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Murcko scaffold

Ring system with 4 rings and 26 atoms

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
12
With full pages
2
Scaffold SMILES

O=C1C(=O)N(Cc2ccco2)C(c2cccnc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)N(Cc2ccco2)C(c2cccnc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

1-[(Furan-2-yl)methyl]-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H18N2O5, CAS 609314-49-0
1-[(Furan-2-yl)methyl]-3-hydroxy-4-(3-methoxybenzoyl)-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 609314-49-0C22H18N2O5
4-[(3-Ethoxyphenyl)-hydroxymethylidene]-1-(furan-2-ylmethyl)-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C23H20N2O5
4-[(3-Ethoxyphenyl)-hydroxymethylidene]-1-(furan-2-ylmethyl)-5-pyridin-3-ylpyrrolidine-2,3-dione
C23H20N2O5
4-[(2,5-Dimethylphenyl)-hydroxymethylidene]-1-(furan-2-ylmethyl)-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C23H20N2O4
4-[(2,5-Dimethylphenyl)-hydroxymethylidene]-1-(furan-2-ylmethyl)-5-pyridin-3-ylpyrrolidine-2,3-dione
C23H20N2O4
4-(3-Fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H17FN2O4
4-(3-Fluoro-4-methylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C22H17FN2O4
1-[(Furan-2-yl)methyl]-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H20N2O5
1-[(Furan-2-yl)methyl]-3-hydroxy-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
C24H20N2O5
(4E)-1-(Furan-2-ylmethyl)-4-[hydroxy-(3-methoxyphenyl)methylidene]-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C22H18N2O5
(4E)-1-(Furan-2-ylmethyl)-4-[hydroxy-(3-methoxyphenyl)methylidene]-5-pyridin-3-ylpyrrolidine-2,3-dione
C22H18N2O5
4-(3-Ethoxybenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H20N2O5, CAS 609314-92-3
4-(3-Ethoxybenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 609314-92-3C23H20N2O5
4-(2,5-Dimethylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C23H20N2O4, CAS 609331-01-3
4-(2,5-Dimethylbenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 609331-01-3C23H20N2O4
(4E)-4-[(3-Fluoro-4-methylphenyl)-hydroxymethylidene]-1-(furan-2-ylmethyl)-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C22H17FN2O4, CAS 865593-16-4
(4E)-4-[(3-Fluoro-4-methylphenyl)-hydroxymethylidene]-1-(furan-2-ylmethyl)-5-pyridin-3-ylpyrrolidine-2,3-dione
CAS 865593-16-4C22H17FN2O4
(4E)-1-(Furan-2-ylmethyl)-4-[hydroxy-(4-prop-2-enoxyphenyl)methylidene]-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C24H20N2O5, CAS 867136-92-3
(4E)-1-(Furan-2-ylmethyl)-4-[hydroxy-(4-prop-2-enoxyphenyl)methylidene]-5-pyridin-3-ylpyrrolidine-2,3-dione
CAS 867136-92-3C24H20N2O5
4-[(3-Fluoro-4-methoxyphenyl)-hydroxymethylidene]-1-(furan-2-ylmethyl)-5-pyridin-3-ylpyrrolidine-2,3-dione chemical structure, C22H17FN2O5
4-[(3-Fluoro-4-methoxyphenyl)-hydroxymethylidene]-1-(furan-2-ylmethyl)-5-pyridin-3-ylpyrrolidine-2,3-dione
C22H17FN2O5
4-(3-Fluoro-4-methoxybenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H17FN2O5, CAS 889780-72-7
4-(3-Fluoro-4-methoxybenzoyl)-1-[(furan-2-yl)methyl]-3-hydroxy-5-(pyridin-3-yl)-2,5-dihydro-1H-pyrrol-2-one
CAS 889780-72-7C22H17FN2O5