Murcko scaffold
Ring system with 3 rings and 16 atoms
102 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 16
- Chemicals
- 102
- With full pages
- 12
Scaffold SMILES
c1ccc(Cn2ncc3cccnc32)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 102 chemicals
![1-Benzyl-3-methyl-1H-pyrazolo[3,4-b]pyridine chemical structure, C14H13N3, CAS 96793-52-1](/s/GLYFDIZBHQMLAU-UHFFFAOYSA-N.svg)
1-Benzyl-3-methyl-1H-pyrazolo[3,4-b]pyridine
CAS 96793-52-1C14H13N3
![1-[(4-Ethylphenyl)methyl]-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C17H17N3O2, CAS 871497-71-1](/s/YXAPTGNGBICIOX-UHFFFAOYSA-N.svg)
1-[(4-Ethylphenyl)methyl]-6-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 871497-71-1C17H17N3O2
![6-Methyl-1-[(4-methylphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C16H15N3O2, CAS 871548-24-2](/s/YYXAQSFNYXGRGR-UHFFFAOYSA-N.svg)
6-Methyl-1-[(4-methylphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 871548-24-2C16H15N3O2
3-Ethoxycarbonyl-1-(2-fluorbenzyl)-1H-pyrazolo-(3,4,5)-pyridin
CAS 256376-59-7C16H14FN3O2
![Methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbiMidate chemical structure, C15H13FN4O, CAS 304874-06-4](/s/WSKGRWHECMNHBT-UHFFFAOYSA-N.svg)
Methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbiMidate
CAS 304874-06-4C15H13FN4O
![1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide chemical structure, C14H11FN4O, CAS 256376-62-2](/s/GWDSAMDSGSEPRH-UHFFFAOYSA-N.svg)
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide
CAS 256376-62-2C14H11FN4O
1-((2-Fluorophenyl)methyl)pyrazolo(3,4-b)pyridine-3-carbonitrile
CAS 256376-65-5C14H9FN4
![1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide chemical structure, C14H12FN5, CAS 256376-68-8](/s/LQCFFAGUCURQEC-UHFFFAOYSA-N.svg)
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide
CAS 256376-68-8C14H12FN5
![1-[(2,4-Dichlorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid chemical structure, C14H9Cl2N3O2, CAS 875577-77-8](/s/KBMUEXIDLFRWCH-UHFFFAOYSA-N.svg)
1-[(2,4-Dichlorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid
CAS 875577-77-8C14H9Cl2N3O2
![1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid chemical structure, C14H10FN3O2, CAS 956011-26-0](/s/QOMRCMAKWINLAN-UHFFFAOYSA-N.svg)
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid
CAS 956011-26-0C14H10FN3O2
![1-Benzyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid chemical structure, C14H11N3O2, CAS 929975-85-9](/s/AGYISJXWVIAJSA-UHFFFAOYSA-N.svg)
1-Benzyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
CAS 929975-85-9C14H11N3O2
![1-(1-Phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid chemical structure, C15H13N3O2, CAS 926223-68-9](/s/LPBQSRGEAVUYPB-UHFFFAOYSA-N.svg)
1-(1-Phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
CAS 926223-68-9C15H13N3O2
![1-[(2,4-Dimethoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid chemical structure, C16H15N3O4, CAS 937623-70-6](/s/CBCVYCCUGFAPAF-UHFFFAOYSA-N.svg)
1-[(2,4-Dimethoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
CAS 937623-70-6C16H15N3O4
![1-[(3-Chlorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid chemical structure, C14H10ClN3O2, CAS 937620-78-5](/s/OZYDHRYNEROSMG-UHFFFAOYSA-N.svg)
1-[(3-Chlorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
CAS 937620-78-5C14H10ClN3O2
![1-[(4-Chlorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid chemical structure, C14H10ClN3O2, CAS 937621-08-4](/s/TVXHGFFVRKTYJS-UHFFFAOYSA-N.svg)
1-[(4-Chlorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
CAS 937621-08-4C14H10ClN3O2
![1-[(2-Chlorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid chemical structure, C14H10ClN3O2, CAS 937608-35-0](/s/ORPORIACAMLZTO-UHFFFAOYSA-N.svg)
1-[(2-Chlorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
CAS 937608-35-0C14H10ClN3O2
![5-Bromo-4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine chemical structure, C14H11BrClN3O, CAS 370866-02-7](/s/OVXSPZSVXMKIMI-UHFFFAOYSA-N.svg)
5-Bromo-4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine
CAS 370866-02-7C14H11BrClN3O
