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Murcko scaffold

Ring system with 3 rings and 22 atoms

376 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
376
With full pages
5
Scaffold SMILES

O=C(Nc1ccccc1)C1=CNC(=S)NC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)C1=CNC(=S)NC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 376 chemicals

4-(4-Chlorophenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C18H16ClN3OS, CAS 182170-95-2
4-(4-Chlorophenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide
CAS 182170-95-2C18H16ClN3OS
4-(2-Chloro-6-fluorophenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C18H15ClFN3OS, CAS 183231-05-2
4-(2-Chloro-6-fluorophenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide
CAS 183231-05-2C18H15ClFN3OS
4-(4-Fluorophenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C18H16FN3OS, CAS 299421-90-2
4-(4-Fluorophenyl)-6-methyl-N-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide
CAS 299421-90-2C18H16FN3OS
4-(4-Chlorophenyl)-N-(2,4-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C18H14Cl3N3OS, CAS 303985-85-5
4-(4-Chlorophenyl)-N-(2,4-dichlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide
CAS 303985-85-5C18H14Cl3N3OS
4-Methyl-N,6-diphenyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxamide chemical structure, C18H17N3OS, CAS 182170-90-7
4-Methyl-N,6-diphenyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxamide
CAS 182170-90-7C18H17N3OS
4-(4-Bromophenyl)-6-methyl-N-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H16BrN3OS, CAS 313533-47-0
4-(4-Bromophenyl)-6-methyl-N-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 313533-47-0C18H16BrN3OS
N-(4-Bromophenyl)-4-{4-nitrophenyl}-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C18H15BrN4O3S, CAS 331272-60-7
N-(4-Bromophenyl)-4-{4-nitrophenyl}-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide
CAS 331272-60-7C18H15BrN4O3S
N-(4-Bromophenyl)-4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H18BrN3O3S, CAS 416877-72-0
N-(4-Bromophenyl)-4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 416877-72-0C19H18BrN3O3S
N-(4-Bromophenyl)-4-(2,4-dichlorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C18H14BrCl2N3OS, CAS 313392-22-2
N-(4-Bromophenyl)-4-(2,4-dichlorophenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 313392-22-2C18H14BrCl2N3OS
N-(4-Bromophenyl)-4-(2,5-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C20H20BrN3O3S, CAS 331272-49-2
N-(4-Bromophenyl)-4-(2,5-dimethoxyphenyl)-6-methyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 331272-49-2C20H20BrN3O3S
4-(2,4-Dichlorophenyl)-6-methyl-2-thioxo-N-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H17Cl2N3OS, CAS 314052-38-5
4-(2,4-Dichlorophenyl)-6-methyl-2-thioxo-N-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 314052-38-5C19H17Cl2N3OS
4-(5-Bromo-2-hydroxyphenyl)-6-methyl-N-(4-methylphenyl)-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C19H18BrN3O2S, CAS 331676-02-9
4-(5-Bromo-2-hydroxyphenyl)-6-methyl-N-(4-methylphenyl)-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide
CAS 331676-02-9C19H18BrN3O2S
6-Methyl-N-(2-methylphenyl)-2-sulfanylidene-4-(2,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C22H25N3O4S, CAS 313398-07-1
6-Methyl-N-(2-methylphenyl)-2-sulfanylidene-4-(2,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 313398-07-1C22H25N3O4S
4-(2,3-Dimethoxyphenyl)-6-methyl-2-thioxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C21H23N3O3S, CAS 312735-11-8
4-(2,3-Dimethoxyphenyl)-6-methyl-2-thioxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 312735-11-8C21H23N3O3S
6-Methyl-4-phenyl-2-thioxo-N-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H19N3OS, CAS 313956-77-3
6-Methyl-4-phenyl-2-thioxo-N-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 313956-77-3C19H19N3OS
4-(4-Bromophenyl)-6-methyl-2-thioxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H18BrN3OS, CAS 326919-78-2
4-(4-Bromophenyl)-6-methyl-2-thioxo-N-(o-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 326919-78-2C19H18BrN3OS
4-(4-Hydroxyphenyl)-6-methyl-2-thioxo-N-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide chemical structure, C19H19N3O2S, CAS 331676-00-7
4-(4-Hydroxyphenyl)-6-methyl-2-thioxo-N-(p-tolyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS 331676-00-7C19H19N3O2S
4-(2-Hydroxyphenyl)-6-methyl-N-(2-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C19H19N3O2S, CAS 331675-87-7
4-(2-Hydroxyphenyl)-6-methyl-N-(2-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 331675-87-7C19H19N3O2S
4-[4-(Dimethylamino)phenyl]-6-methyl-N-(2-methylphenyl)-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide chemical structure, C21H24N4OS, CAS 328556-95-2
4-[4-(Dimethylamino)phenyl]-6-methyl-N-(2-methylphenyl)-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxamide
CAS 328556-95-2C21H24N4OS
6-Methyl-N-(3-methylphenyl)-2-sulfanylidene-4-(2,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C22H25N3O4S, CAS 331676-29-0
6-Methyl-N-(3-methylphenyl)-2-sulfanylidene-4-(2,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 331676-29-0C22H25N3O4S
4-(2,5-Dimethoxyphenyl)-6-methyl-N-(2-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C21H23N3O3S, CAS 312735-06-1
4-(2,5-Dimethoxyphenyl)-6-methyl-N-(2-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 312735-06-1C21H23N3O3S
4-(2,3-Dimethoxyphenyl)-6-methyl-N-(3-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C21H23N3O3S, CAS 331676-28-9
4-(2,3-Dimethoxyphenyl)-6-methyl-N-(3-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 331676-28-9C21H23N3O3S
4-(2,5-Dimethoxyphenyl)-6-methyl-N-(4-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C21H23N3O3S, CAS 331676-04-1
4-(2,5-Dimethoxyphenyl)-6-methyl-N-(4-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 331676-04-1C21H23N3O3S
4-(3,4-Dimethoxyphenyl)-6-methyl-N-(4-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide chemical structure, C21H23N3O3S, CAS 331676-16-5
4-(3,4-Dimethoxyphenyl)-6-methyl-N-(4-methylphenyl)-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxamide
CAS 331676-16-5C21H23N3O3S