CompoundList
Sign in
Murcko scaffold

Pyrimidine, 2-(2-pyridinyl)- scaffold

220 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
220
With full pages
39
Scaffold SMILES

c1ccc(-c2ncccn2)nc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Pyrimidine, 2-(2-pyridinyl)- page
Murcko scaffold c1ccc(-c2ncccn2)nc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 220 chemicals

5-Methoxy-N-(1-methylethyl)-2-(2-pyridinyl)-4-pyrimidinamine chemical structure, C13H16N4O, CAS 338771-57-6
5-Methoxy-N-(1-methylethyl)-2-(2-pyridinyl)-4-pyrimidinamine
CAS 338771-57-6C13H16N4O
Ethyl 2-((5-methoxy-2-(2-pyridinyl)-4-pyrimidinyl)sulfanyl)acetate chemical structure, C14H15N3O3S, CAS 338771-59-8
Ethyl 2-((5-methoxy-2-(2-pyridinyl)-4-pyrimidinyl)sulfanyl)acetate
CAS 338771-59-8C14H15N3O3S
Ethyl 2-((6-((methylsulfanyl)methyl)-2-(2-pyridinyl)-4-pyrimidinyl)sulfanyl)acetate chemical structure, C15H17N3O2S2, CAS 477886-24-1
Ethyl 2-((6-((methylsulfanyl)methyl)-2-(2-pyridinyl)-4-pyrimidinyl)sulfanyl)acetate
CAS 477886-24-1C15H17N3O2S2
4-(Dimethoxymethyl)-2-(pyridin-2-yl)pyrimidine chemical structure, C12H13N3O2, CAS 156825-33-1
4-(Dimethoxymethyl)-2-(pyridin-2-yl)pyrimidine
CAS 156825-33-1C12H13N3O2
5-Methoxy-N,N-dimethyl-2-(pyridin-2-yl)pyrimidin-4-amine chemical structure, C12H14N4O, CAS 338410-58-5
5-Methoxy-N,N-dimethyl-2-(pyridin-2-yl)pyrimidin-4-amine
CAS 338410-58-5C12H14N4O
4-Isopropoxy-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C13H15N3O2, CAS 400081-17-6
4-Isopropoxy-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 400081-17-6C13H15N3O2
Methyl 2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl ether chemical structure, C11H8F3N3O, CAS 338418-04-5
Methyl 2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl ether
CAS 338418-04-5C11H8F3N3O
N-Methyl-2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinamine chemical structure, C11H9F3N4, CAS 338418-10-3
N-Methyl-2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinamine
CAS 338418-10-3C11H9F3N4
N,N-Dimethyl-2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinamine chemical structure, C12H11F3N4, CAS 338418-11-4
N,N-Dimethyl-2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinamine
CAS 338418-11-4C12H11F3N4
Methyl 2-{[2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]sulfanyl}acetate chemical structure, C13H10F3N3O2S, CAS 338418-14-7
Methyl 2-{[2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]sulfanyl}acetate
CAS 338418-14-7C13H10F3N3O2S
4-(Methylsulfanyl)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine chemical structure, C11H8F3N3S, CAS 338418-17-0
4-(Methylsulfanyl)-2-(2-pyridinyl)-6-(trifluoromethyl)pyrimidine
CAS 338418-17-0C11H8F3N3S
N,N-Diethyl-2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinamine chemical structure, C14H15F3N4, CAS 338418-20-5
N,N-Diethyl-2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinamine
CAS 338418-20-5C14H15F3N4
N-Isopropyl-2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinamine chemical structure, C13H13F3N4, CAS 338418-21-6
N-Isopropyl-2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinamine
CAS 338418-21-6C13H13F3N4
2-{[2-(2-Pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]sulfanyl}acetic acid chemical structure, C12H8F3N3O2S, CAS 338418-26-1
2-{[2-(2-Pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]sulfanyl}acetic acid
CAS 338418-26-1C12H8F3N3O2S
N-Methyl-2-{[2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]sulfanyl}acetamide chemical structure, C13H11F3N4OS, CAS 400081-63-2
N-Methyl-2-{[2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]sulfanyl}acetamide
CAS 400081-63-2C13H11F3N4OS
Ethyl 2-{[2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]sulfanyl}acetate chemical structure, C14H12F3N3O2S, CAS 338418-30-7
Ethyl 2-{[2-(2-pyridinyl)-6-(trifluoromethyl)-4-pyrimidinyl]sulfanyl}acetate
CAS 338418-30-7C14H12F3N3O2S
Ethyl 2-(pyridin-2-yl)-4-(trifluoromethyl)pyrimidine-5-carboxylate chemical structure, C13H10F3N3O2, CAS 866132-66-3
Ethyl 2-(pyridin-2-yl)-4-(trifluoromethyl)pyrimidine-5-carboxylate
CAS 866132-66-3C13H10F3N3O2
4-Amino-5-cyano-2-(2-pyridyl)pyrimidine chemical structure, C10H7N5, CAS 874772-63-1
4-Amino-5-cyano-2-(2-pyridyl)pyrimidine
CAS 874772-63-1C10H7N5
4,5-Dichloro-6-methyl-2-(pyridin-2-yl)pyrimidine chemical structure, C10H7Cl2N3, CAS 306935-55-7
4,5-Dichloro-6-methyl-2-(pyridin-2-yl)pyrimidine
CAS 306935-55-7C10H7Cl2N3
4-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine chemical structure, C10H8ClN3, CAS 77168-31-1
4-Chloro-6-methyl-2-(pyridin-2-yl)pyrimidine
CAS 77168-31-1C10H8ClN3
4-Chloro-5-methoxy-2-(2-pyridinyl)pyrimidine chemical structure, C10H8ClN3O, CAS 321432-82-0
4-Chloro-5-methoxy-2-(2-pyridinyl)pyrimidine
CAS 321432-82-0C10H8ClN3O
5-(Isopropylsulfonyl)-2-(2-pyridyl)pyrimidin-4-amine chemical structure, C12H14N4O2S, CAS 175202-02-5
5-(Isopropylsulfonyl)-2-(2-pyridyl)pyrimidin-4-amine
CAS 175202-02-5C12H14N4O2S
5-(2-Methylpropane-2-sulfonyl)-2-(pyridin-2-yl)pyrimidin-4-amine chemical structure, C13H16N4O2S, CAS 175202-19-4
5-(2-Methylpropane-2-sulfonyl)-2-(pyridin-2-yl)pyrimidin-4-amine
CAS 175202-19-4C13H16N4O2S
4,5-Dichloro-6-methyl-2-[5-(trifluoromethyl)-2-pyridyl]pyrimidine chemical structure, C11H6Cl2F3N3, CAS 266679-65-6
4,5-Dichloro-6-methyl-2-[5-(trifluoromethyl)-2-pyridyl]pyrimidine
CAS 266679-65-6C11H6Cl2F3N3