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Murcko scaffold

Ring system with 4 rings and 26 atoms

41 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
41
With full pages
23
Scaffold SMILES

O=C(C1=CC(=O)N(Cc2cccnc2)C1c1ccccc1)c1ccco1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(Cc2cccnc2)C1c1ccccc1)c1ccco1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

5-(4-Ethoxy-3-methoxy-phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-pyridin-3-ylmethyl-1,5-dihydro-pyrrol-2-one chemical structure, C24H22N2O6, CAS 442149-93-1
5-(4-Ethoxy-3-methoxy-phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-pyridin-3-ylmethyl-1,5-dihydro-pyrrol-2-one
CAS 442149-93-1C24H22N2O6
4-(Furan-2-carbonyl)-3-hydroxy-5-(4-isopropoxyphenyl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one chemical structure, C24H22N2O5, CAS 636991-74-7
4-(Furan-2-carbonyl)-3-hydroxy-5-(4-isopropoxyphenyl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one
CAS 636991-74-7C24H22N2O5
4-(2-Furoyl)-3-hydroxy-5-(4-methoxyphenyl)-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H18N2O5, CAS 381169-34-2
4-(2-Furoyl)-3-hydroxy-5-(4-methoxyphenyl)-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 381169-34-2C22H18N2O5
5-(4-CL-PH)-4-(2-Furoyl)-3-HO-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H15ClN2O4, CAS 380906-28-5
5-(4-CL-PH)-4-(2-Furoyl)-3-HO-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 380906-28-5C21H15ClN2O4
4-(2-Furoyl)-3-HO-5-(3-nitro-PH)-1-(3-pyridinyl-ME)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H15N3O6, CAS 380567-65-7
4-(2-Furoyl)-3-HO-5-(3-nitro-PH)-1-(3-pyridinyl-ME)-1,5-dihydro-2H-pyrrol-2-one
CAS 380567-65-7C21H15N3O6
5-(2-Fluoro-phenyl)-3-hydroxy-4-(5-methyl-furan-2-carbonyl)-1-pyridin-3-ylmethyl-1,5-dihydro-pyrrol-2-one chemical structure, C22H17FN2O4, CAS 371225-56-8
5-(2-Fluoro-phenyl)-3-hydroxy-4-(5-methyl-furan-2-carbonyl)-1-pyridin-3-ylmethyl-1,5-dihydro-pyrrol-2-one
CAS 371225-56-8C22H17FN2O4
5-(4-Bromophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H17BrN2O4, CAS 371926-77-1
5-(4-Bromophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 371926-77-1C22H17BrN2O4
5-(4-tert-Butylphenyl)-4-(2-furoyl)-3-hydroxy-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H24N2O4, CAS 431932-64-8
5-(4-tert-Butylphenyl)-4-(2-furoyl)-3-hydroxy-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 431932-64-8C25H24N2O4
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H24N2O6, CAS 371234-40-1
5-(4-Ethoxy-3-methoxyphenyl)-3-hydroxy-4-(5-methylfuran-2-carbonyl)-1-[(pyridin-3-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 371234-40-1C25H24N2O6
(4E)-5-(4-Chlorophenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C22H17ClN2O4, CAS 371929-57-6
(4E)-5-(4-Chlorophenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 371929-57-6C22H17ClN2O4
5-(3,4-Dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one chemical structure, C23H20N2O6, CAS 432013-33-7
5-(3,4-Dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one
CAS 432013-33-7C23H20N2O6
3-Hydroxy-4-(5-methyl-2-furoyl)-5-(3-nitrophenyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H17N3O6, CAS 432015-22-0
3-Hydroxy-4-(5-methyl-2-furoyl)-5-(3-nitrophenyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 432015-22-0C22H17N3O6
