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Murcko scaffold

Ring system with 2 rings and 21 atoms

41 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
21
Chemicals
41
With full pages
5
Scaffold SMILES

O=C(COC(=O)Cc1ccccc1)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COC(=O)Cc1ccccc1)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

{[(4-Fluorophenyl)methyl]carbamoyl}methyl 2-(4-chlorophenyl)acetate chemical structure, C17H15ClFNO3, CAS 757208-57-4
{[(4-Fluorophenyl)methyl]carbamoyl}methyl 2-(4-chlorophenyl)acetate
CAS 757208-57-4C17H15ClFNO3
[2-[(2-Methoxyphenyl)methylamino]-2-oxoethyl] 2-(4-bromophenyl)acetate chemical structure, C18H18BrNO4, CAS 380179-44-2
[2-[(2-Methoxyphenyl)methylamino]-2-oxoethyl] 2-(4-bromophenyl)acetate
CAS 380179-44-2C18H18BrNO4
[2-[Benzyl(methyl)amino]-2-oxoethyl] 2-(4-chlorophenyl)acetate chemical structure, C18H18ClNO3, CAS 380214-34-6
[2-[Benzyl(methyl)amino]-2-oxoethyl] 2-(4-chlorophenyl)acetate
CAS 380214-34-6C18H18ClNO3
[2-[(4-Methoxyphenyl)methylamino]-2-oxoethyl] 2-(4-bromophenyl)acetate chemical structure, C18H18BrNO4, CAS 728893-40-1
[2-[(4-Methoxyphenyl)methylamino]-2-oxoethyl] 2-(4-bromophenyl)acetate
CAS 728893-40-1C18H18BrNO4
[2-[(3,4-Dimethoxyphenyl)methylamino]-2-oxoethyl] 2-(4-chlorophenyl)acetate chemical structure, C19H20ClNO5, CAS 1002164-37-5
[2-[(3,4-Dimethoxyphenyl)methylamino]-2-oxoethyl] 2-(4-chlorophenyl)acetate
CAS 1002164-37-5C19H20ClNO5
[2-[(4-Methylphenyl)methylamino]-2-oxoethyl] 2-(4-chlorophenyl)acetate chemical structure, C18H18ClNO3, CAS 1002164-93-3
[2-[(4-Methylphenyl)methylamino]-2-oxoethyl] 2-(4-chlorophenyl)acetate
CAS 1002164-93-3C18H18ClNO3
{[(2-Chlorophenyl)methyl]carbamoyl}methyl 2-(4-chlorophenyl)acetate chemical structure, C17H15Cl2NO3, CAS 391239-89-7
{[(2-Chlorophenyl)methyl]carbamoyl}methyl 2-(4-chlorophenyl)acetate
CAS 391239-89-7C17H15Cl2NO3
[2-[(4-Methoxyphenyl)methylamino]-2-oxoethyl] 2-(4-chlorophenyl)acetate chemical structure, C18H18ClNO4, CAS 1003101-80-1
[2-[(4-Methoxyphenyl)methylamino]-2-oxoethyl] 2-(4-chlorophenyl)acetate
CAS 1003101-80-1C18H18ClNO4
[2-[(4-Chlorophenyl)methylamino]-2-oxoethyl] 2-(2-fluorophenyl)acetate chemical structure, C17H15ClFNO3, CAS 399028-49-0
[2-[(4-Chlorophenyl)methylamino]-2-oxoethyl] 2-(2-fluorophenyl)acetate
CAS 399028-49-0C17H15ClFNO3
[2-[(3-Methoxyphenyl)methylamino]-2-oxoethyl] 2-(4-chlorophenyl)acetate chemical structure, C18H18ClNO4, CAS 1003236-52-9
[2-[(3-Methoxyphenyl)methylamino]-2-oxoethyl] 2-(4-chlorophenyl)acetate
CAS 1003236-52-9C18H18ClNO4
2-[(4-Fluorobenzyl)amino]-2-oxoethyl (3-methoxyphenyl)acetate chemical structure, C18H18FNO4, CAS 1002267-61-9
