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Murcko scaffold

Ring system with 4 rings and 23 atoms

103 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
103
With full pages
21
Scaffold SMILES

O=C1c2ccccc2NC(c2ccccc2)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1c2ccccc2NC(c2ccccc2)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 103 chemicals

4(1H)-Quinazolinone, 2,3-dihydro-1-acetyl-2-(2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)- chemical structure, C25H24N2O5, CAS 136036-03-8
4(1H)-Quinazolinone, 2,3-dihydro-1-acetyl-2-(2,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-
CAS 136036-03-8C25H24N2O5
4(1H)-Quinazolinone, 2,3-dihydro-1-acetyl-3-(4-chlorophenyl)-2-(2,4-dimethoxyphenyl)- chemical structure, C24H21ClN2O4, CAS 136009-48-8
4(1H)-Quinazolinone, 2,3-dihydro-1-acetyl-3-(4-chlorophenyl)-2-(2,4-dimethoxyphenyl)-
CAS 136009-48-8C24H21ClN2O4
3-(4-Chlorophenyl)-2-phenyl-2,3-dihydroquinazolin-4(1H)-one chemical structure, C20H15ClN2O, CAS 63384-39-4
3-(4-Chlorophenyl)-2-phenyl-2,3-dihydroquinazolin-4(1H)-one
CAS 63384-39-4C20H15ClN2O
2-(2-Chlorophenyl)-3-[4-(dimethylamino)phenyl]-2,3-dihydroquinazolin-4(1H)-one chemical structure, C22H20ClN3O, CAS 370587-19-2
2-(2-Chlorophenyl)-3-[4-(dimethylamino)phenyl]-2,3-dihydroquinazolin-4(1H)-one
CAS 370587-19-2C22H20ClN3O
2-(3-Nitro-phenyl)-3-p-tolyl-2,3-dihydro-1H-quinazolin-4-one chemical structure, C21H17N3O3, CAS 5564-51-2
2-(3-Nitro-phenyl)-3-p-tolyl-2,3-dihydro-1H-quinazolin-4-one
CAS 5564-51-2C21H17N3O3
3-(4-Bromophenyl)-2-(3-nitrophenyl)-1,2-dihydroquinazolin-4-one chemical structure, C20H14BrN3O3, CAS 328090-75-1
3-(4-Bromophenyl)-2-(3-nitrophenyl)-1,2-dihydroquinazolin-4-one
CAS 328090-75-1C20H14BrN3O3
2,3-Bis(4-methylphenyl)-1,2-dihydroquinazolin-4-one chemical structure, C22H20N2O, CAS 331727-51-6
2,3-Bis(4-methylphenyl)-1,2-dihydroquinazolin-4-one
CAS 331727-51-6C22H20N2O
3-(4-Bromophenyl)-2-(4-methylphenyl)-1,2-dihydroquinazolin-4-one chemical structure, C21H17BrN2O, CAS 312632-31-8
3-(4-Bromophenyl)-2-(4-methylphenyl)-1,2-dihydroquinazolin-4-one
CAS 312632-31-8C21H17BrN2O
3-(4-Bromophenyl)-2-phenyl-2,3-dihydroquinazolin-4(1H)-one chemical structure, C20H15BrN2O, CAS 84770-65-0
3-(4-Bromophenyl)-2-phenyl-2,3-dihydroquinazolin-4(1H)-one
CAS 84770-65-0C20H15BrN2O
2,3-Bis(4-chlorophenyl)-1,2-dihydroquinazolin-4-one chemical structure, C20H14Cl2N2O, CAS 63384-42-9
2,3-Bis(4-chlorophenyl)-1,2-dihydroquinazolin-4-one
CAS 63384-42-9C20H14Cl2N2O
3-(4-Bromophenyl)-2-(4-chlorophenyl)-1,2-dihydroquinazolin-4-one chemical structure, C20H14BrClN2O, CAS 311330-07-1
3-(4-Bromophenyl)-2-(4-chlorophenyl)-1,2-dihydroquinazolin-4-one
