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Murcko scaffold

5H,6H,7H,8H-Pyrido[3,4-b]pyrazine scaffold

29 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
29
With full pages
3
Scaffold SMILES

c1cnc2c(n1)CCNC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5H,6H,7H,8H-Pyrido[3,4-b]pyrazine page
Murcko scaffold c1cnc2c(n1)CCNC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

Diethyl 6-acetyl-5,6-dihydropyrido[3,4-b]pyrazine-7,7(8H)-dicarboxylate chemical structure, C15H19N3O5, CAS 264623-82-7
Diethyl 6-acetyl-5,6-dihydropyrido[3,4-b]pyrazine-7,7(8H)-dicarboxylate
CAS 264623-82-7C15H19N3O5
5,6,7,8-Tetrahydropyrido[3,4-b]pyrazine-7-carboxylic acid chemical structure, C8H9N3O2, CAS 764635-62-3
5,6,7,8-Tetrahydropyrido[3,4-b]pyrazine-7-carboxylic acid
CAS 764635-62-3C8H9N3O2
6-Methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-amine chemical structure, C8H12N4, CAS 785001-75-4
6-Methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-3-amine
CAS 785001-75-4C8H12N4
6-Methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine chemical structure, C8H12N4, CAS 777807-25-7
6-Methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazin-2-amine
CAS 777807-25-7C8H12N4
Methyl (7R)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine-7-carboxylate chemical structure, C9H11N3O2, CAS 752980-46-4
Methyl (7R)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine-7-carboxylate
CAS 752980-46-4C9H11N3O2
Methyl 5,6,7,8-tetrahydropyrido[4,3-b]pyrazine-7-carboxylate hydrochloride chemical structure, C9H12ClN3O2, CAS 264624-28-4
Methyl 5,6,7,8-tetrahydropyrido[4,3-b]pyrazine-7-carboxylate hydrochloride
CAS 264624-28-4C9H12ClN3O2
6-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine-7-carboxylic acid chemical structure, C13H17N3O4, CAS 264623-57-6
6-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine-7-carboxylic acid
CAS 264623-57-6C13H17N3O4
Ethyl 2-chloro-7,8-dihydropyrido[3,4-B]pyrazine-6(5H)-carboxylate chemical structure, C10H12ClN3O2, CAS 949922-49-0
Ethyl 2-chloro-7,8-dihydropyrido[3,4-B]pyrazine-6(5H)-carboxylate
CAS 949922-49-0C10H12ClN3O2
5-Methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine chemical structure, C8H11N3, CAS 757942-36-2
5-Methyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine
CAS 757942-36-2C8H11N3
5-Ethyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine chemical structure, C9H13N3, CAS 785777-01-7
5-Ethyl-5,6,7,8-tetrahydropyrido[3,4-b]pyrazine
CAS 785777-01-7C9H13N3
5H,6H,7H,8H-Pyrido[3,4-b]pyrazine chemical structure, C7H9N3, CAS 405162-62-1
5H,6H,7H,8H-Pyrido[3,4-b]pyrazine
CAS 405162-62-1C7H9N3
Ethyl 7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxylate chemical structure, C10H13N3O2, CAS 949922-48-9
Ethyl 7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxylate
CAS 949922-48-9C10H13N3O2
5,6,7,8-Tetrahydropyrido[3,4-b]pyrazine-7-carboxylic acid hydrochloride chemical structure, C8H10ClN3O2, CAS 264623-56-5
5,6,7,8-Tetrahydropyrido[3,4-b]pyrazine-7-carboxylic acid hydrochloride
CAS 264623-56-5C8H10ClN3O2
2-Chloro-5,6,7,8-tetrahydropyrido(3,4-b)pyrazine chemical structure, C7H8ClN3, CAS 1260670-14-1
2-Chloro-5,6,7,8-tetrahydropyrido(3,4-b)pyrazine
CAS 1260670-14-1C7H8ClN3
3-Chloro-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine chemical structure, C7H8ClN3, CAS 1260666-77-0
3-Chloro-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine
CAS 1260666-77-0C7H8ClN3
2-Methyl-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine chemical structure, C8H11N3, CAS 1260666-33-8
2-Methyl-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine
CAS 1260666-33-8C8H11N3
2-Methoxy-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine chemical structure, C8H11N3O, CAS 1260663-33-9
2-Methoxy-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine
CAS 1260663-33-9C8H11N3O
2-Bromo-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine chemical structure, C7H8BrN3, CAS 1393570-06-3
2-Bromo-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine
CAS 1393570-06-3C7H8BrN3
2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine chemical structure, C8H8F3N3, CAS 1211528-43-6
2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine
CAS 1211528-43-6C8H8F3N3
5,6,7,8-Tetrahydropyrido[3,4-b]pyrazine hydrochloride chemical structure, C7H10ClN3, CAS 1955520-74-7
5,6,7,8-Tetrahydropyrido[3,4-b]pyrazine hydrochloride
CAS 1955520-74-7C7H10ClN3
5,6,7,8-Tetrahydropyrido[3,4-b]pyrazine-5-carboxylic acid chemical structure, C8H9N3O2, CAS 1367705-68-7
5,6,7,8-Tetrahydropyrido[3,4-b]pyrazine-5-carboxylic acid
CAS 1367705-68-7C8H9N3O2
(R)-6-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine-7-carboxylic acid chemical structure, C13H17N3O4, CAS 264623-58-7
(R)-6-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydropyrido[3,4-B]pyrazine-7-carboxylic acid
CAS 264623-58-7C13H17N3O4
tert-Butyl 3-chloro-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxylate chemical structure, C12H16ClN3O2, CAS 1823793-09-4
tert-Butyl 3-chloro-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxylate
CAS 1823793-09-4C12H16ClN3O2
tert-Butyl 3-amino-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxylate chemical structure, C12H18N4O2, CAS 1936323-76-0
tert-Butyl 3-amino-7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxylate
CAS 1936323-76-0C12H18N4O2