Murcko scaffold
Ring system with 2 rings and 16 atoms
68 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 68
- With full pages
- 7
Scaffold SMILES
O=C(CNc1ccccc1)N1CCNCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 68 chemicals
![N-(2-Fluorophenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C14H20FN3O3S, CAS 6484-33-9](/s/QAPGWXFZILMPMS-UHFFFAOYSA-N.svg)
N-(2-Fluorophenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 6484-33-9C14H20FN3O3S
![N-(3,4-Dimethylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C16H25N3O3S, CAS 409356-49-6](/s/QQKFYXZBROTZTH-UHFFFAOYSA-N.svg)
N-(3,4-Dimethylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 409356-49-6C16H25N3O3S
![N-(2-Methoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C15H23N3O4S, CAS 641994-58-3](/s/VBLHKTCEEQXVBU-UHFFFAOYSA-N.svg)
N-(2-Methoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 641994-58-3C15H23N3O4S
![N-[2-(4-Ethylpiperazin-1-yl)-2-oxoethyl]-N-(3-methylphenyl)methanesulfonamide chemical structure, C16H25N3O3S, CAS 706769-86-0](/s/JGDNHIAFKZNUIY-UHFFFAOYSA-N.svg)
N-[2-(4-Ethylpiperazin-1-yl)-2-oxoethyl]-N-(3-methylphenyl)methanesulfonamide
CAS 706769-86-0C16H25N3O3S
![Ethyl 4-{[3-methoxy(methylsulfonyl)anilino]acetyl}-1-piperazinecarboxylate chemical structure, C17H25N3O6S, CAS 428480-64-2](/s/AQRJUILVJZPUEI-UHFFFAOYSA-N.svg)
Ethyl 4-{[3-methoxy(methylsulfonyl)anilino]acetyl}-1-piperazinecarboxylate
CAS 428480-64-2C17H25N3O6S
![Ethyl 4-{[4-fluoro(methylsulfonyl)anilino]acetyl}-1-piperazinecarboxylate chemical structure, C16H22FN3O5S, CAS 428466-70-0](/s/WMLSDFBKHXGBJC-UHFFFAOYSA-N.svg)
Ethyl 4-{[4-fluoro(methylsulfonyl)anilino]acetyl}-1-piperazinecarboxylate
CAS 428466-70-0C16H22FN3O5S
![N-(5-Chloro-2-methylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C15H22ClN3O3S, CAS 723738-24-7](/s/UNDJQZRPUYQIQV-UHFFFAOYSA-N.svg)
N-(5-Chloro-2-methylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 723738-24-7C15H22ClN3O3S
![Ethyl 4-{[2-chloro(methylsulfonyl)anilino]acetyl}piperazine-1-carboxylate chemical structure, C16H22ClN3O5S, CAS 333440-30-5](/s/RVNPATRGGJDPPG-UHFFFAOYSA-N.svg)
Ethyl 4-{[2-chloro(methylsulfonyl)anilino]acetyl}piperazine-1-carboxylate
CAS 333440-30-5C16H22ClN3O5S
![Ethyl 4-{[3-fluoro(methylsulfonyl)anilino]acetyl}-1-piperazinecarboxylate chemical structure, C16H22FN3O5S, CAS 573936-58-0](/s/RPXFDOKSIGUOHJ-UHFFFAOYSA-N.svg)
Ethyl 4-{[3-fluoro(methylsulfonyl)anilino]acetyl}-1-piperazinecarboxylate
CAS 573936-58-0C16H22FN3O5S
![Ethyl 4-[N-(2,3-dimethylphenyl)-N-(methanesulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C18H27N3O5S, CAS 4399-11-5](/s/UTFUJLAGBMQDHF-UHFFFAOYSA-N.svg)
Ethyl 4-[N-(2,3-dimethylphenyl)-N-(methanesulfonyl)glycyl]piperazine-1-carboxylate
CAS 4399-11-5C18H27N3O5S
![Ethyl 4-[N-(2,5-dichlorophenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C16H21Cl2N3O5S, CAS 528576-59-2](/s/UJBOFXHQRONWMA-UHFFFAOYSA-N.svg)
Ethyl 4-[N-(2,5-dichlorophenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate
CAS 528576-59-2C16H21Cl2N3O5S
![N-(3,5-Dichlorophenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C14H19Cl2N3O3S, CAS 577770-44-6](/s/GXAPDNCKCFZOBO-UHFFFAOYSA-N.svg)
