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Murcko scaffold

1,3-Diphenyl-2-thioxoimidazolidin-4-one scaffold

34 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
34
With full pages
7
Scaffold SMILES

O=C1CN(c2ccccc2)C(=S)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,3-Diphenyl-2-thioxoimidazolidin-4-one page
Murcko scaffold O=C1CN(c2ccccc2)C(=S)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

3-(4-Chlorophenyl)-1-phenyl-2-sulfanylideneimidazolidin-4-one chemical structure, C15H11ClN2OS, CAS 15355-80-3
3-(4-Chlorophenyl)-1-phenyl-2-sulfanylideneimidazolidin-4-one
CAS 15355-80-3C15H11ClN2OS
1,3-Diphenyl-2-thioxoimidazolidin-4-one chemical structure, C15H12N2OS, CAS 15355-79-0
1,3-Diphenyl-2-thioxoimidazolidin-4-one
CAS 15355-79-0C15H12N2OS
1-(4-Methoxyphenyl)-3-phenyl-2-thioxoimidazolidin-4-one chemical structure, C16H14N2O2S, CAS 692282-10-3
1-(4-Methoxyphenyl)-3-phenyl-2-thioxoimidazolidin-4-one
CAS 692282-10-3C16H14N2O2S
2-Chloro-5-(3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)benzenesulfonamide chemical structure, C18H14Cl2N4O3S2, CAS 879614-64-9
2-Chloro-5-(3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)benzenesulfonamide
CAS 879614-64-9C18H14Cl2N4O3S2
4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)benzenesulfonamide chemical structure, C19H15F3N4O3S2, CAS 879613-97-5
4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)benzenesulfonamide
CAS 879613-97-5C19H15F3N4O3S2
3-(3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)benzenesulfonamide chemical structure, C18H15ClN4O3S2, CAS 879614-19-4
3-(3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)benzenesulfonamide
CAS 879614-19-4C18H15ClN4O3S2
5,5-Dimethyl-1,3-diphenyl-2-sulfanylideneimidazolidin-4-one chemical structure, C17H16N2OS, CAS 87976-12-3
5,5-Dimethyl-1,3-diphenyl-2-sulfanylideneimidazolidin-4-one
CAS 87976-12-3C17H16N2OS
Methyl 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]benzoate chemical structure, C21H16F3N3O3S, CAS 915087-15-9
Methyl 4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]benzoate
CAS 915087-15-9C21H16F3N3O3S
Defluoro enzalutamide chemical structure, C21H17F3N4O2S, CAS 915087-16-0
Defluoro enzalutamide
CAS 915087-16-0C21H17F3N4O2S
Enzalutamide chemical structure, C21H16F4N4O2S, CAS 915087-33-1
Enzalutamide
CAS 915087-33-1C21H16F4N4O2S
4-(3-(4-Hydroxyphenyl)-4,4-diMethyl-5-oxo-2-thioxoiMidazolidin-1-yl)-2-(trifluoroMethyl)benzonitrile chemical structure, C19H14F3N3O2S, CAS 915086-32-7
4-(3-(4-Hydroxyphenyl)-4,4-diMethyl-5-oxo-2-thioxoiMidazolidin-1-yl)-2-(trifluoroMethyl)benzonitrile
CAS 915086-32-7C19H14F3N3O2S
4-[3-Phenyl-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile chemical structure, C19H14F3N3OS, CAS 915086-36-1
4-[3-Phenyl-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile
CAS 915086-36-1C19H14F3N3OS
4-[3-(4-Aminophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile chemical structure, C19H15F3N4OS, CAS 915086-29-2
4-[3-(4-Aminophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile
CAS 915086-29-2C19H15F3N4OS
Enzalutamide carboxylic acid chemical structure, C20H13F4N3O3S, CAS 1242137-15-0
Enzalutamide carboxylic acid
CAS 1242137-15-0C20H13F4N3O3S
N-(tert-Butyl)-4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzamide chemical structure, C24H22F4N4O2S, CAS 1251529-74-4
N-(tert-Butyl)-4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluorobenzamide
CAS 1251529-74-4C24H22F4N4O2S
Androgen receptor antagonist 2 chemical structure, C21H15F5N4O2S, CAS 1272719-00-2
Androgen receptor antagonist 2
CAS 1272719-00-2C21H15F5N4O2S
4-(3-(3-Amino-4-chlorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-chlorobenzonitrile chemical structure, C18H14Cl2N4OS, CAS 879615-23-3
4-(3-(3-Amino-4-chlorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-chlorobenzonitrile
CAS 879615-23-3C18H14Cl2N4OS
N-Desmethylenzalutamide chemical structure, C20H14F4N4O2S, CAS 1242137-16-1
N-Desmethylenzalutamide
CAS 1242137-16-1C20H14F4N4O2S
Deutenzalutamide chemical structure, C21H16F4N4O2S, CAS 1443331-82-5
Deutenzalutamide
CAS 1443331-82-5C21H16F4N4O2S
Enzalutamide-d6 chemical structure, C21H16F4N4O2S, CAS 1443331-94-9
Enzalutamide-d6
CAS 1443331-94-9C21H16F4N4O2S
N-Desmethyl enzalutamide-d6 chemical structure, C20H14F4N4O2S, CAS 2748567-63-5
N-Desmethyl enzalutamide-d6
CAS 2748567-63-5C20H14F4N4O2S
Enzalutamide impurity 10 chemical structure, C22H18F4N4O2S, CAS 1443331-78-9
Enzalutamide impurity 10
CAS 1443331-78-9C22H18F4N4O2S
4-(3-(3-Amino-4-chlorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile chemical structure, C19H14ClF3N4OS, CAS 879615-02-8
4-(3-(3-Amino-4-chlorophenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
CAS 879615-02-8C19H14ClF3N4OS
4-(3-(3-Fluoro-4-hydroxyphenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile chemical structure, C19H13F4N3O2S, CAS 1572045-71-6
4-(3-(3-Fluoro-4-hydroxyphenyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile
CAS 1572045-71-6C19H13F4N3O2S