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Murcko scaffold

Ring system with 3 rings and 21 atoms

205 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
205
With full pages
10
Scaffold SMILES

O=C(NCc1nncn1-c1ccccc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCc1nncn1-c1ccccc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 205 chemicals

4-Fluoro-N-{[5-(methylsulfanyl)-4-phenyl-4H-1,2,4-triazol-3-yl]methyl}benzenecarboxamide chemical structure, C17H15FN4OS, CAS 338962-49-5
4-Fluoro-N-{[5-(methylsulfanyl)-4-phenyl-4H-1,2,4-triazol-3-yl]methyl}benzenecarboxamide
CAS 338962-49-5C17H15FN4OS
Ethyl 2-[(5-{[(4-fluorobenzoyl)amino]methyl}-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate chemical structure, C20H19FN4O3S, CAS 338962-50-8
Ethyl 2-[(5-{[(4-fluorobenzoyl)amino]methyl}-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate
CAS 338962-50-8C20H19FN4O3S
Methyl 2-[[5-[[(3,5-dimethoxybenzoyl)amino]methyl]-4-(2,5-dimethylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetate chemical structure, C23H26N4O5S, CAS 689747-00-0
Methyl 2-[[5-[[(3,5-dimethoxybenzoyl)amino]methyl]-4-(2,5-dimethylphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetate
CAS 689747-00-0C23H26N4O5S
Ethyl 2-((5-((3,5-dimethoxybenzamido)methyl)-4-(2,5-dimethylphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C24H28N4O5S, CAS 689747-06-6
Ethyl 2-((5-((3,5-dimethoxybenzamido)methyl)-4-(2,5-dimethylphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689747-06-6C24H28N4O5S
Methyl 2-((5-((3,5-dimethoxybenzamido)methyl)-4-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C21H21FN4O5S, CAS 689747-13-5
Methyl 2-((5-((3,5-dimethoxybenzamido)methyl)-4-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689747-13-5C21H21FN4O5S
Ethyl 2-((5-((3,5-dimethoxybenzamido)methyl)-4-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C22H23FN4O5S, CAS 689747-19-1
Ethyl 2-((5-((3,5-dimethoxybenzamido)methyl)-4-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689747-19-1C22H23FN4O5S
Ethyl 2-((5-((2-fluorobenzamido)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C20H19FN4O3S, CAS 689747-55-5
Ethyl 2-((5-((2-fluorobenzamido)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689747-55-5C20H19FN4O3S
Ethyl 2-((5-((2-fluorobenzamido)methyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C21H21FN4O4S, CAS 689747-59-9
Ethyl 2-((5-((2-fluorobenzamido)methyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689747-59-9C21H21FN4O4S
Methyl 2-((4-(4-ethoxyphenyl)-5-((2-fluorobenzamido)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C21H21FN4O4S, CAS 689747-64-6
Methyl 2-((4-(4-ethoxyphenyl)-5-((2-fluorobenzamido)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689747-64-6C21H21FN4O4S
Ethyl 2-((4-(4-ethoxyphenyl)-5-((2-fluorobenzamido)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C22H23FN4O4S, CAS 689747-69-1
Ethyl 2-((4-(4-ethoxyphenyl)-5-((2-fluorobenzamido)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689747-69-1C22H23FN4O4S
Methyl 2-[[5-[[(2-fluorobenzoyl)amino]methyl]-4-(4-fluorophenyl)-1,2,4-triazol-3-yl]sulfanyl]acetate chemical structure, C19H16F2N4O3S, CAS 689747-74-8
Methyl 2-[[5-[[(2-fluorobenzoyl)amino]methyl]-4-(4-fluorophenyl)-1,2,4-triazol-3-yl]sulfanyl]acetate
CAS 689747-74-8C19H16F2N4O3S
Ethyl 2-((5-((2-fluorobenzamido)methyl)-4-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C20H18F2N4O3S, CAS 689747-79-3