2-[(4-Fluorobenzyl)amino]-2-oxoethyl (3-methoxyphenyl)acetate
CAS 1002267-61-9C18H18FNO4
2-(Benzylamino)-2-oxoethyl (3-methoxyphenyl)acetate chemical structure, C18H19NO4, CAS 1004126-87-7
2-(Benzylamino)-2-oxoethyl (3-methoxyphenyl)acetate
CAS 1004126-87-7C18H19NO4
2-(Benzylamino)-2-oxoethyl (4-methylphenyl)acetate chemical structure, C18H19NO3, CAS 1351828-76-6
2-(Benzylamino)-2-oxoethyl (4-methylphenyl)acetate
CAS 1351828-76-6C18H19NO3
2-[(2-Chlorobenzyl)amino]-2-oxoethyl (4-methylphenyl)acetate chemical structure, C18H18ClNO3, CAS 1797253-02-1
2-[(2-Chlorobenzyl)amino]-2-oxoethyl (4-methylphenyl)acetate
CAS 1797253-02-1C18H18ClNO3
2-[(3,4-Dimethoxybenzyl)amino]-2-oxoethyl (4-methylphenyl)acetate chemical structure, C20H23NO5, CAS 1288725-08-5
2-[(3,4-Dimethoxybenzyl)amino]-2-oxoethyl (4-methylphenyl)acetate
CAS 1288725-08-5C20H23NO5
2-[(3-Methoxybenzyl)amino]-2-oxoethyl (4-methylphenyl)acetate chemical structure, C19H21NO4, CAS 1797137-32-6
2-[(3-Methoxybenzyl)amino]-2-oxoethyl (4-methylphenyl)acetate
CAS 1797137-32-6C19H21NO4
[2-[(4-Fluorophenyl)methylamino]-2-oxoethyl] 2-(3-fluorophenyl)acetate chemical structure, C17H15F2NO3, CAS 1794833-94-5
[2-[(4-Fluorophenyl)methylamino]-2-oxoethyl] 2-(3-fluorophenyl)acetate
CAS 1794833-94-5C17H15F2NO3
[2-(Benzylamino)-2-oxoethyl] 2-(3-fluorophenyl)acetate chemical structure, C17H16FNO3, CAS 1794938-42-3
[2-(Benzylamino)-2-oxoethyl] 2-(3-fluorophenyl)acetate
CAS 1794938-42-3C17H16FNO3
{[(4-Methylphenyl)methyl]carbamoyl}methyl 2-(3-fluorophenyl)acetate chemical structure, C18H18FNO3, CAS 923818-11-5
{[(4-Methylphenyl)methyl]carbamoyl}methyl 2-(3-fluorophenyl)acetate
CAS 923818-11-5C18H18FNO3
{[(4-Methylphenyl)methyl]carbamoyl}methyl 2-(2-methoxyphenyl)acetate chemical structure, C19H21NO4, CAS 1351771-57-7
{[(4-Methylphenyl)methyl]carbamoyl}methyl 2-(2-methoxyphenyl)acetate
CAS 1351771-57-7C19H21NO4
{[(4-Methylphenyl)methyl]carbamoyl}methyl 2-(4-methylphenyl)acetate chemical structure, C19H21NO3, CAS 1798016-52-0
{[(4-Methylphenyl)methyl]carbamoyl}methyl 2-(4-methylphenyl)acetate
CAS 1798016-52-0C19H21NO3
2-[(4-Methoxybenzyl)amino]-2-oxoethyl (4-methylphenyl)acetate chemical structure, C19H21NO4, CAS 1797196-30-5
2-[(4-Methoxybenzyl)amino]-2-oxoethyl (4-methylphenyl)acetate
CAS 1797196-30-5C19H21NO4
2-[(4-Fluorobenzyl)amino]-2-oxoethyl (4-methylphenyl)acetate chemical structure, C18H18FNO3, CAS 1798016-75-7
2-[(4-Fluorobenzyl)amino]-2-oxoethyl (4-methylphenyl)acetate
CAS 1798016-75-7C18H18FNO3
{[(4-Chlorophenyl)methyl]carbamoyl}methyl 2-phenylbutanoate chemical structure, C19H20ClNO3, CAS 400061-18-9
{[(4-Chlorophenyl)methyl]carbamoyl}methyl 2-phenylbutanoate
CAS 400061-18-9C19H20ClNO3