Murcko scaffold
Ring system with 2 rings and 13 atoms
126 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 13
- Chemicals
- 126
- With full pages
- 4
Scaffold SMILES
O=c1ccn(C2CCCS2)c(=O)[nH]1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=c1ccn(C2CCCS2)c(=O)[nH]1](/scaffold/ZACDILNLIBRNGL-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 126 chemicals
4'-Thiothymidine
CAS 134111-33-4C10H14N2O4S
1-(2'-Tetrahydrothienyl) 5-fluorouracil
CAS 68321-44-8C8H9FN2O2S
2'-Deoxy-4'-methyl-4'-thiothymidine
CAS 152594-60-0C11H16N2O4S
Uridine, 5-fluoro-4'-thio-
CAS 56527-42-5C9H11FN2O5S
4'-Thio-3'-deoxythymidine
CAS 137819-79-5C10H14N2O3S
2'-Deoxy-5-ethyl-4'-thiouridine
CAS 134699-96-0C11H16N2O4S
![1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-nitro-pyrimidine-2,4-dione chemical structure, C9H11N3O6S, CAS 135123-28-3](/s/IAGKOEAPVAYACR-RRKCRQDMSA-N.svg)
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-nitro-pyrimidine-2,4-dione
CAS 135123-28-3C9H11N3O6S
![1-[(2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-ethyl-pyrimidine-2,4-dione chemical structure, C11H16N2O5S, CAS 187590-59-6](/s/GLNMEPIIMNFBGH-ODXREFDESA-N.svg)
1-[(2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-ethyl-pyrimidine-2,4-dione
CAS 187590-59-6C11H16N2O5S
![1-[(2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-methyl-pyrimidine-2,4-dione chemical structure, C10H14N2O5S, CAS 187590-62-1](/s/CKHFVQVATAWGSH-JAKMQLQISA-N.svg)
1-[(2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-methyl-pyrimidine-2,4-dione
CAS 187590-62-1C10H14N2O5S
![1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-methyl-pyrimidine-2,4-dione chemical structure, C10H14N2O5S, CAS 26527-36-6](/s/CKHFVQVATAWGSH-JAGXHNFQSA-N.svg)
1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-methyl-pyrimidine-2,4-dione
CAS 26527-36-6C10H14N2O5S
![1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-iodo-pyrimidine-2,4-dione chemical structure, C9H11IN2O5S, CAS 187590-67-6](/s/RCNVWVGXQUQABH-MNCSTQPFSA-N.svg)
1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-iodo-pyrimidine-2,4-dione
CAS 187590-67-6C9H11IN2O5S
3'-Azido-3'-deoxy-4'-thiothymidine
CAS 134939-00-7C10H13N5O3S
![1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-propyl-pyrimidine-2,4-dione chemical structure, C12H18N2O4S, CAS 134700-09-7](/s/FLKWXTHVVIQNHN-IVZWLZJFSA-N.svg)
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-propyl-pyrimidine-2,4-dione
CAS 134700-09-7C12H18N2O4S
![1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-isopropyl-pyrimidine-2,4-dione chemical structure, C12H18N2O4S, CAS 174357-89-2](/s/SPOAVKIVMOYLQL-IVZWLZJFSA-N.svg)
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-isopropyl-pyrimidine-2,4-dione
CAS 174357-89-2C12H18N2O4S
![1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-sec-butyl-pyrimidine-2,4-dione chemical structure, C13H20N2O4S, CAS 174357-92-7](/s/XHYDFBYSTTYMHM-LTYKLIDASA-N.svg)
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-sec-butyl-pyrimidine-2,4-dione
CAS 174357-92-7C13H20N2O4S
![5-tert-Butyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione chemical structure, C13H20N2O4S, CAS 174357-93-8](/s/LLAYHABBEHJNRR-IVZWLZJFSA-N.svg)
5-tert-Butyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione
CAS 174357-93-8C13H20N2O4S
![1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-vinyl-pyrimidine-2,4-dione chemical structure, C11H14N2O4S, CAS 174357-95-0](/s/XLHPUMFOCIGRBQ-DJLDLDEBSA-N.svg)
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-vinyl-pyrimidine-2,4-dione
CAS 174357-95-0C11H14N2O4S