N-(3,5-Dichlorophenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 577770-44-6C14H19Cl2N3O3S
![N-(2,5-Dichlorophenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C14H19Cl2N3O3S, CAS 644953-72-0](/s/NWANHPJMJDJZOZ-UHFFFAOYSA-N.svg)
N-(2,5-Dichlorophenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 644953-72-0C14H19Cl2N3O3S
![Ethyl 4-[N-(2,5-dimethylphenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C18H27N3O5S, CAS 700858-66-8](/s/DDWGTORLIGQEGQ-UHFFFAOYSA-N.svg)
Ethyl 4-[N-(2,5-dimethylphenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate
CAS 700858-66-8C18H27N3O5S
![N-[2-Chloro-5-(trifluoromethyl)phenyl]-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C16H21ClF3N3O3S, CAS 706767-27-3](/s/IWGORSLCGFVLCF-UHFFFAOYSA-N.svg)
N-[2-Chloro-5-(trifluoromethyl)phenyl]-N-[2-(4-ethylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 706767-27-3C16H21ClF3N3O3S
![Ethyl 4-[N-(4-methoxyphenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C17H25N3O6S, CAS 428449-56-3](/s/QAFPPDQNVFQNED-UHFFFAOYSA-N.svg)
Ethyl 4-[N-(4-methoxyphenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate
CAS 428449-56-3C17H25N3O6S
![Ethyl 4-[N-(2,6-dimethylphenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C18H27N3O5S, CAS 335391-56-5](/s/YBNVBGCBBNGPTJ-UHFFFAOYSA-N.svg)
Ethyl 4-[N-(2,6-dimethylphenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate
CAS 335391-56-5C18H27N3O5S
![Ethyl 4-[N-(4-chloro-2-methylphenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C17H24ClN3O5S, CAS 335391-70-3](/s/XMRSSDYQPZTWMU-UHFFFAOYSA-N.svg)
Ethyl 4-[N-(4-chloro-2-methylphenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate
CAS 335391-70-3C17H24ClN3O5S
![N-(5-Chloro-2-methoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C15H22ClN3O4S, CAS 501913-52-6](/s/ZVRVLIXMQKCXSI-UHFFFAOYSA-N.svg)
N-(5-Chloro-2-methoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 501913-52-6C15H22ClN3O4S
![N-(2-Ethoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C16H25N3O4S, CAS 333745-68-9](/s/DCGGAFXPSPXPGN-UHFFFAOYSA-N.svg)
N-(2-Ethoxyphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 333745-68-9C16H25N3O4S
![Ethyl 4-[N-(2,3-dichlorophenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate chemical structure, C16H21Cl2N3O5S, CAS 431980-99-3](/s/ZEHMQYCFRULSDT-UHFFFAOYSA-N.svg)
Ethyl 4-[N-(2,3-dichlorophenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate
CAS 431980-99-3C16H21Cl2N3O5S
![N-(2-Methoxy-5-methylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C16H25N3O4S, CAS 335394-48-4](/s/UMWCFOZLTRCPGW-UHFFFAOYSA-N.svg)
N-(2-Methoxy-5-methylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 335394-48-4C16H25N3O4S
![N-(4-Fluorophenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide chemical structure, C14H20FN3O3S, CAS 505072-17-3](/s/SFXXRGIYYFUTGD-UHFFFAOYSA-N.svg)
N-(4-Fluorophenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide
CAS 505072-17-3C14H20FN3O3S
![N-(3-Chloro-4-fluoro-phenyl)-N-[2-(4-ethylpiperazin-1-yl)-2-oxo-ethyl]methanesulfonamide chemical structure, C15H21ClFN3O3S, CAS 5474-55-5](/s/VLBQRPROHHTWAY-UHFFFAOYSA-N.svg)
