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Murcko scaffold

Ring system with 3 rings and 21 atoms

37 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
37
With full pages
5
Scaffold SMILES

O=C(Nc1ccccc1)Nc1ccnn1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)Nc1ccnn1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 37 of 37 chemicals

N-((3Z)-5-tert-Butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene)-N'-(4-chlorophenyl)urea chemical structure, C20H21ClN4O, CAS 443912-63-8
N-((3Z)-5-tert-Butyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-ylidene)-N'-(4-chlorophenyl)urea
CAS 443912-63-8C20H21ClN4O
3-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-phenylurea chemical structure, C17H16N4O, CAS 337975-77-6
3-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-phenylurea
CAS 337975-77-6C17H16N4O
3-(3-tert-Butyl-1-phenyl-1H-pyrazol-5-yl)-1-phenylurea chemical structure, C20H22N4O, CAS 443912-88-7
3-(3-tert-Butyl-1-phenyl-1H-pyrazol-5-yl)-1-phenylurea
CAS 443912-88-7C20H22N4O
N-[1-[4-(Chlorodifluoromethoxy)phenyl]-3-methyl-1H-pyrazol-5-yl]-N'-(4-methylphenyl)urea chemical structure, C19H17ClF2N4O2, CAS 497141-60-3
N-[1-[4-(Chlorodifluoromethoxy)phenyl]-3-methyl-1H-pyrazol-5-yl]-N'-(4-methylphenyl)urea
CAS 497141-60-3C19H17ClF2N4O2
1-(4-Chlorophenyl)-3-(5-methyl-2-phenylpyrazol-3-yl)urea chemical structure, C17H15ClN4O, CAS 700833-46-1
1-(4-Chlorophenyl)-3-(5-methyl-2-phenylpyrazol-3-yl)urea
CAS 700833-46-1C17H15ClN4O
1-(3-Tert-Butyl-1-Phenyl-1H-Pyrazol-5-Yl)-3-(2,3-Dichlorophenyl)urea chemical structure, C20H20Cl2N4O, CAS 227622-85-7
1-(3-Tert-Butyl-1-Phenyl-1H-Pyrazol-5-Yl)-3-(2,3-Dichlorophenyl)urea
CAS 227622-85-7C20H20Cl2N4O
1-[1-(3-Methoxyphenyl)-3-tert-butyl-1H-pyrazole-5-yl]-3-(2,3-dichlorophenyl)urea chemical structure, C21H22Cl2N4O2, CAS 127411-67-0
1-[1-(3-Methoxyphenyl)-3-tert-butyl-1H-pyrazole-5-yl]-3-(2,3-dichlorophenyl)urea
CAS 127411-67-0C21H22Cl2N4O2
1-[5-tert-Butyl-2-(4-methoxy-phenyl)-2H-pyrazol-3-yl]-3-(2,3-dichloro-phenyl)-urea chemical structure, C21H22Cl2N4O2, CAS 725686-46-4
1-[5-tert-Butyl-2-(4-methoxy-phenyl)-2H-pyrazol-3-yl]-3-(2,3-dichloro-phenyl)-urea
CAS 725686-46-4C21H22Cl2N4O2
3-[1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-1-(2,3-dichlorophenyl)urea chemical structure, C20H21Cl2N5O, CAS 227622-98-2
3-[1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-1-(2,3-dichlorophenyl)urea
CAS 227622-98-2C20H21Cl2N5O
1-Phenyl-3-[1-phenyl-3-(propan-2-yl)-1H-pyrazol-5-yl]urea chemical structure, C19H20N4O, CAS 443912-98-9
1-Phenyl-3-[1-phenyl-3-(propan-2-yl)-1H-pyrazol-5-yl]urea
CAS 443912-98-9C19H20N4O
1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)-3-phenylurea chemical structure, C20H23N5O, CAS 443912-94-5
1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)-3-phenylurea
CAS 443912-94-5C20H23N5O
