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Murcko scaffold

Ring system with 4 rings and 26 atoms

24 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
24
With full pages
11
Scaffold SMILES

O=C(C1=CC(=O)N(Cc2cccnc2)C1c1ccccc1)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C1=CC(=O)N(Cc2cccnc2)C1c1ccccc1)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

5-(4-Fluorophenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H15FN2O3S, CAS 378761-12-7
5-(4-Fluorophenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 378761-12-7C21H15FN2O3S
5-(3-Bromophenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H15BrN2O3S, CAS 380866-42-2
5-(3-Bromophenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 380866-42-2C21H15BrN2O3S
3-Hydroxy-5-(4-methylphenyl)-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H18N2O3S, CAS 380581-83-9
3-Hydroxy-5-(4-methylphenyl)-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 380581-83-9C22H18N2O3S
3-Hydroxy-5-(3-nitrophenyl)-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C21H15N3O5S, CAS 380592-40-5
3-Hydroxy-5-(3-nitrophenyl)-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 380592-40-5C21H15N3O5S
(4E)-5-(4-Hydroxy-3-methoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C22H18N2O5S, CAS 370573-98-1
(4E)-5-(4-Hydroxy-3-methoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 370573-98-1C22H18N2O5S
(4E)-5-(4-Bromophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C21H15BrN2O3S, CAS 370870-96-5
(4E)-5-(4-Bromophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 370870-96-5C21H15BrN2O3S
5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H20N2O5S, CAS 439947-66-7
5-(3,4-Dimethoxyphenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 439947-66-7C23H20N2O5S
(4E)-5-[4-(Dimethylamino)phenyl]-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C23H21N3O3S, CAS 371135-29-4
(4E)-5-[4-(Dimethylamino)phenyl]-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 371135-29-4C23H21N3O3S
2-(3,4-Dichlorophenyl)-4-hydroxy-1-(pyridin-3-ylmethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C21H14Cl2N2O3S, CAS 371220-47-2
2-(3,4-Dichlorophenyl)-4-hydroxy-1-(pyridin-3-ylmethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 371220-47-2C21H14Cl2N2O3S
3-Hydroxy-5-(4-isopropylphenyl)-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C24H22N2O3S, CAS 370576-24-2
3-Hydroxy-5-(4-isopropylphenyl)-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 370576-24-2C24H22N2O3S
(4E)-5-(2-Fluorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C21H15FN2O3S, CAS 371927-84-3
(4E)-5-(2-Fluorophenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 371927-84-3C21H15FN2O3S
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C23H20N2O4S, CAS 371140-94-2
(4E)-5-(4-Ethoxyphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 371140-94-2C23H20N2O4S
(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione chemical structure, C24H22N2O6S, CAS 371232-17-6
(4E)-4-[Hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)-5-(3,4,5-trimethoxyphenyl)pyrrolidine-2,3-dione
CAS 371232-17-6C24H22N2O6S
5-(2,5-Dimethoxyphenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C23H20N2O5S, CAS 636991-51-0
5-(2,5-Dimethoxyphenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 636991-51-0C23H20N2O5S
3-Hydroxy-5-(4-propoxyphenyl)-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C24H22N2O4S, CAS 615271-38-0
3-Hydroxy-5-(4-propoxyphenyl)-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 615271-38-0C24H22N2O4S
3-Hydroxy-5-phenyl-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H16N2O3S, CAS 380154-79-0
3-Hydroxy-5-phenyl-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 380154-79-0C21H16N2O3S
2-(4-Ethoxy-3-methoxyphenyl)-4-hydroxy-1-(pyridin-3-ylmethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C24H22N2O5S, CAS 439947-67-8
2-(4-Ethoxy-3-methoxyphenyl)-4-hydroxy-1-(pyridin-3-ylmethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 439947-67-8C24H22N2O5S
3-Hydroxy-5-[4-(prop-2-en-1-yloxy)phenyl]-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C24H20N2O4S, CAS 442149-94-2
3-Hydroxy-5-[4-(prop-2-en-1-yloxy)phenyl]-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 442149-94-2C24H20N2O4S
4-Hydroxy-2-(3-prop-2-enoxyphenyl)-1-(pyridin-3-ylmethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one chemical structure, C24H20N2O4S, CAS 620152-01-4
4-Hydroxy-2-(3-prop-2-enoxyphenyl)-1-(pyridin-3-ylmethyl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
CAS 620152-01-4C24H20N2O4S
5-(3-Ethoxyphenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H20N2O4S, CAS 619271-50-0
5-(3-Ethoxyphenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 619271-50-0C23H20N2O4S
5-(3,4-Diethoxyphenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H24N2O5S, CAS 619273-90-4
5-(3,4-Diethoxyphenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-4-(thiophen-2-ylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 619273-90-4C25H24N2O5S
3-Hydroxy-5-(3-propoxyphenyl)-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one chemical structure, C24H22N2O4S, CAS 620151-30-6
3-Hydroxy-5-(3-propoxyphenyl)-1-(pyridin-3-ylmethyl)-4-(thiophene-2-carbonyl)-1H-pyrrol-2(5H)-one
CAS 620151-30-6C24H22N2O4S
5-(3-Butoxyphenyl)-3-hydroxy-1-(3-pyridinylmethyl)-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C25H24N2O4S, CAS 620152-77-4
5-(3-Butoxyphenyl)-3-hydroxy-1-(3-pyridinylmethyl)-4-(2-thienylcarbonyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 620152-77-4C25H24N2O4S
(4E)-5-(4-tert-Butylphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione chemical structure, C25H24N2O3S, CAS 371140-31-7
(4E)-5-(4-tert-Butylphenyl)-4-[hydroxy(thiophen-2-yl)methylidene]-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione
CAS 371140-31-7C25H24N2O3S