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Murcko scaffold

Ring system with 3 rings and 21 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
8
With full pages
3
Scaffold SMILES

O=C1CSC(=NN=Cc2ccccc2)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CSC(=NN=Cc2ccccc2)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

2-[[2-[2-[(4-Hydroxy-3-methoxyphenyl)methylidenehydrazinylidene]-3-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-5-yl]acetyl]amino]acetic acid chemical structure, C21H20N4O7S
2-[[2-[2-[(4-Hydroxy-3-methoxyphenyl)methylidenehydrazinylidene]-3-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-5-yl]acetyl]amino]acetic acid
C21H20N4O7S
2-((E)-2-((E)-(4-(Dimethylamino)benzylidene)hydrazono)-3-(4-hydroxyphenyl)-4-oxothiazolidin-5-yl)acetic acid chemical structure, C20H20N4O4S, CAS 314259-93-3
2-((E)-2-((E)-(4-(Dimethylamino)benzylidene)hydrazono)-3-(4-hydroxyphenyl)-4-oxothiazolidin-5-yl)acetic acid
CAS 314259-93-3C20H20N4O4S
[2-(Benzylidenehydrazono)-3-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-5-yl]acetic acid chemical structure, C18H15N3O4S
[2-(Benzylidenehydrazono)-3-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-5-yl]acetic acid
C18H15N3O4S
2-[(2E)-3-(4-Hydroxyphenyl)-2-[(E)-(4-nitrophenyl)methylidenehydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl]acetic acid chemical structure, C18H14N4O6S, CAS 425401-90-7
2-[(2E)-3-(4-Hydroxyphenyl)-2-[(E)-(4-nitrophenyl)methylidenehydrazinylidene]-4-oxo-1,3-thiazolidin-5-yl]acetic acid
CAS 425401-90-7C18H14N4O6S
2-((Z)-2-((Z)-Benzylidenehydrazono)-3-(4-hydroxyphenyl)-4-oxothiazolidin-5-yl)acetic acid chemical structure, C18H15N3O4S, CAS 303120-78-7
2-((Z)-2-((Z)-Benzylidenehydrazono)-3-(4-hydroxyphenyl)-4-oxothiazolidin-5-yl)acetic acid
CAS 303120-78-7C18H15N3O4S
(2Z)-2-[(E)-(4-Methoxyphenyl)methylidenehydrazinylidene]-3-phenyl-1,3-thiazolidin-4-one chemical structure, C17H15N3O2S, CAS 98052-60-9
(2Z)-2-[(E)-(4-Methoxyphenyl)methylidenehydrazinylidene]-3-phenyl-1,3-thiazolidin-4-one
CAS 98052-60-9C17H15N3O2S
2-[(2Z)-3-(4-Hydroxyphenyl)-4-oxo-2-[(Z)-2-(phenylmethylidene)hydrazin-1-ylidene]-1,3-thiazolidin-5-yl]acetic acid chemical structure, C18H15N3O4S
2-[(2Z)-3-(4-Hydroxyphenyl)-4-oxo-2-[(Z)-2-(phenylmethylidene)hydrazin-1-ylidene]-1,3-thiazolidin-5-yl]acetic acid
C18H15N3O4S
2-[[2-[2-[(E)-(4-Hydroxy-3-methoxyphenyl)methylidenehydrazinylidene]-3-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-5-yl]acetyl]amino]acetic acid chemical structure, C21H20N4O7S, CAS 7062-63-7
2-[[2-[2-[(E)-(4-Hydroxy-3-methoxyphenyl)methylidenehydrazinylidene]-3-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-5-yl]acetyl]amino]acetic acid
CAS 7062-63-7C21H20N4O7S