![4-Butoxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid chemical structure, C19H21N3O4, CAS 227617-17-6](/s/UOBWETMYGDGRAP-UHFFFAOYSA-N.svg)
4-Butoxy-1-[(4-methoxyphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid
CAS 227617-17-6C19H21N3O4
![1-Benzyl-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C16H15N3O2, CAS 937597-56-3](/s/LLLVXJSFYCPFLA-UHFFFAOYSA-N.svg)
1-Benzyl-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 937597-56-3C16H15N3O2
![1-(4-Chlorobenzyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C16H14ClN3O2, CAS 937597-74-5](/s/LIWUKOYOBBJUTC-UHFFFAOYSA-N.svg)
1-(4-Chlorobenzyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 937597-74-5C16H14ClN3O2
![1-(4-Chlorobenzyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide chemical structure, C16H16ClN5O, CAS 938006-72-5](/s/VPMQOZWAUIKRCV-UHFFFAOYSA-N.svg)
1-(4-Chlorobenzyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide
CAS 938006-72-5C16H16ClN5O
![1-(2-Chlorobenzyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid chemical structure, C16H14ClN3O2, CAS 937597-77-8](/s/XGFMAEQDTFHSSJ-UHFFFAOYSA-N.svg)
1-(2-Chlorobenzyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
CAS 937597-77-8C16H14ClN3O2
![Ethyl 1-benzyl-4-chloro-1H-pyrazolo[3,4-B]pyridine-5-carboxylate chemical structure, C16H14ClN3O2, CAS 37801-55-1](/s/UWYJDOGXOBVINO-UHFFFAOYSA-N.svg)
Ethyl 1-benzyl-4-chloro-1H-pyrazolo[3,4-B]pyridine-5-carboxylate
CAS 37801-55-1C16H14ClN3O2
![1-Benzylpyrazolo[5,4-b]pyridin-3-amine chemical structure, C13H12N4, CAS 438622-07-2](/s/UZTATAVQJLHOKI-UHFFFAOYSA-N.svg)
1-Benzylpyrazolo[5,4-b]pyridin-3-amine
CAS 438622-07-2C13H12N4
- 5-Bromo-1-[(4-methylphenyl)methyl]-1H-pyrazolo[3,4-b]pyridine1017042-13-5C14H12BrN3
- 1-Benzyl-5-bromo-1H-pyrazolo[3,4-b]pyridine1016804-09-3C13H10BrN3
- 5-Bromo-1-(2-chlorobenzyl)-1H-pyrazolo[3,4-b]pyridine1016804-61-7C13H9BrClN3
- Methyl 1-(4-chlorobenzyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate1011370-91-4C17H16ClN3O2
- 5-Chloro-3,6-dimethyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid1011399-21-5C17H16ClN3O2
- Methyl 1-(2-chlorobenzyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate1011359-95-7C17H16ClN3O2
- Methyl 5-chloro-3,6-dimethyl-1-(4-methylbenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate1011398-07-4C18H18ClN3O2
- 1-Benzyl-6-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid1018151-22-8C17H17N3O2
- 6-Ethyl-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid1120284-75-4C17H17N3O3
- 1-(3-Chlorobenzyl)-4-(difluoromethyl)-3,6-dimethyl-1H-pyrazolo[3,4-b]pyridine1011372-28-3C16H14ClF2N3
- 1-((2-Chlorophenyl)methyl)-3,6-dimethyl-4-(trifluoromethyl)-1H-pyrazolo(3,4-b)pyridine1011398-70-1C16H13ClF3N3
- 1-(4-Chlorobenzyl)-3,6-dimethyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine1011401-39-0C16H13ClF3N3
- 3,6-Dimethyl-1-(4-methylbenzyl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine1011391-49-3C17H16F3N3
- 1-Benzyl-3-methyl-1H-pyrazolo(3,4-b)pyridin-5-amine1211409-49-2C14H14N4
- Ethyl 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate227617-16-5C17H16ClN3O3
- 4-Butoxy-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazolo[3,4-B]pyridine-5-carboxamide227617-18-7C21H26N4O4
- 4 suppliers5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile1350653-26-7C14H8F2N4
- 5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxamide1361232-73-6C14H10F2N4O
- Methyl 5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-3-carboxylate2735714-59-5C15H11F2N3O2
- 1 suppliersEthyl 5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine-3-carboxylate1361232-72-5C16H13F2N3O2
- 4 suppliers1-((2-Fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridine-3-carboximidamide hydrochloride256499-19-1C14H13ClFN5
- 1-(2-Fluorobenzyl)-3-iodo-1H-pyrazolo(3,4-b)pyridine1313738-72-5C13H9FIN3
- 5-Bromo-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine1111638-42-6C15H14BrN3O
- 1-[1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]ethanone1137734-85-0C16H15N3O2
Related scaffolds
Same ring framework with different atoms or bond orders
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