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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,825 to 1,872 of 6,403 chemicals

4-(4-Methylpiperazin-1-yl)benzoic acid hydrochloride chemical structure, C12H17ClN2O2, CAS 289044-60-6
4-(4-Methylpiperazin-1-yl)benzoic acid hydrochloride
CAS 289044-60-6C12H17ClN2O2
N-(2-((4-(3-Chlorophenyl)piperazin-1-yl)sulfonyl)ethyl)propionamide chemical structure, C15H22ClN3O3S, CAS 897612-69-0
N-(2-((4-(3-Chlorophenyl)piperazin-1-yl)sulfonyl)ethyl)propionamide
CAS 897612-69-0C15H22ClN3O3S
N-(2-((4-(3-Chlorophenyl)piperazin-1-yl)sulfonyl)ethyl)-3-methylbutanamide chemical structure, C17H26ClN3O3S, CAS 897612-71-4
N-(2-((4-(3-Chlorophenyl)piperazin-1-yl)sulfonyl)ethyl)-3-methylbutanamide
CAS 897612-71-4C17H26ClN3O3S
N-(2-((4-(3-Chlorophenyl)piperazin-1-yl)sulfonyl)ethyl)-2-ethylbutanamide chemical structure, C18H28ClN3O3S, CAS 897612-73-6
N-(2-((4-(3-Chlorophenyl)piperazin-1-yl)sulfonyl)ethyl)-2-ethylbutanamide
CAS 897612-73-6C18H28ClN3O3S
N-(2-{[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl}ethyl)-2-propylpentanamide chemical structure, C20H32ClN3O3S, CAS 897612-75-8
N-(2-{[4-(3-Chlorophenyl)piperazin-1-yl]sulfonyl}ethyl)-2-propylpentanamide
CAS 897612-75-8C20H32ClN3O3S
N-(2-((4-(2-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)butyramide chemical structure, C16H24FN3O3S, CAS 897613-31-9
N-(2-((4-(2-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)butyramide
CAS 897613-31-9C16H24FN3O3S
N-(2-((4-(2-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)pentanamide chemical structure, C17H26FN3O3S, CAS 897613-33-1
N-(2-((4-(2-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)pentanamide
CAS 897613-33-1C17H26FN3O3S
N-(2-{[4-(2-Fluorophenyl)piperazin-1-yl]sulfonyl}ethyl)-3-methylbutanamide chemical structure, C17H26FN3O3S, CAS 897613-35-3
N-(2-{[4-(2-Fluorophenyl)piperazin-1-yl]sulfonyl}ethyl)-3-methylbutanamide
CAS 897613-35-3C17H26FN3O3S
2-Ethyl-N-(2-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}ethyl)butanamide chemical structure, C18H28FN3O3S, CAS 897613-36-4
2-Ethyl-N-(2-{[4-(2-fluorophenyl)piperazin-1-yl]sulfonyl}ethyl)butanamide
CAS 897613-36-4C18H28FN3O3S
Ethyl (2-((4-(2-fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)carbamate chemical structure, C15H22FN3O4S, CAS 897618-37-0
Ethyl (2-((4-(2-fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)carbamate
CAS 897618-37-0C15H22FN3O4S
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)propionamide chemical structure, C15H22FN3O3S, CAS 897618-38-1
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)propionamide
CAS 897618-38-1C15H22FN3O3S
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)butyramide chemical structure, C16H24FN3O3S, CAS 897618-39-2
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)butyramide
CAS 897618-39-2C16H24FN3O3S
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)isobutyramide chemical structure, C16H24FN3O3S, CAS 897618-40-5
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)isobutyramide
CAS 897618-40-5C16H24FN3O3S
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)pentanamide chemical structure, C17H26FN3O3S, CAS 897618-41-6
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)pentanamide
CAS 897618-41-6C17H26FN3O3S
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)pivalamide chemical structure, C17H26FN3O3S, CAS 897618-42-7
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)pivalamide
CAS 897618-42-7C17H26FN3O3S
N-(2-{[4-(4-Fluorophenyl)piperazin-1-yl]sulfonyl}ethyl)-3-methylbutanamide chemical structure, C17H26FN3O3S, CAS 897618-43-8
N-(2-{[4-(4-Fluorophenyl)piperazin-1-yl]sulfonyl}ethyl)-3-methylbutanamide
CAS 897618-43-8C17H26FN3O3S
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)-3,3-dimethylbutanamide chemical structure, C18H28FN3O3S, CAS 897618-44-9
N-(2-((4-(4-Fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)-3,3-dimethylbutanamide
CAS 897618-44-9C18H28FN3O3S
2-Ethyl-N-(2-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}ethyl)butanamide chemical structure, C18H28FN3O3S, CAS 897618-45-0
2-Ethyl-N-(2-{[4-(4-fluorophenyl)piperazin-1-yl]sulfonyl}ethyl)butanamide
CAS 897618-45-0C18H28FN3O3S
N-(2-{[4-(4-Fluorophenyl)piperazin-1-yl]sulfonyl}ethyl)-2-propylpentanamide chemical structure, C20H32FN3O3S, CAS 897618-46-1
N-(2-{[4-(4-Fluorophenyl)piperazin-1-yl]sulfonyl}ethyl)-2-propylpentanamide
CAS 897618-46-1C20H32FN3O3S
Ethyl (2-((4-(4-fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)carbamate chemical structure, C15H22FN3O4S, CAS 897619-02-2
Ethyl (2-((4-(4-fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)carbamate
CAS 897619-02-2C15H22FN3O4S
N-(2-((4-(4-Methoxyphenyl)piperazin-1-yl)sulfonyl)ethyl)propionamide chemical structure, C16H25N3O4S, CAS 897619-03-3
N-(2-((4-(4-Methoxyphenyl)piperazin-1-yl)sulfonyl)ethyl)propionamide
CAS 897619-03-3C16H25N3O4S
N-(2-((4-(4-Methoxyphenyl)piperazin-1-yl)sulfonyl)ethyl)butyramide chemical structure, C17H27N3O4S, CAS 897619-04-4
N-(2-((4-(4-Methoxyphenyl)piperazin-1-yl)sulfonyl)ethyl)butyramide
CAS 897619-04-4C17H27N3O4S
N-(2-((4-(4-Methoxyphenyl)piperazin-1-yl)sulfonyl)ethyl)isobutyramide chemical structure, C17H27N3O4S, CAS 897619-05-5
N-(2-((4-(4-Methoxyphenyl)piperazin-1-yl)sulfonyl)ethyl)isobutyramide
CAS 897619-05-5C17H27N3O4S
N-(2-((4-(4-Methoxyphenyl)piperazin-1-yl)sulfonyl)ethyl)pentanamide chemical structure, C18H29N3O4S, CAS 897619-06-6
N-(2-((4-(4-Methoxyphenyl)piperazin-1-yl)sulfonyl)ethyl)pentanamide
CAS 897619-06-6C18H29N3O4S