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Murcko scaffold

Ring system with 2 rings and 13 atoms

126 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
126
With full pages
4
Scaffold SMILES

O=c1ccn(C2CCCS2)c(=O)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ccn(C2CCCS2)c(=O)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 126 chemicals

1-(2-Deoxy-4-thio-|A-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione chemical structure, C10H14N2O4S, CAS 160452-68-6
1-(2-Deoxy-4-thio-|A-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
CAS 160452-68-6C10H14N2O4S
Lvrcvagowtvsgy-zxflcmhbsa- chemical structure, C10H14N2O4S, CAS 168332-06-7
Lvrcvagowtvsgy-zxflcmhbsa-
CAS 168332-06-7C10H14N2O4S
1-(2-Deoxy-4-thio-alpha-D-ribofuranosyl)uracil chemical structure, C9H12N2O4S, CAS 134111-34-5
1-(2-Deoxy-4-thio-alpha-D-ribofuranosyl)uracil
CAS 134111-34-5C9H12N2O4S
1-(2-Deoxy-4-thio-|A-L-threo-pentofuranosyl)-5-fluoro-2,4(1H,3H)-pyrimidinedione chemical structure, C9H11FN2O4S, CAS 338742-45-3
1-(2-Deoxy-4-thio-|A-L-threo-pentofuranosyl)-5-fluoro-2,4(1H,3H)-pyrimidinedione
CAS 338742-45-3C9H11FN2O4S
1-(2-Deoxy-4-thio-|A-D-erythro-pentofuranosyl)-5-fluoro-2,4(1H,3H)-pyrimidinedione chemical structure, C9H11FN2O4S, CAS 68660-46-8
1-(2-Deoxy-4-thio-|A-D-erythro-pentofuranosyl)-5-fluoro-2,4(1H,3H)-pyrimidinedione
CAS 68660-46-8C9H11FN2O4S
1-(2-Deoxy-4-thio-|A-D-erythro-pentofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione chemical structure, C11H16N2O4S, CAS 134699-97-1
1-(2-Deoxy-4-thio-|A-D-erythro-pentofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione
CAS 134699-97-1C11H16N2O4S
1-[(2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-iodo-pyrimidine-2,4-dione chemical structure, C9H11IN2O5S, CAS 187590-65-4
1-[(2S,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-iodo-pyrimidine-2,4-dione
CAS 187590-65-4C9H11IN2O5S
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-(tetrahydro-2-thienyl)- chemical structure, C9H12N2O2S, CAS 145220-09-3
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-(tetrahydro-2-thienyl)-
CAS 145220-09-3C9H12N2O2S
1-[(2S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-methylpyrimidine-2,4-dione chemical structure, C10H14N2O4S, CAS 134111-35-6
1-[(2S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)thiolan-2-yl]-5-methylpyrimidine-2,4-dione
CAS 134111-35-6C10H14N2O4S
4'-Thiouridine chemical structure, C9H12N2O5S, CAS 6741-73-7
4'-Thiouridine
CAS 6741-73-7C9H12N2O5S
4'-Thiouridine 5'-triphosphate chemical structure, C9H15N2O14P3S, CAS 667882-44-2
4'-Thiouridine 5'-triphosphate
CAS 667882-44-2C9H15N2O14P3S
1-[(2R,3S,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-methyl-pyrimidine-2,4-dione chemical structure, C10H13FN2O4S, CAS 135123-34-1
1-[(2R,3S,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl]-5-methyl-pyrimidine-2,4-dione
CAS 135123-34-1C10H13FN2O4S
3'-Azido-2',3'-dideoxy-4'-thiouridine chemical structure, C9H11N5O3S, CAS 143764-23-2
3'-Azido-2',3'-dideoxy-4'-thiouridine
CAS 143764-23-2C9H11N5O3S
1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidine-2,4-dione chemical structure, C9H12N2O5S, CAS 26527-35-5
1-[(2R,3S,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidine-2,4-dione
CAS 26527-35-5C9H12N2O5S
5-[(E)-2-Bromoethenyl]-1-[(2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidine-2,4-dione chemical structure, C11H13BrN2O4S, CAS 134699-94-8
5-[(E)-2-Bromoethenyl]-1-[(2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidine-2,4-dione
CAS 134699-94-8C11H13BrN2O4S
2'-Deoxy-2'-fluoro-5-methyl-4'-thio-a-D-arabinouridine chemical structure, C10H13FN2O4S, CAS 294868-24-9
2'-Deoxy-2'-fluoro-5-methyl-4'-thio-a-D-arabinouridine
CAS 294868-24-9C10H13FN2O4S
5-[(1E)-2-Bromoethenyl]-2',3'-dideoxy-3'-(hydroxymethyl)-4'-thiouridine chemical structure, C12H15BrN2O4S, CAS 224581-26-4
5-[(1E)-2-Bromoethenyl]-2',3'-dideoxy-3'-(hydroxymethyl)-4'-thiouridine
CAS 224581-26-4C12H15BrN2O4S
5-Methyl-1-(4-thio-|A-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione chemical structure, C10H14N2O5S, CAS 6741-72-6
5-Methyl-1-(4-thio-|A-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione
CAS 6741-72-6C10H14N2O5S
1-(4-Thio-|A-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione chemical structure, C9H12N2O5S, CAS 6742-14-9
1-(4-Thio-|A-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione
CAS 6742-14-9C9H12N2O5S
2'-Deoxy-4'-thiouridine chemical structure, C9H12N2O4S, CAS 134111-32-3
2'-Deoxy-4'-thiouridine
CAS 134111-32-3C9H12N2O4S
2'-Deoxy-5-(1-propynyl)-4'-thiouridine chemical structure, C12H14N2O4S, CAS 134700-00-8
2'-Deoxy-5-(1-propynyl)-4'-thiouridine
CAS 134700-00-8C12H14N2O4S
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-(4-thio-L-xylofuranosyl)- chemical structure, C10H14N2O5S, CAS 358359-82-7
2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-(4-thio-L-xylofuranosyl)-
CAS 358359-82-7C10H14N2O5S
1-(4-Thio-L-xylofuranosyl)-2,4(1H,3H)-pyrimidinedione chemical structure, C9H12N2O5S, CAS 358359-79-2
1-(4-Thio-L-xylofuranosyl)-2,4(1H,3H)-pyrimidinedione
CAS 358359-79-2C9H12N2O5S
5-Fluoro-4'-thiouridine chemical structure, C9H11FN2O5S
5-Fluoro-4'-thiouridine
C9H11FN2O5S