCNCC2)nc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(Piperazin-1-ylmethyl)quinazolin-4(3H)-one page
Murcko scaffold O=c1[nH]c(CN2CCNCC2)nc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 7 of 7 chemicals

2-(Piperazin-1-ylmethyl)quinazolin-4(3H)-one chemical structure, C13H16N4O, CAS 725690-23-3
2-(Piperazin-1-ylmethyl)quinazolin-4(3H)-one
CAS 725690-23-3C13H16N4O
2-{[4-(2-Hydroxyethyl)-1-piperazinyl]methyl}-4-quinazolinol chemical structure, C15H20N4O2, CAS 517869-86-2
2-{[4-(2-Hydroxyethyl)-1-piperazinyl]methyl}-4-quinazolinol
CAS 517869-86-2C15H20N4O2
2-[1-(4-Methylpiperazino)ethyl]-4(3H)-quinazolinone chemical structure, C15H20N4O, CAS 866009-95-2
2-[1-(4-Methylpiperazino)ethyl]-4(3H)-quinazolinone
CAS 866009-95-2C15H20N4O
4(3H)-Quinazolinone, 2-((4-methyl-1-piperazinyl)methyl)- chemical structure, C14H18N4O, CAS 19062-52-3
4(3H)-Quinazolinone, 2-((4-methyl-1-piperazinyl)methyl)-
CAS 19062-52-3C14H18N4O
4-[(4-Hydroxyquinazolin-2-yl)methyl]piperazine-1-carbaldehyde chemical structure, C14H16N4O2, CAS 890600-40-5
4-[(4-Hydroxyquinazolin-2-yl)methyl]piperazine-1-carbaldehyde
CAS 890600-40-5C14H16N4O2
2-[(Piperazin-1-yl)methyl]-3,4-dihydroquinazolin-4-one dihydrochloride chemical structure, C13H18Cl2N4O, CAS 1177287-65-8
2-[(Piperazin-1-yl)methyl]-3,4-dihydroquinazolin-4-one dihydrochloride
CAS 1177287-65-8C13H18Cl2N4O
2-[(Piperazin-1-yl)methyl]-3,4-dihydroquinazolin-4-one hydrochloride chemical structure, C13H17ClN4O, CAS 1158278-38-6
2-[(Piperazin-1-yl)methyl]-3,4-dihydroquinazolin-4-one hydrochloride
CAS 1158278-38-6C13H17ClN4O