N-(3-Chloro-4-fluoro-phenyl)-N-[2-(4-ethylpiperazin-1-yl)-2-oxo-ethyl]methanesulfonamide
CAS 5474-55-5C15H21ClFN3O3S
- 2-[N-(Dimethylsulfamoyl)anilino]-1-(4-methylpiperazin-1-yl)ethanone825659-34-5C15H24N4O3S
- Ethyl 4-[N-(2-methoxy-5-methylphenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate335392-32-0C18H27N3O6S
- Ethyl 4-[N-(methylsulfonyl)-N-phenylalanyl]piperazine-1-carboxylate474009-96-6C17H25N3O5S
- N-[1-(4-Methylpiperazin-1-yl)-1-oxopropan-2-yl]-N-phenylmethanesulfonamide1008594-90-8C15H23N3O3S
- Ethyl 4-[N-(4-bromo-3-methylphenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate827007-94-3C17H24BrN3O5S
- N-(3-Acetylphenyl)-N-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]methanesulfonamide827011-66-5C16H23N3O4S
- N-[2-(4-Ethylpiperazin-1-yl)-2-oxoethyl]-N-(2-methoxy-5-nitrophenyl)methanesulfonamide836663-46-8C16H24N4O6S
- Ethyl 4-[N-(2,4-dichlorophenyl)-N-(methylsulfonyl)glycyl]piperazine-1-carboxylate838811-42-0C16H21Cl2N3O5S
- Piperazine, 1-methyl-4-(((3,4,5-trimethoxyphenyl)amino)acetyl)-68061-24-5C16H25N3O4
- N-(3-Chlorophenyl)-N-[1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]methanesulfonamide1008713-90-3C15H22ClN3O3S
- N-(4-Fluorophenyl)-N-[1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]methanesulfonamide1040555-68-7C15H22FN3O3S
- 1-(4-Methyl-1-piperazinyl)-2-(phenylamino)-1-propanone70060-40-1C14H21N3O
- N-(3,4-Dimethylphenyl)-N-[1-(4-methylpiperazin-1-yl)-1-oxobutan-2-yl]methanesulfonamide1094480-07-5C18H29N3O3S
- {(4-Methoxyphenyl)[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino}acetic acid1142205-29-5C16H23N3O4
- [[2-(4-Ethylpiperazin-1-yl)-2-oxoethyl]-(4-methoxyphenyl)amino]acetic acid1142205-31-9C17H25N3O4
- [{2-[4-(Ethoxycarbonyl)piperazin-1-yl]-2-oxoethyl}(4-methoxyphenyl)amino]acetic acid1142205-34-2C18H25N3O6
- [{2-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-oxoethyl}(4-methoxyphenyl)amino]acetic acid1142205-45-5C17H25N3O5
- [[2-(4-Acetylpiperazin-1-yl)-2-oxoethyl]-(4-methoxyphenyl)amino]acetic acid1142205-48-8C17H23N3O5
- [{2-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-2-oxoethyl}(4-methoxyphenyl)amino]acetic acid1142205-70-6C20H29N3O6
- [[2-(4-Methylpiperazin-1-yl)-2-oxoethyl](phenyl)-amino]acetic acid1142205-97-7C15H21N3O3
- [[2-(4-Ethylpiperazin-1-yl)-2-oxoethyl](phenyl)-amino]acetic acid1142205-98-8C16H23N3O3
- [{2-[4-(Ethoxycarbonyl)piperazin-1-yl]-2-oxoethyl}(phenyl)amino]acetic acid1142206-00-5C17H23N3O5
- [{2-[4-(2-Hydroxyethyl)piperazin-1-yl]-2-oxoethyl}(phenyl)amino]acetic acid1142211-58-2C16H23N3O4
- [[2-(4-Acetylpiperazin-1-yl)-2-oxoethyl](phenyl)-amino]acetic acid1142211-64-0C16H21N3O4
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)Nc1ccccc1421 chemicals
O=C(C=Cc1ccccc1)c1ccccc1389 chemicals
O=C(NCc1ccccc1)c1ccccc1260 chemicals
O=C(Cc1ccccc1)Nc1ccccc1219 chemicals
O=S(=O)(NCc1ccccc1)c1ccccc1164 chemicals
c1ccc(CNCc2ccccc2)cc1142 chemicals
S=C(Nc1ccccc1)Nc1ccccc1109 chemicals
O=C(CCc1ccccc1)c1ccccc187 chemicals
C(=NNc1ccccc1)c1ccccc173 chemicals
O=C(Nc1ccccc1)Oc1ccccc173 chemicals
O=C(OCc1ccccc1)N1CCCCC161 chemicals
O=C(OCc1ccccc1)c1ccccc157 chemicals