(4E)-5-(3,4-Dichlorophenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C22H16Cl2N2O4, CAS 371130-23-3
(4E)-5-(3,4-Dichlorophenyl)-4-[hydroxy(5-methylfuran-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 371130-23-3C22H16Cl2N2O4
2-(4-Fluorophenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(pyridin-3-ylmethyl)-2H-pyrrol-5-one chemical structure, C22H17FN2O4, CAS 371924-49-1
2-(4-Fluorophenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(pyridin-3-ylmethyl)-2H-pyrrol-5-one
CAS 371924-49-1C22H17FN2O4
4-(2-Furylcarbonyl)-3-hydroxy-1-(3-pyridylmethyl)-5-(3,4,5-trimethoxyphenyl)-3-pyrrolin-2-one chemical structure, C24H22N2O7, CAS 369400-85-1
4-(2-Furylcarbonyl)-3-hydroxy-1-(3-pyridylmethyl)-5-(3,4,5-trimethoxyphenyl)-3-pyrrolin-2-one
CAS 369400-85-1C24H22N2O7
(4E)-5-(4-Ethoxyphenyl)-4-[furan-2-yl(hydroxy)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C23H20N2O5, CAS 371137-91-6
(4E)-5-(4-Ethoxyphenyl)-4-[furan-2-yl(hydroxy)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 371137-91-6C23H20N2O5
4-Hydroxy-3-(5-methylfuran-2-carbonyl)-1-(pyridin-3-ylmethyl)-2-(3,4,5-trimethoxyphenyl)-2H-pyrrol-5-one chemical structure, C25H24N2O7, CAS 433326-44-4
4-Hydroxy-3-(5-methylfuran-2-carbonyl)-1-(pyridin-3-ylmethyl)-2-(3,4,5-trimethoxyphenyl)-2H-pyrrol-5-one
CAS 433326-44-4C25H24N2O7
3-Hydroxy-4-[(5-methyl(2-furyl))carbonyl]-5-(4-propoxyphenyl)-1-(3-pyridylmeth yl)-3-pyrrolin-2-one chemical structure, C25H24N2O5, CAS 638134-03-9
3-Hydroxy-4-[(5-methyl(2-furyl))carbonyl]-5-(4-propoxyphenyl)-1-(3-pyridylmeth yl)-3-pyrrolin-2-one
CAS 638134-03-9C25H24N2O5
5-(2,5-Dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one chemical structure, C23H20N2O6, CAS 638134-27-7
5-(2,5-Dimethoxyphenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one
CAS 638134-27-7C23H20N2O6
3-Hydroxy-5-(4-isopropoxyphenyl)-4-(5-methylfuran-2-carbonyl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one chemical structure, C25H24N2O5, CAS 614748-10-6
3-Hydroxy-5-(4-isopropoxyphenyl)-4-(5-methylfuran-2-carbonyl)-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one
CAS 614748-10-6C25H24N2O5
4-(Furan-2-carbonyl)-3-hydroxy-5-phenyl-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one chemical structure, C21H16N2O4, CAS 378763-90-7
4-(Furan-2-carbonyl)-3-hydroxy-5-phenyl-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one
CAS 378763-90-7C21H16N2O4
5-[4-(Dimethylamino)phenyl]-4-(furan-2-ylcarbonyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H21N3O4, CAS 371140-92-0
5-[4-(Dimethylamino)phenyl]-4-(furan-2-ylcarbonyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 371140-92-0C23H21N3O4
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-5-(4-hydroxy-3-methoxyphenyl)-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C22H18N2O6, CAS 371236-95-2
(4E)-4-[Furan-2-yl(hydroxy)methylidene]-5-(4-hydroxy-3-methoxyphenyl)-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 371236-95-2C22H18N2O6
3-Hydroxy-4-(5-methyl-2-furoyl)-5-(4-methylphenyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H20N2O4, CAS 439947-69-0
3-Hydroxy-4-(5-methyl-2-furoyl)-5-(4-methylphenyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 439947-69-0C23H20N2O4