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Murcko scaffold

Ring system with 4 rings and 26 atoms

61 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
26
Chemicals
61
With full pages
14
Scaffold SMILES

O=C1C(=O)N(CC2CCCO2)C(c2ccccc2)C1=Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(=O)N(CC2CCCO2)C(c2ccccc2)C1=Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 61 chemicals

5-(2,5-Dimethoxyphenyl)-4-[(4-fluorophenyl)-hydroxymethylidene]-1-(oxolan-2-ylmethyl)pyrrolidine-2,3-dione chemical structure, C24H24FNO6, CAS 5173-37-5
5-(2,5-Dimethoxyphenyl)-4-[(4-fluorophenyl)-hydroxymethylidene]-1-(oxolan-2-ylmethyl)pyrrolidine-2,3-dione
CAS 5173-37-5C24H24FNO6
5-(4-Ethoxy-3-methoxyphenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H26FNO6
5-(4-Ethoxy-3-methoxyphenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C25H26FNO6
5-(4-Chlorophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H24ClNO5
5-(4-Chlorophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C25H24ClNO5
3-Hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C28H31NO5
3-Hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-5-[4-(propan-2-yl)phenyl]-2,5-dihydro-1H-pyrrol-2-one
C28H31NO5
3-Hydroxy-1-[(oxolan-2-yl)methyl]-5-phenyl-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H25NO5
3-Hydroxy-1-[(oxolan-2-yl)methyl]-5-phenyl-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C25H25NO5
5-(4-Chlorophenyl)-4-(4-ethoxybenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C24H24ClNO5
5-(4-Chlorophenyl)-4-(4-ethoxybenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C24H24ClNO5
3-Hydroxy-5-(4-methylphenyl)-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H27NO5
3-Hydroxy-5-(4-methylphenyl)-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C26H27NO5
5-(4-tert-Butylphenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C29H33NO5
5-(4-tert-Butylphenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C29H33NO5
5-(2-Fluorophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H24FNO5
5-(2-Fluorophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C25H24FNO5
5-(4-Ethylphenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C27H29NO5
5-(4-Ethylphenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C27H29NO5
5-(4-Butoxyphenyl)-4-(4-chlorobenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H28ClNO5
5-(4-Butoxyphenyl)-4-(4-chlorobenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C26H28ClNO5
5-(3-Fluorophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H24FNO5
5-(3-Fluorophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C25H24FNO5
5-(4-Bromophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H24BrNO5
5-(4-Bromophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C25H24BrNO5
5-(4-Fluorophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C25H24FNO5
5-(4-Fluorophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-4-[4-(prop-2-en-1-yloxy)benzoyl]-2,5-dihydro-1H-pyrrol-2-one
C25H24FNO5
5-(4-Butoxyphenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H28FNO5
5-(4-Butoxyphenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C26H28FNO5
5-(3-Ethoxy-4-hydroxyphenyl)-4-(4-ethoxybenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C26H29NO7
5-(3-Ethoxy-4-hydroxyphenyl)-4-(4-ethoxybenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
C26H29NO7
(4E)-5-(3-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(tetrahydrofuran-2-ylmethyl)pyrrolidine-2,3-dione chemical structure, C22H20FNO4, CAS 309283-08-7
(4E)-5-(3-Fluorophenyl)-4-[hydroxy(phenyl)methylidene]-1-(tetrahydrofuran-2-ylmethyl)pyrrolidine-2,3-dione
CAS 309283-08-7C22H20FNO4
(4E)-5-(4-Bromophenyl)-4-[hydroxy(phenyl)methylidene]-1-(tetrahydrofuran-2-ylmethyl)pyrrolidine-2,3-dione chemical structure, C22H20BrNO4, CAS 309276-23-1
(4E)-5-(4-Bromophenyl)-4-[hydroxy(phenyl)methylidene]-1-(tetrahydrofuran-2-ylmethyl)pyrrolidine-2,3-dione
CAS 309276-23-1C22H20BrNO4
4-Benzoyl-5-(3,4-dichlorophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H19Cl2NO4, CAS 618079-51-9
4-Benzoyl-5-(3,4-dichlorophenyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 618079-51-9C22H19Cl2NO4
5-(3-Bromophenyl)-4-(4-chlorobenzoyl)-3-hydroxy-1-(tetrahydro-2-furanylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H19BrClNO4, CAS 618074-48-9
5-(3-Bromophenyl)-4-(4-chlorobenzoyl)-3-hydroxy-1-(tetrahydro-2-furanylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 618074-48-9C22H19BrClNO4
(4E)-5-(4-Bromophenyl)-4-[(4-ethoxyphenyl)-hydroxymethylidene]-1-(oxolan-2-ylmethyl)pyrrolidine-2,3-dione chemical structure, C24H24BrNO5, CAS 618374-74-6
(4E)-5-(4-Bromophenyl)-4-[(4-ethoxyphenyl)-hydroxymethylidene]-1-(oxolan-2-ylmethyl)pyrrolidine-2,3-dione
CAS 618374-74-6C24H24BrNO5
4-(4-Bromobenzoyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(tetrahydro-2-furanylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C22H20BrNO5, CAS 617697-37-7
4-(4-Bromobenzoyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(tetrahydro-2-furanylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 617697-37-7C22H20BrNO5
5-(4-Chlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-(tetrahydro-2-furanylmethyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C23H22ClNO5, CAS 496798-24-4
5-(4-Chlorophenyl)-3-hydroxy-4-(4-methoxybenzoyl)-1-(tetrahydro-2-furanylmethyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 496798-24-4C23H22ClNO5
5-(3-Bromophenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C22H19BrFNO4, CAS 618374-52-0
5-(3-Bromophenyl)-4-(4-fluorobenzoyl)-3-hydroxy-1-[(oxolan-2-yl)methyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 618374-52-0C22H19BrFNO4