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Murcko scaffold

Ring system with 4 rings and 26 atoms

215 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
215
With full pages
21
Scaffold SMILES

O=C1C(=O)N(Cc2ccco2)C(c2ccccc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)N(Cc2ccco2)C(c2ccccc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 215 chemicals

4-(4-Chlorobenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C22H15ClN2O6
4-(4-Chlorobenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one
C22H15ClN2O6
1-(Furan-2-ylmethyl)-3-hydroxy-4-(4-methoxybenzoyl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C23H18N2O7, CAS 489397-64-0
1-(Furan-2-ylmethyl)-3-hydroxy-4-(4-methoxybenzoyl)-5-(3-nitrophenyl)-1H-pyrrol-2(5H)-one
CAS 489397-64-0C23H18N2O7
5-(3,4-Dimethoxyphenyl)-1-[(furan-2-yl)methyl]-3-hydroxy-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H23NO7, CAS 609314-42-3
5-(3,4-Dimethoxyphenyl)-1-[(furan-2-yl)methyl]-3-hydroxy-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 609314-42-3C25H23NO7
1-[(Furan-2-yl)methyl]-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H21NO7, CAS 609314-44-5
1-[(Furan-2-yl)methyl]-3-hydroxy-5-(4-hydroxy-3-methoxyphenyl)-4-(3-methoxybenzoyl)-2,5-dihydro-1H-pyrrol-2-one
CAS 609314-44-5C24H21NO7
5-(4-Ethoxyphenyl)-4-(3-fluoro-4-methoxybenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C25H22FNO6
5-(4-Ethoxyphenyl)-4-(3-fluoro-4-methoxybenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-1H-pyrrol-2(5H)-one
C25H22FNO6
4-(3-Fluoro-4-methylbenzoyl)-5-(2-fluorophenyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H17F2NO4
4-(3-Fluoro-4-methylbenzoyl)-5-(2-fluorophenyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C23H17F2NO4
1-[(Furan-2-yl)methyl]-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H27NO5
1-[(Furan-2-yl)methyl]-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one
C28H27NO5
4-(3-Fluoro-4-methylbenzoyl)-5-(4-fluorophenyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H17F2NO4
4-(3-Fluoro-4-methylbenzoyl)-5-(4-fluorophenyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C23H17F2NO4
4-(3-Fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H20FNO5
4-(3-Fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-5-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one
C24H20FNO5
5-(4-Butoxyphenyl)-4-(4-chlorobenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H24ClNO5
5-(4-Butoxyphenyl)-4-(4-chlorobenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C26H24ClNO5
4-(4-Chlorobenzoyl)-5-(3,4-dimethoxyphenyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H20ClNO6
4-(4-Chlorobenzoyl)-5-(3,4-dimethoxyphenyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C24H20ClNO6
1-[(Furan-2-yl)methyl]-3-hydroxy-5-(4-methylphenyl)-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H23NO5
1-[(Furan-2-yl)methyl]-3-hydroxy-5-(4-methylphenyl)-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C26H23NO5
5-(4-Bromophenyl)-4-(4-ethoxybenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H20BrNO5
5-(4-Bromophenyl)-4-(4-ethoxybenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C24H20BrNO5
5-(3,4-Dimethoxyphenyl)-4-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H22FNO6
5-(3,4-Dimethoxyphenyl)-4-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C25H22FNO6
4-(3-Fluoro-4-methylbenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one chemical structure, C23H17FN2O6, CAS 618074-00-3
4-(3-Fluoro-4-methylbenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-5-(4-nitrophenyl)-1H-pyrrol-2(5H)-one
CAS 618074-00-3C23H17FN2O6
Methyl 4-[3-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-2-yl]benzoate chemical structure, C25H20FNO6
Methyl 4-[3-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-2-yl]benzoate
C25H20FNO6
5-(3,4-Dimethoxyphenyl)-4-(4-fluorobenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H20FNO6
5-(3,4-Dimethoxyphenyl)-4-(4-fluorobenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C24H20FNO6
5-(4-Butoxyphenyl)-4-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H26FNO5
5-(4-Butoxyphenyl)-4-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C27H26FNO5
5-(4-Butoxy-3-methoxyphenyl)-4-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H28FNO6
5-(4-Butoxy-3-methoxyphenyl)-4-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C28H28FNO6
5-(2,4-Dichlorophenyl)-1-(furan-2-ylmethyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]pyrrolidine-2,3-dione chemical structure, C23H17Cl2NO5, CAS 5700-73-2
5-(2,4-Dichlorophenyl)-1-(furan-2-ylmethyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]pyrrolidine-2,3-dione
CAS 5700-73-2C23H17Cl2NO5
5-(4-Ethylphenyl)-4-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H22FNO4
5-(4-Ethylphenyl)-4-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C25H22FNO4
5-(3-Chlorophenyl)-4-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H17ClFNO4
5-(3-Chlorophenyl)-4-(3-fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-2,5-dihydro-1H-pyrrol-2-one
C23H17ClFNO4
5-(3,4-Dichlorophenyl)-4-(3-fluoro-4-methylbenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-1H-pyrrol-2(5H)-one chemical structure, C23H16Cl2FNO4, CAS 618074-02-5
5-(3,4-Dichlorophenyl)-4-(3-fluoro-4-methylbenzoyl)-1-(furan-2-ylmethyl)-3-hydroxy-1H-pyrrol-2(5H)-one
CAS 618074-02-5C23H16Cl2FNO4
5-(4-Ethylphenyl)-1-[(furan-2-yl)methyl]-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H25NO5
5-(4-Ethylphenyl)-1-[(furan-2-yl)methyl]-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C27H25NO5