1-(3-tert-Butyl-1-(3-(chloromethyl)phenyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea chemical structure, C21H22Cl2N4O, CAS 725685-99-4
1-(3-tert-Butyl-1-(3-(chloromethyl)phenyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea
CAS 725685-99-4C21H22Cl2N4O
1-(3-tert-Butyl-1-(3-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea chemical structure, C21H23ClN4O2, CAS 725685-98-3
1-(3-tert-Butyl-1-(3-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea
CAS 725685-98-3C21H23ClN4O2
Ethyl 3-{3-t-butyl-5-[3-(4-chlorophenyl)ureido]-1H-pyrazol-1-yl}benzoate chemical structure, C23H25ClN4O3, CAS 725685-95-0
Ethyl 3-{3-t-butyl-5-[3-(4-chlorophenyl)ureido]-1H-pyrazol-1-yl}benzoate
CAS 725685-95-0C23H25ClN4O3
Ethyl 3-[3-(1,1-dimethylethyl)-5-[[(phenylamino)carbonyl]amino]-1H-pyrazol-1-yl]benzoate chemical structure, C23H26N4O3, CAS 1044462-36-3
Ethyl 3-[3-(1,1-dimethylethyl)-5-[[(phenylamino)carbonyl]amino]-1H-pyrazol-1-yl]benzoate
CAS 1044462-36-3C23H26N4O3
Ethyl 3-{3-t-butyl-5-[3-(4-fluorophenyl)ureido)-1H-pyrazol-1-yl}benzoate chemical structure, C23H25FN4O3, CAS 897370-02-4
Ethyl 3-{3-t-butyl-5-[3-(4-fluorophenyl)ureido)-1H-pyrazol-1-yl}benzoate
CAS 897370-02-4C23H25FN4O3
1-(3-(tert-Butyl)-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea chemical structure, C20H21ClN4O2, CAS 725686-66-8
1-(3-(tert-Butyl)-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea
CAS 725686-66-8C20H21ClN4O2
1-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea chemical structure, C21H23ClN4O2, CAS 725686-65-7
1-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)-3-(4-chlorophenyl)urea
CAS 725686-65-7C21H23ClN4O2
2-[3-(3-tert-Butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1H-pyrazol-1-yl)phenyl]acetamide chemical structure, C22H23Cl2N5O2, CAS 897367-47-4
2-[3-(3-tert-Butyl-5-{[(2,3-dichlorophenyl)carbamoyl]imino}-2,5-dihydro-1H-pyrazol-1-yl)phenyl]acetamide
CAS 897367-47-4C22H23Cl2N5O2
ML 297 chemical structure, C17H14F2N4O, CAS 1443246-62-5
ML 297
CAS 1443246-62-5C17H14F2N4O
Ethyl 4-[5-[3-(4-chlorophenyl)ureido]-3-isopropyl-1H-pyrazol-1-yl]benzoate chemical structure, C22H23ClN4O3, CAS 897375-54-1
Ethyl 4-[5-[3-(4-chlorophenyl)ureido]-3-isopropyl-1H-pyrazol-1-yl]benzoate
CAS 897375-54-1C22H23ClN4O3
Ethyl 4-[5-[3-(4-chlorophenyl)ureido]-3-methyl-1H-pyrazol-1-yl]benzoate chemical structure, C20H19ClN4O3, CAS 903567-16-8
Ethyl 4-[5-[3-(4-chlorophenyl)ureido]-3-methyl-1H-pyrazol-1-yl]benzoate
CAS 903567-16-8C20H19ClN4O3
Ethyl 2-[4-[3-tert-butyl-5-[3-(4-chlorophenyl)ureido]-1H-pyrazol-1-yl]phenyl]acetate chemical structure, C24H27ClN4O3, CAS 897375-63-2
Ethyl 2-[4-[3-tert-butyl-5-[3-(4-chlorophenyl)ureido]-1H-pyrazol-1-yl]phenyl]acetate
CAS 897375-63-2C24H27ClN4O3
Ethyl 4-[5-[(4-chlorophenyl)carbamoylamino]-3-(trifluoromethyl)pyrazol-1-yl]benzoate chemical structure, C20H16ClF3N4O3, CAS 897375-56-3
Ethyl 4-[5-[(4-chlorophenyl)carbamoylamino]-3-(trifluoromethyl)pyrazol-1-yl]benzoate
CAS 897375-56-3C20H16ClF3N4O3