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Murcko scaffold

Ring system with 3 rings and 22 atoms

347 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
347
With full pages
41
Scaffold SMILES

O=C1NC=C(C(=O)Nc2ccccc2)C(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC=C(C(=O)Nc2ccccc2)C(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 347 chemicals

N-(2,3-Dimethylphenyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3O3, CAS 361182-47-0
N-(2,3-Dimethylphenyl)-4-(3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 361182-47-0C21H23N3O3
N-(2,3-Dimethylphenyl)-6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C23H27N3O5, CAS 374601-49-7
N-(2,3-Dimethylphenyl)-6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 374601-49-7C23H27N3O5
4-(4-Fluorophenyl)-6-methyl-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H16FN3O2, CAS 333768-16-4
4-(4-Fluorophenyl)-6-methyl-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 333768-16-4C18H16FN3O2
4-(2-Fluorophenyl)-6-methyl-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H16FN3O2, CAS 299418-73-8
4-(2-Fluorophenyl)-6-methyl-2-oxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 299418-73-8C18H16FN3O2
N-(4-Bromophenyl)-4-{4-nitrophenyl}-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H15BrN4O4, CAS 331272-61-8
N-(4-Bromophenyl)-4-{4-nitrophenyl}-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 331272-61-8C18H15BrN4O4
4-(2,4-Dichlorophenyl)-6-methyl-2-oxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H17Cl2N3O2, CAS 313970-21-7
4-(2,4-Dichlorophenyl)-6-methyl-2-oxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 313970-21-7C19H17Cl2N3O2
4-(5-Bromo-2-hydroxyphenyl)-6-methyl-N-(4-methylphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C19H18BrN3O3, CAS 352640-44-9
4-(5-Bromo-2-hydroxyphenyl)-6-methyl-N-(4-methylphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 352640-44-9C19H18BrN3O3
4-(4-Methoxyphenyl)-1,6-dimethyl-N-(2-methylphenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C21H23N3O3, CAS 352640-43-8
4-(4-Methoxyphenyl)-1,6-dimethyl-N-(2-methylphenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide
CAS 352640-43-8C21H23N3O3
4-[4-(Dimethylamino)phenyl]-6-methyl-N-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H24N4O2, CAS 331676-13-2
4-[4-(Dimethylamino)phenyl]-6-methyl-N-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 331676-13-2C21H24N4O2
4-(3,4-Dimethoxyphenyl)-6-methyl-2-oxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3O4, CAS 328556-96-3
4-(3,4-Dimethoxyphenyl)-6-methyl-2-oxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 328556-96-3C21H23N3O4
6-Methyl-N-(2-methylphenyl)-2-oxo-4-(2,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C22H25N3O5, CAS 5568-82-1
6-Methyl-N-(2-methylphenyl)-2-oxo-4-(2,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 5568-82-1C22H25N3O5
N-(4-Bromophenyl)-6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H22BrN3O5, CAS 331870-23-6
N-(4-Bromophenyl)-6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 331870-23-6C21H22BrN3O5
N,4-bis(4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H15Cl2N3O2, CAS 330453-62-8
N,4-bis(4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 330453-62-8C18H15Cl2N3O2
N-(4-Chlorophenyl)-4-(2,5-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C20H20ClN3O4, CAS 312735-16-3
N-(4-Chlorophenyl)-4-(2,5-dimethoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 312735-16-3C20H20ClN3O4
4-(4-Chlorophenyl)-6-methyl-2-oxo-N-phenyl-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H16ClN3O2, CAS 419546-39-7
4-(4-Chlorophenyl)-6-methyl-2-oxo-N-phenyl-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 419546-39-7C18H16ClN3O2
4-(3-Bromophenyl)-N-(4-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H15Br2N3O2, CAS 330453-76-4
4-(3-Bromophenyl)-N-(4-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 330453-76-4C18H15Br2N3O2
N-(4-Chlorophenyl)-6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C21H22ClN3O5, CAS 328557-07-9
N-(4-Chlorophenyl)-6-methyl-2-oxo-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 328557-07-9C21H22ClN3O5
4-(3-Bromophenyl)-1,2,3,4-tetrahydro-6-methyl-N-(4-methylphenyl)-2-oxo-5-pyrimidinecarboxamide chemical structure, C19H18BrN3O2, CAS 419547-12-9
4-(3-Bromophenyl)-1,2,3,4-tetrahydro-6-methyl-N-(4-methylphenyl)-2-oxo-5-pyrimidinecarboxamide
CAS 419547-12-9C19H18BrN3O2
4-(3-Bromophenyl)-6-methyl-2-oxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H18BrN3O2, CAS 330453-73-1
4-(3-Bromophenyl)-6-methyl-2-oxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 330453-73-1C19H18BrN3O2
N-(4-Chlorophenyl)-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C18H16ClN3O2, CAS 330453-93-5
N-(4-Chlorophenyl)-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 330453-93-5C18H16ClN3O2
4-(4-Chlorophenyl)-6-methyl-N-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H18ClN3O2, CAS 330453-67-3
4-(4-Chlorophenyl)-6-methyl-N-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 330453-67-3C19H18ClN3O2
N-(4-Chlorophenyl)-4-(4-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C19H18ClN3O3, CAS 328556-98-5
N-(4-Chlorophenyl)-4-(4-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 328556-98-5C19H18ClN3O3
4-(4-Chlorophenyl)-6-methyl-N-(2-methylphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C19H18ClN3O2, CAS 5678-81-9
4-(4-Chlorophenyl)-6-methyl-N-(2-methylphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 5678-81-9C19H18ClN3O2
N-(4-Bromophenyl)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H15BrClN3O2, CAS 5680-52-4
N-(4-Bromophenyl)-4-(4-chlorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 5680-52-4C18H15BrClN3O2