CAS 311330-07-1C20H14BrClN2O
2,3-Bis(4-bromophenyl)-1,2-dihydroquinazolin-4-one chemical structure, C20H14Br2N2O, CAS 339321-04-9
2,3-Bis(4-bromophenyl)-1,2-dihydroquinazolin-4-one
CAS 339321-04-9C20H14Br2N2O
2-(4-Bromophenyl)-3-(4-ethoxyphenyl)-1,2-dihydroquinazolin-4-one chemical structure, C22H19BrN2O2, CAS 328090-73-9
2-(4-Bromophenyl)-3-(4-ethoxyphenyl)-1,2-dihydroquinazolin-4-one
CAS 328090-73-9C22H19BrN2O2
3-(4-Bromophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one chemical structure, C21H17BrN2O2, CAS 339321-03-8
3-(4-Bromophenyl)-2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one
CAS 339321-03-8C21H17BrN2O2
2-(4-Bromophenyl)-3-(4-chlorophenyl)-1,2-dihydroquinazolin-4-one chemical structure, C20H14BrClN2O, CAS 312632-34-1
2-(4-Bromophenyl)-3-(4-chlorophenyl)-1,2-dihydroquinazolin-4-one
CAS 312632-34-1C20H14BrClN2O
3-(4-Ethoxyphenyl)-2-(4-methylphenyl)-1,2-dihydroquinazolin-4-one chemical structure, C23H22N2O2, CAS 331727-50-5
3-(4-Ethoxyphenyl)-2-(4-methylphenyl)-1,2-dihydroquinazolin-4-one
CAS 331727-50-5C23H22N2O2
AG-205/36483053 chemical structure, C21H18N2O2, CAS 63384-41-8
AG-205/36483053
CAS 63384-41-8C21H18N2O2
2-(4-Bromophenyl)-3-(3,4-dichlorophenyl)-1,2-dihydroquinazolin-4-one chemical structure, C20H13BrCl2N2O, CAS 5618-49-5
2-(4-Bromophenyl)-3-(3,4-dichlorophenyl)-1,2-dihydroquinazolin-4-one
CAS 5618-49-5C20H13BrCl2N2O
3-(4-Ethylphenyl)-2-(4-methoxyphenyl)-1,2-dihydroquinazolin-4-one chemical structure, C23H22N2O2, CAS 311767-17-6
3-(4-Ethylphenyl)-2-(4-methoxyphenyl)-1,2-dihydroquinazolin-4-one
CAS 311767-17-6C23H22N2O2
3-(4-Fluorophenyl)-2-(3-nitrophenyl)-1,2-dihydroquinazolin-4-one chemical structure, C20H14FN3O3, CAS 328090-76-2
3-(4-Fluorophenyl)-2-(3-nitrophenyl)-1,2-dihydroquinazolin-4-one
CAS 328090-76-2C20H14FN3O3
2-(4-Ethoxyphenyl)-3-phenyl-1,2-dihydroquinazolin-4-one chemical structure, C22H20N2O2, CAS 359900-32-6
2-(4-Ethoxyphenyl)-3-phenyl-1,2-dihydroquinazolin-4-one
CAS 359900-32-6C22H20N2O2
2-(4-Fluorophenyl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one chemical structure, C20H15FN2O, CAS 359900-31-5
2-(4-Fluorophenyl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one
CAS 359900-31-5C20H15FN2O
3-(4-Ethoxyphenyl)-2-(3-nitrophenyl)-1,2-dihydroquinazolin-4-one chemical structure, C22H19N3O4, CAS 351889-43-5
3-(4-Ethoxyphenyl)-2-(3-nitrophenyl)-1,2-dihydroquinazolin-4-one
CAS 351889-43-5C22H19N3O4
2-(3-Hydroxyphenyl)-3-(4-methylphenyl)-1,2-dihydroquinazolin-4-one chemical structure, C21H18N2O2, CAS 361186-96-1
2-(3-Hydroxyphenyl)-3-(4-methylphenyl)-1,2-dihydroquinazolin-4-one
CAS 361186-96-1C21H18N2O2