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Murcko scaffold

1-Phenylpiperazine scaffold

6,403 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
6,403
With full pages
595
Scaffold SMILES

c1ccc(N2CCNCC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenylpiperazine page
Murcko scaffold c1ccc(N2CCNCC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1,777 to 1,824 of 6,403 chemicals

tert-Butyl 4-(4-amino-2,6-dichlorophenyl)piperazine-1-carboxylate chemical structure, C15H21Cl2N3O2, CAS 351325-24-1
tert-Butyl 4-(4-amino-2,6-dichlorophenyl)piperazine-1-carboxylate
CAS 351325-24-1C15H21Cl2N3O2
tert-Butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate chemical structure, C16H22F3N3O2, CAS 193902-87-3
tert-Butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate
CAS 193902-87-3C16H22F3N3O2
1-[4-(2-Methoxyphenyl)piperazin-1-yl]butane-1,3-dione chemical structure, C15H20N2O3, CAS 667919-95-1
1-[4-(2-Methoxyphenyl)piperazin-1-yl]butane-1,3-dione
CAS 667919-95-1C15H20N2O3
4-Chloro-3-(4-methylpiperazin-1-yl)aniline chemical structure, C11H16ClN3, CAS 148547-10-8
4-Chloro-3-(4-methylpiperazin-1-yl)aniline
CAS 148547-10-8C11H16ClN3
Ethyl 2-(4-(4-acetylpiperazin-1-yl)phenoxy)acetate chemical structure, C16H22N2O4, CAS 1361198-34-6
Ethyl 2-(4-(4-acetylpiperazin-1-yl)phenoxy)acetate
CAS 1361198-34-6C16H22N2O4
4-(Piperazin-1-yl)-3-trifluoromethyl-benzoic acid chemical structure, C12H13F3N2O2, CAS 773849-16-4
4-(Piperazin-1-yl)-3-trifluoromethyl-benzoic acid
CAS 773849-16-4C12H13F3N2O2
4-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)butan-1-ol chemical structure, C15H21F3N2O, CAS 223461-49-2
4-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)butan-1-ol
CAS 223461-49-2C15H21F3N2O
4-(4-(4-Hydroxybutyl)piperazin-1-yl)benzonitrile chemical structure, C15H21N3O, CAS 223461-46-9
4-(4-(4-Hydroxybutyl)piperazin-1-yl)benzonitrile
CAS 223461-46-9C15H21N3O
{3-[4-(2,5-Dimethylphenyl)piperazin-1-yl]propyl}amine chemical structure, C15H25N3, CAS 198287-09-1
{3-[4-(2,5-Dimethylphenyl)piperazin-1-yl]propyl}amine
CAS 198287-09-1C15H25N3
tert-Butyl 4-(2-cyanophenyl)piperazine-1-carboxylate chemical structure, C16H21N3O2, CAS 179250-25-0
tert-Butyl 4-(2-cyanophenyl)piperazine-1-carboxylate
CAS 179250-25-0C16H21N3O2
1-[4-(2-Methoxyphenyl)-1-piperazinyl]-2-propen-1-one chemical structure, C14H18N2O2, CAS 21057-24-9
1-[4-(2-Methoxyphenyl)-1-piperazinyl]-2-propen-1-one
CAS 21057-24-9C14H18N2O2
3-Fluoro-4-(4-methylpiperazin-1-yl)benzoic acid chemical structure, C12H15FN2O2, CAS 250683-76-2
3-Fluoro-4-(4-methylpiperazin-1-yl)benzoic acid
CAS 250683-76-2C12H15FN2O2
1-(5-Fluoro-2-methoxyphenyl)piperazine chemical structure, C11H15FN2O, CAS 102392-07-4
1-(5-Fluoro-2-methoxyphenyl)piperazine
CAS 102392-07-4C11H15FN2O
1-(4-Fluoro-2-methylphenyl)piperazine dihydrochloride chemical structure, C11H17Cl2FN2, CAS 223513-14-2
1-(4-Fluoro-2-methylphenyl)piperazine dihydrochloride
CAS 223513-14-2C11H17Cl2FN2
1-(4-Fluoro-2-methylphenyl)piperazine chemical structure, C11H15FN2, CAS 307952-16-5
1-(4-Fluoro-2-methylphenyl)piperazine
CAS 307952-16-5C11H15FN2
1-{4-Fluoro-2-[(propan-2-yl)oxy]phenyl}piperazine chemical structure, C13H19FN2O, CAS 148583-60-2
1-{4-Fluoro-2-[(propan-2-yl)oxy]phenyl}piperazine
CAS 148583-60-2C13H19FN2O
1-(2,4,6-Trifluorophenyl)piperazine chemical structure, C10H11F3N2, CAS 759443-28-2
1-(2,4,6-Trifluorophenyl)piperazine
CAS 759443-28-2C10H11F3N2
2-(4-Acetyl-piperazin-1-yl)-5-fluoroaniline chemical structure, C12H16FN3O, CAS 223513-02-8
2-(4-Acetyl-piperazin-1-yl)-5-fluoroaniline
CAS 223513-02-8C12H16FN3O
1-(2-Chloro-4-fluorophenyl)piperazine chemical structure, C10H12ClFN2, CAS 736122-94-4
1-(2-Chloro-4-fluorophenyl)piperazine
CAS 736122-94-4C10H12ClFN2
Methyl 3-fluoro-4-(piperazin-1-yl)benzoate chemical structure, C12H15FN2O2, CAS 234082-10-1
Methyl 3-fluoro-4-(piperazin-1-yl)benzoate
CAS 234082-10-1C12H15FN2O2
Ethyl 4-(3,5-dimethylpiperazin-1-yl)benzoate chemical structure, C15H22N2O2, CAS 1035271-01-2
Ethyl 4-(3,5-dimethylpiperazin-1-yl)benzoate
CAS 1035271-01-2C15H22N2O2
Methyl 3-Chloro-4-piperazinobenzoate chemical structure, C12H15ClN2O2, CAS 234082-16-7
Methyl 3-Chloro-4-piperazinobenzoate
CAS 234082-16-7C12H15ClN2O2
Ethyl 4-(3-methylpiperazin-1-yl)benzoate chemical structure, C14H20N2O2, CAS 234081-81-3
Ethyl 4-(3-methylpiperazin-1-yl)benzoate
CAS 234081-81-3C14H20N2O2
Methyl 2-fluoro-4-(piperazin-1-yl)benzoate chemical structure, C12H15FN2O2, CAS 234082-13-4
Methyl 2-fluoro-4-(piperazin-1-yl)benzoate
CAS 234082-13-4C12H15FN2O2