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Murcko scaffold

1,2,3,4-Tetrahydropyrrolo(1,2-a)pyrazine scaffold

177 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
177
With full pages
19
Scaffold SMILES

c1cc2n(c1)CCNC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,2,3,4-Tetrahydropyrrolo(1,2-a)pyrazine page
Murcko scaffold c1cc2n(c1)CCNC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 177 chemicals

1,2,3,4-Tetrahydropyrrolo(1,2-a)pyrazine chemical structure, C7H10N2, CAS 71257-38-0
1,2,3,4-Tetrahydropyrrolo(1,2-a)pyrazine
CAS 71257-38-0C7H10N2
(1S)-1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C8H12N2, CAS 2740344-17-4
(1S)-1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 2740344-17-4C8H12N2
(1R)-1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C8H12N2, CAS 1308271-30-8
(1R)-1-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 1308271-30-8C8H12N2
1-Propyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C10H16N2, CAS 112758-86-8
1-Propyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 112758-86-8C10H16N2
1-Isopropyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C10H16N2, CAS 876721-10-7
1-Isopropyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 876721-10-7C10H16N2
1-Ethyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C9H14N2, CAS 118959-62-9
1-Ethyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 118959-62-9C9H14N2
1-Ethyl-6-methyl-1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine chemical structure, C10H16N2, CAS 876715-62-7
1-Ethyl-6-methyl-1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine
CAS 876715-62-7C10H16N2
1-Methyl-1H,2H,3H,4H-pyrrolo(1,2-a)pyrazine chemical structure, C8H12N2, CAS 73627-18-6
1-Methyl-1H,2H,3H,4H-pyrrolo(1,2-a)pyrazine
CAS 73627-18-6C8H12N2
2-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C8H12N2, CAS 681447-26-7
2-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 681447-26-7C8H12N2
1,6-Dimethyl-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine chemical structure, C9H14N2, CAS 815632-27-0
1,6-Dimethyl-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine
CAS 815632-27-0C9H14N2
1,2,3,4-Tetrahydro-1,2-dimethylpyrrolo[1,2-a]pyrazine chemical structure, C9H14N2, CAS 73627-19-7
1,2,3,4-Tetrahydro-1,2-dimethylpyrrolo[1,2-a]pyrazine
CAS 73627-19-7C9H14N2
1-Isopropyl-6-methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C11H18N2, CAS 878669-96-6
1-Isopropyl-6-methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 878669-96-6C11H18N2
6-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C8H12N2, CAS 112758-85-7
6-Methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 112758-85-7C8H12N2
2-(3,4-Dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)acetonitrile chemical structure, C9H11N3, CAS 478552-91-9
2-(3,4-Dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)acetonitrile
CAS 478552-91-9C9H11N3
1-(3,4-Dihydropyrrolo[1,2-A]pyrazin-2(1H)-YL)propan-2-ol chemical structure, C10H16N2O, CAS 620958-69-2
1-(3,4-Dihydropyrrolo[1,2-A]pyrazin-2(1H)-YL)propan-2-ol
CAS 620958-69-2C10H16N2O
1-(3,4-Dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethanone chemical structure, C9H12N2O, CAS 165117-99-7
1-(3,4-Dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethanone
CAS 165117-99-7C9H12N2O
6-Chloro-1-methyl-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine chemical structure, C8H11ClN2, CAS 930395-99-6
6-Chloro-1-methyl-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine
CAS 930395-99-6C8H11ClN2
1-Butyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C11H18N2, CAS 1146299-07-1
1-Butyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 1146299-07-1C11H18N2
2-(tert-Butoxycarbonyl)-8-(methoxycarbonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxylic acid chemical structure, C15H20N2O6, CAS 1108698-39-0
2-(tert-Butoxycarbonyl)-8-(methoxycarbonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxylic acid
CAS 1108698-39-0C15H20N2O6
6-(Trifluoromethyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C8H9F3N2, CAS 1020717-79-6
6-(Trifluoromethyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 1020717-79-6C8H9F3N2
1,1-Dimethyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine chemical structure, C9H14N2, CAS 1215295-90-1
1,1-Dimethyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine
CAS 1215295-90-1C9H14N2
tert-Butyl 1-methyl-6-(methylcarbamoyl)-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine-2-carboxylate chemical structure, C15H23N3O3, CAS 1087784-18-6
tert-Butyl 1-methyl-6-(methylcarbamoyl)-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine-2-carboxylate
CAS 1087784-18-6C15H23N3O3
tert-Butyl 6-cyano-1-methyl-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine-2-carboxylate chemical structure, C14H19N3O2, CAS 1050884-26-8
tert-Butyl 6-cyano-1-methyl-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine-2-carboxylate
CAS 1050884-26-8C14H19N3O2
1-Methyl-N-(propan-2-yl)-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine-6-carboxamide chemical structure, C12H19N3O, CAS 1087792-06-0
1-Methyl-N-(propan-2-yl)-1H,2H,3H,4H-pyrrolo[1,2-a]pyrazine-6-carboxamide
CAS 1087792-06-0C12H19N3O