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Murcko scaffold

Pyrazolo[1,5-a]pyrazin-4-ol scaffold

77 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
77
With full pages
11
Scaffold SMILES

O=c1[nH]ccn2nccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Pyrazolo[1,5-a]pyrazin-4-ol page
Murcko scaffold O=c1[nH]ccn2nccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 77 chemicals

2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one chemical structure, C7H7N3O, CAS 1314920-48-3
2-Methylpyrazolo[1,5-a]pyrazin-4(5H)-one
CAS 1314920-48-3C7H7N3O
2-(tert-Butyl)pyrazolo[1,5-a]pyrazin-4-ol chemical structure, C10H13N3O, CAS 1314933-28-2
2-(tert-Butyl)pyrazolo[1,5-a]pyrazin-4-ol
CAS 1314933-28-2C10H13N3O
Pyrazolo[1,5-a]pyrazin-4-ol chemical structure, C6H5N3O, CAS 1301714-00-0
Pyrazolo[1,5-a]pyrazin-4-ol
CAS 1301714-00-0C6H5N3O
2-(Trifluoromethyl)pyrazolo[1,5-A]pyrazin-4-ol chemical structure, C7H4F3N3O, CAS 877402-82-9
2-(Trifluoromethyl)pyrazolo[1,5-A]pyrazin-4-ol
CAS 877402-82-9C7H4F3N3O
Ethyl 4-Hydroxy-6-methylpyrazolo[1,5-a]pyrazine-2-carboxylate chemical structure, C10H11N3O3, CAS 1443978-76-4
Ethyl 4-Hydroxy-6-methylpyrazolo[1,5-a]pyrazine-2-carboxylate
CAS 1443978-76-4C10H11N3O3
N-(2,2-Dimethoxyethyl)-6-methyl-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamide chemical structure, C12H16N4O4, CAS 1982951-18-7
N-(2,2-Dimethoxyethyl)-6-methyl-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamide
CAS 1982951-18-7C12H16N4O4
N,6-dimethyl-N-(2-(methylamino)-2-oxoethyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamide chemical structure, C12H15N5O3, CAS 1795435-53-8
N,6-dimethyl-N-(2-(methylamino)-2-oxoethyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamide
CAS 1795435-53-8C12H15N5O3
N-(3-Isopropoxypropyl)-6-methyl-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamide chemical structure, C14H20N4O3, CAS 1798622-65-7
N-(3-Isopropoxypropyl)-6-methyl-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamide
CAS 1798622-65-7C14H20N4O3
Ethyl 3-(6-methyl-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamido)propanoate chemical structure, C13H16N4O4, CAS 1787917-76-3
Ethyl 3-(6-methyl-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamido)propanoate
CAS 1787917-76-3C13H16N4O4
3-Bromo-4H,5H-pyrazolo(1,5-a)pyrazin-4-one chemical structure, C6H4BrN3O, CAS 1784412-18-5
3-Bromo-4H,5H-pyrazolo(1,5-a)pyrazin-4-one
CAS 1784412-18-5C6H4BrN3O
5-tert-Butyl 2-ethyl 6-methyl-4-oxopyrazolo[1,5-a]pyrazine-2,5(4H)-dicarboxylate chemical structure, C15H19N3O5, CAS 1820647-45-7
5-tert-Butyl 2-ethyl 6-methyl-4-oxopyrazolo[1,5-a]pyrazine-2,5(4H)-dicarboxylate
CAS 1820647-45-7C15H19N3O5
5-(2-Aminoethyl)pyrazolo[1,5-a]pyrazin-4(5H)-one chemical structure, C8H10N4O, CAS 1566152-06-4
5-(2-Aminoethyl)pyrazolo[1,5-a]pyrazin-4(5H)-one
CAS 1566152-06-4C8H10N4O
N-(3-Methoxypropyl)-6-methyl-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamide chemical structure, C12H16N4O3, CAS 1775524-88-3
N-(3-Methoxypropyl)-6-methyl-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamide
CAS 1775524-88-3C12H16N4O3
6-Methyl-4-oxo-4H,5H-pyrazolo[1,5-a]pyrazine-2-carboxylic acid chemical structure, C8H7N3O3, CAS 1443978-44-6
6-Methyl-4-oxo-4H,5H-pyrazolo[1,5-a]pyrazine-2-carboxylic acid
CAS 1443978-44-6C8H7N3O3
2-(4-Oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetic acid chemical structure, C8H7N3O3, CAS 1564870-55-8
2-(4-Oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetic acid
CAS 1564870-55-8C8H7N3O3
2-(2-Methyl-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetic acid chemical structure, C9H9N3O3, CAS 1564622-21-4
2-(2-Methyl-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetic acid
CAS 1564622-21-4C9H9N3O3
2-(2-(tert-Butyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetic acid chemical structure, C12H15N3O3, CAS 1713461-93-8
2-(2-(tert-Butyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)acetic acid
CAS 1713461-93-8C12H15N3O3
3-(4-Oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)propanoic acid chemical structure, C9H9N3O3, CAS 1566119-40-1
3-(4-Oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)propanoic acid
CAS 1566119-40-1C9H9N3O3
5-(2-Aminoethyl)-2-methylpyrazolo[1,5-a]pyrazin-4(5H)-one chemical structure, C9H12N4O, CAS 1564941-69-0
5-(2-Aminoethyl)-2-methylpyrazolo[1,5-a]pyrazin-4(5H)-one
CAS 1564941-69-0C9H12N4O
Methyl 3-{4-oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl}propanoate chemical structure, C10H11N3O3, CAS 1564977-22-5
Methyl 3-{4-oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl}propanoate
CAS 1564977-22-5C10H11N3O3
3-{4-Oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl}propanenitrile chemical structure, C9H8N4O, CAS 1566655-23-9
3-{4-Oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl}propanenitrile
CAS 1566655-23-9C9H8N4O
3-{4-Oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl}propanamide chemical structure, C9H10N4O2, CAS 1880332-38-6
3-{4-Oxo-4H,5H-pyrazolo[1,5-a]pyrazin-5-yl}propanamide
CAS 1880332-38-6C9H10N4O2
3-(4-Oxopyrazolo[1,5-a]pyrazin-5-yl)propanehydrazide chemical structure, C9H11N5O2, CAS 1564815-44-6
3-(4-Oxopyrazolo[1,5-a]pyrazin-5-yl)propanehydrazide
CAS 1564815-44-6C9H11N5O2
6-Bromo-5H-pyrazolo[1,5-a]pyrazin-4-one chemical structure, C6H4BrN3O, CAS 1650547-56-0
6-Bromo-5H-pyrazolo[1,5-a]pyrazin-4-one
CAS 1650547-56-0C6H4BrN3O