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Murcko scaffold

Ring system with 3 rings and 22 atoms

90 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 90
With full pages: 3

Scaffold SMILES

O=C(NCc1n[nH]c(=S)n1-c1ccccc1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NCc1n[nH]c(=S)n1-c1ccccc1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 90 chemicals

3-Methyl-N-[(4-phenyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]benzamide chemical structure, C17H16N4OS, CAS 391886-57-0

3-Methyl-N-[(4-phenyl-5-sulfanyl-4H-1,2,4-triazol-3-yl)methyl]benzamide

CAS 391886-57-0C₁₇H₁₆N₄OS

N-[[4-(2,6-Diethylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3,4-dimethylbenzamide chemical structure, C22H26N4OS, CAS 391887-29-9

N-[[4-(2,6-Diethylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3,4-dimethylbenzamide

CAS 391887-29-9C₂₂H₂₆N₄OS

N-[[4-(4-Bromophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3,4,5-triethoxybenzamide chemical structure, C22H25BrN4O4S, CAS 391887-74-4

N-[[4-(4-Bromophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-3,4,5-triethoxybenzamide

CAS 391887-74-4C₂₂H₂₅BrN₄O₄S

3,4,5-Trimethoxy-N-[[4-(4-methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C20H22N4O5S, CAS 392247-72-2

3,4,5-Trimethoxy-N-[[4-(4-methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide

CAS 392247-72-2C₂₀H₂₂N₄O₅S

3-Methoxy-N-((4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C17H16N4O2S, CAS 391886-73-0

3-Methoxy-N-((4-phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide

CAS 391886-73-0C₁₇H₁₆N₄O₂S

N-[[4-(3-Methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-2-(trifluoromethyl)benzamide chemical structure, C18H15F3N4OS, CAS 391887-19-7

N-[[4-(3-Methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-2-(trifluoromethyl)benzamide

CAS 391887-19-7C₁₈H₁₅F₃N₄OS

2-Fluoro-N-((4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C16H12F2N4OS, CAS 391886-37-6

2-Fluoro-N-((4-(4-fluorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide

CAS 391886-37-6C₁₆H₁₂F₂N₄OS

N-[[4-(3-Chlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-2-(trifluoromethyl)benzamide chemical structure, C17H12ClF3N4OS, CAS 391887-14-2

N-[[4-(3-Chlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-2-(trifluoromethyl)benzamide

CAS 391887-14-2C₁₇H₁₂ClF₃N₄OS

N-[[4-(4-Bromophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-2,5-dichlorobenzamide chemical structure, C16H11BrCl2N4OS, CAS 391887-01-7

N-[[4-(4-Bromophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-2,5-dichlorobenzamide

CAS 391887-01-7C₁₆H₁₁BrCl₂N₄OS

2,5-Dichloro-N-[[4-(4-fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C16H11Cl2FN4OS, CAS 391887-02-8

2,5-Dichloro-N-[[4-(4-fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide

CAS 391887-02-8C₁₆H₁₁Cl₂FN₄OS

4-(tert-Butyl)-N-((4-(3,4-dichlorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C20H20Cl2N4OS, CAS 391886-67-2

4-(tert-Butyl)-N-((4-(3,4-dichlorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide

CAS 391886-67-2C₂₀H₂₀Cl₂N₄OS

3,4,5-Triethoxy-N-[[4-(4-fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C22H25FN4O4S, CAS 391887-75-5

3,4,5-Triethoxy-N-[[4-(4-fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide

CAS 391887-75-5C₂₂H₂₅FN₄O₄S

3-Fluoro-N-[[4-(3-methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C17H15FN4OS, CAS 391886-46-7

3-Fluoro-N-[[4-(3-methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide

CAS 391886-46-7C₁₇H₁₅FN₄OS

3,4,5-Trimethoxy-N-[[4-(3-methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C20H22N4O4S, CAS 391887-68-6

3,4,5-Trimethoxy-N-[[4-(3-methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide

CAS 391887-68-6C₂₀H₂₂N₄O₄S

3,4-Dimethoxy-N-[[4-(2-methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C19H20N4O4S, CAS 391887-57-3

3,4-Dimethoxy-N-[[4-(2-methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide

CAS 391887-57-3C₁₉H₂₀N₄O₄S

4-tert-Butyl-N-[[4-(4-fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C20H21FN4OS, CAS 391886-70-7

4-tert-Butyl-N-[[4-(4-fluorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide

CAS 391886-70-7C₂₀H₂₁FN₄OS

3,4,5-Triethoxy-N-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methyl]benzamide chemical structure, C22H26N4O4S, CAS 391887-70-0

3,4,5-Triethoxy-N-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methyl]benzamide

CAS 391887-70-0C₂₂H₂₆N₄O₄S

2,4-Dichloro-N-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methyl]benzamide chemical structure, C16H12Cl2N4OS, CAS 391886-89-8

2,4-Dichloro-N-[(4-phenyl-5-sulfanylidene-1H-1,2,4-triazol-3-yl)methyl]benzamide

CAS 391886-89-8C₁₆H₁₂Cl₂N₄OS

N-((4-(2-Methoxyphenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-4-nitrobenzamide chemical structure, C17H15N5O4S, CAS 391886-52-5

N-((4-(2-Methoxyphenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-4-nitrobenzamide

CAS 391886-52-5C₁₇H₁₅N₅O₄S

3-Methoxy-N-((5-thioxo-4-(3-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide chemical structure, C18H15F3N4O2S, CAS 391886-80-9

3-Methoxy-N-((5-thioxo-4-(3-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)benzamide

CAS 391886-80-9C₁₈H₁₅F₃N₄O₂S

N-((4-(3,4-Dichlorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3,4-dimethoxybenzamide chemical structure, C18H16Cl2N4O3S, CAS 391887-56-2

N-((4-(3,4-Dichlorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3,4-dimethoxybenzamide

CAS 391887-56-2C₁₈H₁₆Cl₂N₄O₃S

3,4,5-Trimethoxy-N-[[4-(2-methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C20H22N4O5S, CAS 391887-65-3

3,4,5-Trimethoxy-N-[[4-(2-methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide

CAS 391887-65-3C₂₀H₂₂N₄O₅S

N-((4-(3-Chlorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-fluorobenzamide chemical structure, C16H12ClFN4OS, CAS 391886-41-2

N-((4-(3-Chlorophenyl)-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-3-fluorobenzamide

CAS 391886-41-2C₁₆H₁₂ClFN₄OS

3-Methoxy-N-[[4-(2-methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide chemical structure, C18H18N4O3S, CAS 391886-76-3

3-Methoxy-N-[[4-(2-methoxyphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]benzamide

CAS 391886-76-3C₁₈H₁₈N₄O₃S