![1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-isopropenyl-pyrimidine-2,4-dione chemical structure, C12H16N2O4S, CAS 174357-96-1](/s/SHFFLJGXXYSQCO-IVZWLZJFSA-N.svg)
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-isopropenyl-pyrimidine-2,4-dione
CAS 174357-96-1C12H16N2O4S
2'-Deoxy-5-ethynyl-4'-thiouridine
CAS 134700-06-4C11H12N2O4S
![5-(2-Fluoroethyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione chemical structure, C11H15FN2O4S, CAS 174358-06-6](/s/QDSHRNSPNCWNIV-DJLDLDEBSA-N.svg)
5-(2-Fluoroethyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione
CAS 174358-06-6C11H15FN2O4S
![5-(2-Chloroethyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione chemical structure, C11H15ClN2O4S, CAS 135123-27-2](/s/MIUSDJNJAXYSMS-DJLDLDEBSA-N.svg)
5-(2-Chloroethyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione
CAS 135123-27-2C11H15ClN2O4S
![5-(2,2-Difluorovinyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione chemical structure, C11H12F2N2O4S, CAS 174358-09-9](/s/JHANSEIWJFWGNA-LKEWCRSYSA-N.svg)
5-(2,2-Difluorovinyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione
CAS 174358-09-9C11H12F2N2O4S
![5-(2,2-Dichloro-1-fluoro-vinyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione chemical structure, C11H11Cl2FN2O4S, CAS 174358-11-3](/s/MHRRXVDFIDEAGA-RRKCRQDMSA-N.svg)
5-(2,2-Dichloro-1-fluoro-vinyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione
CAS 174358-11-3C11H11Cl2FN2O4S
2'-Deoxy-5-methoxy-4'-thiouridine
CAS 174358-15-7C10H14N2O5S
- 1 suppliers2'-Deoxy-5-fluoro-4'-thiouridine68660-47-9C9H11FN2O4S
- 5-Chloro-2'-deoxy-4'-thiouridine134700-02-0C9H11ClN2O4S
- 1 suppliers5-Bromo-2'-deoxy-4'-thiouridine134699-98-2C9H11BrN2O4S
- 1 suppliers2'-Deoxy-5-iodo-4'-thiouridine134699-95-9C9H11IN2O4S
- 5-Cyano-2'-deoxy-4'-thiouridine174358-16-8C10H11N3O4S
- 1-(5-Hydroxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione145887-08-7C9H12N2O3S
- 1-(3-Fluoro-5-hydroxymethyl-tetrahydro-thiophen-2-yl)-1H-pyrimidine-2,4-dione165399-47-3C9H11FN2O3S
- 1-[(2R,4S,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione166249-14-5C9H11FN2O3S
- 1-[(2S,3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione222192-00-9C9H12N2O5S
- 1 suppliers1-[(2S,3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-methyl-pyrimidine-2,4-dione208755-46-8C10H14N2O5S
- Albomycin1414-39-7C36H58FeN10O18S+3
- 1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-ethyl-pyrimidine-2,4-dione135123-32-9C11H16N2O5S
- 5-(2-Bromovinyl)-2'-deoxy-4'-thiouridine134699-93-7C11H13BrN2O4S
- 1 suppliers1-(4'-Thio-beta-ribofuranosyl)thymine6741-71-5C10H14N2O5S
- 1 suppliers5-[(E)-2-Bromovinyl]-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione135123-29-4C11H13BrN2O5S
- 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-[(E)-prop-1-enyl]pyrimidine-2,4-dione134779-54-7C12H16N2O4S
- 5-[(E)-2-Chlorovinyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]pyrimidine-2,4-dione174358-10-2C11H13ClN2O4S
- 1-[(2R,4R,5S)-4,5-Bis(hydroxymethyl)tetrahydrothiophen-2-yl]-5-methyl-pyrimidine-2,4-dione154819-75-7C11H16N2O4S
- 1-[(2R,4S,5S)-4-Azido-5-(hydroxymethyl)thiolan-2-yl]-5-chloropyrimidine-2,4-dione143764-22-1C9H10ClN5O3S
- 1-[(2R,4S,5S)-4-Azido-5-(hydroxymethyl)thiolan-2-yl]-5-fluoropyrimidine-2,4-dione143764-21-0C9H10FN5O3S
- 1-(2-Deoxy-4-thio-|A-L-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione153439-74-8C10H14N2O4S
- Ivudhnyltwoarv-biivosgpsa-153439-73-7C10H14N2O4S
- 1-(2-Deoxy-4-thio-|A-L-erythro-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione160452-67-5C9H12N2O4S
- 3'-Azido-5-bromo-2',3'-dideoxy-4'-thiouridine163357-03-7C9H10BrN5O3S
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