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Murcko scaffold

1-Phenylpiperazin-2-one scaffold

157 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 13
Chemicals: 157
With full pages: 9

Scaffold SMILES

O=C1CNCCN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 1-Phenylpiperazin-2-one page

Murcko scaffold O=C1CNCCN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 157 chemicals

1-(3-Bromo-phenyl)-piperazin-2-one chemical structure, C10H11BrN2O, CAS 749833-17-8

1-(3-Bromo-phenyl)-piperazin-2-one

CAS 749833-17-8C₁₀H₁₁BrN₂O

1-(2-Methoxy-phenyl)-piperazin-2-one chemical structure, C11H14N2O2, CAS 95520-94-8

1-(2-Methoxy-phenyl)-piperazin-2-one

CAS 95520-94-8C₁₁H₁₄N₂O₂

1-(2,4-Dimethyl-phenyl)-piperazin-2-one chemical structure, C12H16N2O, CAS 907972-47-8

1-(2,4-Dimethyl-phenyl)-piperazin-2-one

CAS 907972-47-8C₁₂H₁₆N₂O

1-(2-Methoxyphenyl)-3-methylpiperazin-2-one chemical structure, C12H16N2O2, CAS 1009675-99-3

1-(2-Methoxyphenyl)-3-methylpiperazin-2-one

CAS 1009675-99-3C₁₂H₁₆N₂O₂

1-(3-Chlorophenyl)piperazin-2-one hydrochloride chemical structure, C10H12Cl2N2O, CAS 183500-94-9

1-(3-Chlorophenyl)piperazin-2-one hydrochloride

CAS 183500-94-9C₁₀H₁₂Cl₂N₂O

1-(3-Chlorophenyl)piperazin-2-one chemical structure, C10H11ClN2O, CAS 183500-70-1

1-(3-Chlorophenyl)piperazin-2-one

CAS 183500-70-1C₁₀H₁₁ClN₂O

1-(3-Chlorophenyl)-3-methylpiperazin-2-one chemical structure, C11H13ClN2O, CAS 151447-78-8

1-(3-Chlorophenyl)-3-methylpiperazin-2-one

CAS 151447-78-8C₁₁H₁₃ClN₂O

1-(3,5-Difluoro-phenyl)-piperazin-2-one chemical structure, C10H10F2N2O, CAS 475653-36-2

1-(3,5-Difluoro-phenyl)-piperazin-2-one

CAS 475653-36-2C₁₀H₁₀F₂N₂O

1-(3-Nitrophenyl)piperazin-2-one chemical structure, C10H11N3O3, CAS 215649-84-6

1-(3-Nitrophenyl)piperazin-2-one

CAS 215649-84-6C₁₀H₁₁N₃O₃

3-Methyl-1-phenylpiperazin-2-one chemical structure, C11H14N2O, CAS 72615-77-1

3-Methyl-1-phenylpiperazin-2-one

CAS 72615-77-1C₁₁H₁₄N₂O

3,3,5,5-Tetramethyl-1-phenyl-2-piperazinone chemical structure, C14H20N2O, CAS 71620-94-5

3,3,5,5-Tetramethyl-1-phenyl-2-piperazinone

CAS 71620-94-5C₁₄H₂₀N₂O

1-(2,6-Dimethylphenyl)piperazin-2-one chemical structure, C12H16N2O, CAS 75889-29-1

1-(2,6-Dimethylphenyl)piperazin-2-one

CAS 75889-29-1C₁₂H₁₆N₂O

3-Butyl-3,5,5-trimethyl-1-phenylpiperazin-2-one chemical structure, C17H26N2O, CAS 90016-97-0

3-Butyl-3,5,5-trimethyl-1-phenylpiperazin-2-one

CAS 90016-97-0C₁₇H₂₆N₂O

3-Butyl-4-hydroxy-3,5,5-trimethyl-1-phenylpiperazin-2-one chemical structure, C17H26N2O2, CAS 90017-00-8

3-Butyl-4-hydroxy-3,5,5-trimethyl-1-phenylpiperazin-2-one

CAS 90017-00-8C₁₇H₂₆N₂O₂

1-Phenylpiperazin-2-one chemical structure, C10H12N2O, CAS 90917-86-5

1-Phenylpiperazin-2-one

CAS 90917-86-5C₁₀H₁₂N₂O

1-(4-Chlorophenyl)piperazin-2-one chemical structure, C10H11ClN2O, CAS 55083-85-7

1-(4-Chlorophenyl)piperazin-2-one

CAS 55083-85-7C₁₀H₁₁ClN₂O

1-(2-Chlorophenyl)piperazin-2-one chemical structure, C10H11ClN2O, CAS 197967-66-1

1-(2-Chlorophenyl)piperazin-2-one

CAS 197967-66-1C₁₀H₁₁ClN₂O

1-(3-(Trifluoromethoxy)phenyl)piperazin-2-one chemical structure, C11H11F3N2O2, CAS 215649-79-9

1-(3-(Trifluoromethoxy)phenyl)piperazin-2-one

CAS 215649-79-9C₁₁H₁₁F₃N₂O₂

1-(3-Methoxyphenyl)piperazin-2-one chemical structure, C11H14N2O2, CAS 215649-80-2

1-(3-Methoxyphenyl)piperazin-2-one

CAS 215649-80-2C₁₁H₁₄N₂O₂

1-(4-Methoxyphenyl)piperazin-2-one chemical structure, C11H14N2O2, CAS 215649-82-4

1-(4-Methoxyphenyl)piperazin-2-one

CAS 215649-82-4C₁₁H₁₄N₂O₂

1-(4-(Trifluoromethyl)phenyl)piperazin-2-one chemical structure, C11H11F3N2O, CAS 769108-97-6

1-(4-(Trifluoromethyl)phenyl)piperazin-2-one

CAS 769108-97-6C₁₁H₁₁F₃N₂O

1-Phenylpiperazin-2-one hydrochloride chemical structure, C10H13ClN2O, CAS 94783-18-3

1-Phenylpiperazin-2-one hydrochloride

CAS 94783-18-3C₁₀H₁₃ClN₂O

1-(4-Fluorophenyl)piperazin-2-one chemical structure, C10H11FN2O, CAS 780753-89-1

1-(4-Fluorophenyl)piperazin-2-one

CAS 780753-89-1C₁₀H₁₁FN₂O

1-(3-Methylphenyl)piperazin-2-one chemical structure, C11H14N2O, CAS 893748-27-1

1-(3-Methylphenyl)piperazin-2-one

CAS 893748-27-1C₁₁H₁₄N₂O