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Murcko scaffold

2-(3-Oxopiperazin-2-yl)-N-phenylacetamide scaffold

72 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
17
Chemicals
72
With full pages
22
Scaffold SMILES

O=C(CC1NCCNC1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(3-Oxopiperazin-2-yl)-N-phenylacetamide page
Murcko scaffold O=C(CC1NCCNC1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 72 chemicals

N-(2-Nitrophenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C12H14N4O4, CAS 367928-08-3
N-(2-Nitrophenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 367928-08-3C12H14N4O4
N-(4-Fluorophenyl)-2-[1-(3-methylbutyl)-3-oxopiperazin-2-yl]acetamide chemical structure, C17H24FN3O2, CAS 1009496-57-4
N-(4-Fluorophenyl)-2-[1-(3-methylbutyl)-3-oxopiperazin-2-yl]acetamide
CAS 1009496-57-4C17H24FN3O2
N-(2,5-Dichlorophenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C12H13Cl2N3O2, CAS 61832-94-8
N-(2,5-Dichlorophenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 61832-94-8C12H13Cl2N3O2
N-(4-Methoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C13H17N3O3, CAS 685088-79-3
N-(4-Methoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 685088-79-3C13H17N3O3
2-(3-Oxopiperazin-2-yl)-N-[4-(propan-2-yl)phenyl]acetamide chemical structure, C15H21N3O2, CAS 710945-30-5
2-(3-Oxopiperazin-2-yl)-N-[4-(propan-2-yl)phenyl]acetamide
CAS 710945-30-5C15H21N3O2
N-(4-Ethoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C14H19N3O3, CAS 1008283-00-8
N-(4-Ethoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1008283-00-8C14H19N3O3
N-(4-Methylphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C13H17N3O2, CAS 1009340-90-2
N-(4-Methylphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009340-90-2C13H17N3O2
N-(3-Chlorophenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C12H14ClN3O2, CAS 1008069-02-0
N-(3-Chlorophenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1008069-02-0C12H14ClN3O2
N-(2,5-Dimethoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C14H19N3O4, CAS 1009674-90-1
N-(2,5-Dimethoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009674-90-1C14H19N3O4
N-(3-Chloro-2-methylphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C13H16ClN3O2, CAS 1009501-28-3
N-(3-Chloro-2-methylphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009501-28-3C13H16ClN3O2
N-(4-Fluorophenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C12H14FN3O2, CAS 1008483-20-2
N-(4-Fluorophenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1008483-20-2C12H14FN3O2
2-(3-Oxopiperazin-2-yl)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C13H14F3N3O2, CAS 1009323-15-2
2-(3-Oxopiperazin-2-yl)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 1009323-15-2C13H14F3N3O2
N-(5-Chloro-2-methoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C13H16ClN3O3, CAS 1009279-16-6
N-(5-Chloro-2-methoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009279-16-6C13H16ClN3O3
N-(4-Nitrophenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C12H14N4O4, CAS 1009701-33-0
N-(4-Nitrophenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009701-33-0C12H14N4O4
N-(3,5-Dimethylphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C14H19N3O2, CAS 1009664-79-2
N-(3,5-Dimethylphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009664-79-2C14H19N3O2
N-(3-Methoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C13H17N3O3, CAS 1009505-81-0
N-(3-Methoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009505-81-0C13H17N3O3
N-(2-Ethylphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C14H19N3O2, CAS 1009619-30-0
N-(2-Ethylphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009619-30-0C14H19N3O2
2-(3-Oxopiperazin-2-yl)-N-phenylacetamide chemical structure, C12H15N3O2, CAS 19564-10-4
2-(3-Oxopiperazin-2-yl)-N-phenylacetamide
CAS 19564-10-4C12H15N3O2
N-(3-Chloro-4-methylphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C13H16ClN3O2, CAS 1009230-47-0
N-(3-Chloro-4-methylphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009230-47-0C13H16ClN3O2
N-(3-Methylphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C13H17N3O2, CAS 1009505-63-8
N-(3-Methylphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009505-63-8C13H17N3O2
4-[2-(3-Oxo-piperazin-2-yl)-acetylamino]-benzoic acid ethyl ester chemical structure, C15H19N3O4, CAS 1009534-08-0
4-[2-(3-Oxo-piperazin-2-yl)-acetylamino]-benzoic acid ethyl ester
CAS 1009534-08-0C15H19N3O4
N-(2-Ethoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C14H19N3O3, CAS 1009236-38-7
N-(2-Ethoxyphenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1009236-38-7C14H19N3O3
N-(3-Nitrophenyl)-2-(3-oxopiperazin-2-yl)acetamide chemical structure, C12H14N4O4, CAS 1008069-42-8
N-(3-Nitrophenyl)-2-(3-oxopiperazin-2-yl)acetamide
CAS 1008069-42-8C12H14N4O4
2-(1-(Allylcarbamothioyl)-3-oxopiperazin-2-yl)-N-(5-chloro-2-methoxyphenyl)acetamide chemical structure, C17H21ClN4O3S, CAS 1009249-70-0
2-(1-(Allylcarbamothioyl)-3-oxopiperazin-2-yl)-N-(5-chloro-2-methoxyphenyl)acetamide
CAS 1009249-70-0C17H21ClN4O3S