Ethyl 2-((5-((2-fluorobenzamido)methyl)-4-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689747-79-3C20H18F2N4O3S
Methyl 2-((5-((2-fluorobenzamido)methyl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C20H16F4N4O3S, CAS 689747-84-0
Methyl 2-((5-((2-fluorobenzamido)methyl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689747-84-0C20H16F4N4O3S
Ethyl 2-((5-((2-fluorobenzamido)methyl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C21H18F4N4O3S, CAS 689747-89-5
Ethyl 2-((5-((2-fluorobenzamido)methyl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689747-89-5C21H18F4N4O3S
Methyl 2-[[5-[[(3-fluorobenzoyl)amino]methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetate chemical structure, C19H17FN4O3S, CAS 689748-04-7
Methyl 2-[[5-[[(3-fluorobenzoyl)amino]methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetate
CAS 689748-04-7C19H17FN4O3S
Ethyl 2-[[5-[[(3-fluorobenzoyl)amino]methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetate chemical structure, C20H19FN4O3S, CAS 689748-08-1
Ethyl 2-[[5-[[(3-fluorobenzoyl)amino]methyl]-4-phenyl-1,2,4-triazol-3-yl]sulfanyl]acetate
CAS 689748-08-1C20H19FN4O3S
Methyl 2-[[4-(2,5-dimethylphenyl)-5-[[(3-fluorobenzoyl)amino]methyl]-1,2,4-triazol-3-yl]sulfanyl]acetate chemical structure, C21H21FN4O3S, CAS 689748-11-6
Methyl 2-[[4-(2,5-dimethylphenyl)-5-[[(3-fluorobenzoyl)amino]methyl]-1,2,4-triazol-3-yl]sulfanyl]acetate
CAS 689748-11-6C21H21FN4O3S
Ethyl 2-[[4-(2,5-dimethylphenyl)-5-[[(3-fluorobenzoyl)amino]methyl]-1,2,4-triazol-3-yl]sulfanyl]acetate chemical structure, C22H23FN4O3S, CAS 689748-15-0
Ethyl 2-[[4-(2,5-dimethylphenyl)-5-[[(3-fluorobenzoyl)amino]methyl]-1,2,4-triazol-3-yl]sulfanyl]acetate
CAS 689748-15-0C22H23FN4O3S
Methyl 2-((5-((3-fluorobenzamido)methyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C20H19FN4O4S, CAS 689748-20-7
Methyl 2-((5-((3-fluorobenzamido)methyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689748-20-7C20H19FN4O4S
Ethyl 2-((5-((3-fluorobenzamido)methyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C21H21FN4O4S, CAS 689748-25-2
Ethyl 2-((5-((3-fluorobenzamido)methyl)-4-(2-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689748-25-2C21H21FN4O4S
Ethyl 2-((5-((3-fluorobenzamido)methyl)-4-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C21H21FN4O4S, CAS 689748-30-9
Ethyl 2-((5-((3-fluorobenzamido)methyl)-4-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689748-30-9C21H21FN4O4S
Methyl 2-[[4-(4-ethoxyphenyl)-5-[[(3-fluorobenzoyl)amino]methyl]-1,2,4-triazol-3-yl]sulfanyl]acetate chemical structure, C21H21FN4O4S, CAS 689748-35-4
Methyl 2-[[4-(4-ethoxyphenyl)-5-[[(3-fluorobenzoyl)amino]methyl]-1,2,4-triazol-3-yl]sulfanyl]acetate
CAS 689748-35-4C21H21FN4O4S
Ethyl 2-((4-(4-ethoxyphenyl)-5-((3-fluorobenzamido)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate chemical structure, C22H23FN4O4S, CAS 689748-40-1
Ethyl 2-((4-(4-ethoxyphenyl)-5-((3-fluorobenzamido)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate
CAS 689748-40-1C22H23FN4O4S
Methyl 2-[[5-[[(2-methoxybenzoyl)amino]methyl]-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetate chemical structure, C21H22N4O5S, CAS 689749-42-6
Methyl 2-[[5-[[(2-methoxybenzoyl)amino]methyl]-4-(4-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanyl]acetate
CAS 689749-42-6C21H22N4O5S